Category: Research
Senolytics Reduce Gut Inflammation in Mice
January 8, 2021
A few years ago, a team at Mayo Clinic led by Dr. James Kirkland treated mice with the cancer drug dasatinib and the popular dietary supplement quercetin, with results suggesting
Groundbreaking New Therapy for Progeria
January 7, 2021
A gene editing technique published in Nature has proven to be effective in a mouse model of Hutchinson–Gilford progeria syndrome (HGPS). A single error causes tremendous damage HGPS is a
A Cause of Genomic Instability Discovered
January 6, 2021
Research further illuminating the mechanisms of impaired DNA damage repair associated with aging has recently been published in the journal Aging. DNA damage repair is reduced as we age While
Fisetin May Be Useful in Treating Pulmonary Fibrosis
January 4, 2021
The results of a recent study suggest that fisetin appears to reduce the development of bleomycin-induced pulmonary fibrosis [1]. Fisetin is a plant polyphenol and part of the flavonoid group
Stem Cell Growth Factors Treat Alzheimer’s in Aged Mice
December 23, 2020
A new article published in Aging and Disease has taken a look at what two stem cell-activating growth factors can do in aged mice with Alzheimer’s-like pathology. Alzheimer’s disease (AD)
MYSM1 Prolongs Lifespan by Regulating DNA Repair
December 17, 2020
New research has shown that a DNA repair gene modulates lifespan in mice [1]. This may serve as a therapeutic avenue or at least open the way towards dissecting the
Decellularized, Functional Thymus Regeneration in Mice
December 16, 2020
Recent research published in Nature Communications has regenerated a functional thymus in mice, making several other discoveries along the way [1]. A new sub-type of thymus cell emerges Although it
New Discovery in How Stem Cells Protect Telomeres
December 15, 2020
Scientists have discovered a new telomere-protecting mechanism in embryonic stem cells. This discovery can bring us closer to solving the notorious problem of telomere attrition and to understanding the immortality
New Aging Clock May Be Most Accurate to Date
December 14, 2020
These days, it seems like you cannot go for a walk without tripping over another aging clock, and today is no exception. DeepMAge, a DNA methylation aging clock developed using
Gene Therapy Trial Successfully Improves Vision
December 11, 2020
A team of researchers, including Dr. Patrick Yu-Wai-Man from the University of Cