Category: Research
Financial Behavior Might Help Diagnose Dementia Early
June 17, 2025
By analyzing a large UK dataset, scientists have identified various financial behaviors that might point to dementia years before it leads to loss of financial capacity [1]. The money trail
A New Method of Modifying Stem Cells
June 16, 2025
Researchers have investigated a never-before-used method of transfecting senescent mesenchymal stem cells (MSCs) and published their results In the Cell journal Molecular Therapy Nucleic Acids. Detergents for gene therapy Altering
A Popular Sweetener Adversely Affects Blood Vessels
June 13, 2025
A new study has lent more support to previous epidemiological data that ties the popular sugar substitute erythritol to elevated cardiovascular risk [1]. Deceptively sweet Sugar substitutes have been around
Preventing CRISPR From Causing Senescence
June 12, 2025
Researchers publishing in Cell Reports Medicine have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it. Breaking and
How Gut Microbiota Impact Endothelial Cell Senescence
June 11, 2025
In a recent study that included data from humans, mice, and cell culture experiments, researchers demonstrated that gut microbes and their metabolites can profoundly influence the senescence of endothelial cells.
New Study Could Pave the Way for Better Cancer Vaccines
June 10, 2025
Scientists have found that only about 1% of presented tumor antigens come from oncogenic mutations. The remaining 99%, previously overlooked, may offer better treatment targets [1]. Going after mutations Cancer
Younger Cohorts Show Less Dementia at the Same Age
June 6, 2025
While the overall prevalence of dementia might be rising due to population aging, a study has found that today’s older people seem to be less prone to dementia than in
New Insights Into How Neural Stem Cells Age
June 5, 2025
Researchers publishing in Aging Cell have used single-cell transcriptomics to discover new insights into how neural stem cells (NSCs) change with aging. Adults do generate neurons The adult brain does
Rejuve.AI: Just Another App or a Longevity Research Network?
June 5, 2025
On its website, Rejuve.AI, a company co-founded by its dynamic CEO, Jasmine Smith, and a renowned AI researcher, Ben Goertzel, promises a lot of things: to “democratize longevity, globally,” to
Educated ‘Night Owls’ Might Have More Cognitive Decline Risk
June 4, 2025
A recent analysis of over 20,000 middle-aged and older adults showed an association between a later chronotype (‘night owls’) and cognitive decline among highly educated people [1]. Early birds and
Blunting an Inflammatory Pathway Slows Alzheimer’s in Mice
June 3, 2025
Scientists have demonstrated that knocking out part of the cGAS-STING DNA-sensing pathway slows disease progression in a mouse model of Alzheimer’s, calming down microglia and protecting neurons [1]. STING operation
A Drug Combo Increases Lifespan in Mice by Over 30%
May 30, 2025
Combining rapamycin with the anti-cancer drug trametinib produced a synergistic effect and robust life extension in a new study [1]. A multi-node approach Rapamycin, which was first widely used as
How Plasma Exchange Affects Aging in a Human Trial
May 29, 2025
A placebo-controlled clinical trial, with results published in Aging Cell, has determined that plasma replacement has beneficial effects when combined with immunoglobulin, according to multiple epigenetic clocks and -omics biomarkers.
Why Some Mammals Live Much Longer Than Others
May 28, 2025
A recent study investigated differences in maximum lifespan potential among different mammalian species. The researchers found associations between gene family size expansion, maximum lifespan potential, and relative brain size. They
DNA Methylation Patterns Trace Blood Aging Dynamics
May 27, 2025
Scientists have created a new, highly effective method of tracing blood cells’ lineage. This can improve our understanding of clonal hematopoiesis and its impact on an aging organism [1]. Hostile
Financial Behavior Might Help Diagnose Dementia Early
June 17, 2025
By analyzing a large UK dataset, scientists have identified various financial behaviors that might point to dementia years before it leads to loss of financial capacity [1]. The money trail Alzheimer’s disease and related dementias remain a particularly hard nut for scientists to crack. One commonly
A New Method of Modifying Stem Cells
June 16, 2025
Researchers have investigated a never-before-used method of transfecting senescent mesenchymal stem cells (MSCs) and published their results In the Cell journal Molecular Therapy Nucleic Acids. Detergents for gene therapy Altering the genetics of a living person is much trickier than altering them in cells in a
A Popular Sweetener Adversely Affects Blood Vessels
June 13, 2025
A new study has lent more support to previous epidemiological data that ties the popular sugar substitute erythritol to elevated cardiovascular risk [1]. Deceptively sweet Sugar substitutes have been around for decades, and while some people have reported decreases in weight and blood glucose, a growing
Preventing CRISPR From Causing Senescence
June 12, 2025
Researchers publishing in Cell Reports Medicine have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it. Breaking and repairing DNA Genetic engineering of living cells through CRISPR/Cas9 technology requires three things to occur. The
How Gut Microbiota Impact Endothelial Cell Senescence
June 11, 2025
In a recent study that included data from humans, mice, and cell culture experiments, researchers demonstrated that gut microbes and their metabolites can profoundly influence the senescence of endothelial cells. They also explored the molecular processes underlying these changes [1]. Senescence in the blood vessels Endothelial
New Study Could Pave the Way for Better Cancer Vaccines
June 10, 2025
Scientists have found that only about 1% of presented tumor antigens come from oncogenic mutations. The remaining 99%, previously overlooked, may offer better treatment targets [1]. Going after mutations Cancer arises from a series of mutations that drive abnormal cellular behaviors, such as runaway proliferation. Cancerous
Younger Cohorts Show Less Dementia at the Same Age
June 6, 2025
While the overall prevalence of dementia might be rising due to population aging, a study has found that today’s older people seem to be less prone to dementia than in the past [1]. Are we having more dementia or less? While the robust rise in average
New Insights Into How Neural Stem Cells Age
June 5, 2025
Researchers publishing in Aging Cell have used single-cell transcriptomics to discover new insights into how neural stem cells (NSCs) change with aging. Adults do generate neurons The adult brain does generate new neurons [1], particularly in the hippocampus, the part of the brain responsible for memory
Rejuve.AI: Just Another App or a Longevity Research Network?
June 5, 2025
On its website, Rejuve.AI, a company co-founded by its dynamic CEO, Jasmine Smith, and a renowned AI researcher, Ben Goertzel, promises a lot of things: to “democratize longevity, globally,” to enable you to “take control of your data, and harness its earning potential,” and to “unite
Educated ‘Night Owls’ Might Have More Cognitive Decline Risk
June 4, 2025
A recent analysis of over 20,000 middle-aged and older adults showed an association between a later chronotype (‘night owls’) and cognitive decline among highly educated people [1]. Early birds and night owls One risk factor linked to dementia is a disrupted circadian rhythm, the natural 24-hour
Blunting an Inflammatory Pathway Slows Alzheimer’s in Mice
June 3, 2025
Scientists have demonstrated that knocking out part of the cGAS-STING DNA-sensing pathway slows disease progression in a mouse model of Alzheimer’s, calming down microglia and protecting neurons [1]. STING operation Inflammation is central to the pathogenesis of Alzheimer’s disease [2], which is accompanied by the accumulation
A Drug Combo Increases Lifespan in Mice by Over 30%
May 30, 2025
Combining rapamycin with the anti-cancer drug trametinib produced a synergistic effect and robust life extension in a new study [1]. A multi-node approach Rapamycin, which was first widely used as an immunosuppressant for transplant patients and is also used in oncology, is considered one of the
How Plasma Exchange Affects Aging in a Human Trial
May 29, 2025
A placebo-controlled clinical trial, with results published in Aging Cell, has determined that plasma replacement has beneficial effects when combined with immunoglobulin, according to multiple epigenetic clocks and -omics biomarkers. Looking for a signal Therapeutic plasma exchange (TPE), the practice of extracting and replacing a person’s
Why Some Mammals Live Much Longer Than Others
May 28, 2025
A recent study investigated differences in maximum lifespan potential among different mammalian species. The researchers found associations between gene family size expansion, maximum lifespan potential, and relative brain size. They also studied genomic features linked to lifespan evolution [1]. Maximum lifespan potential Maximum lifespan potential can
DNA Methylation Patterns Trace Blood Aging Dynamics
May 27, 2025
Scientists have created a new, highly effective method of tracing blood cells’ lineage. This can improve our understanding of clonal hematopoiesis and its impact on an aging organism [1]. Hostile takeover In the human body, a relatively small pool of hematopoietic stem cells (HSCs) sustains a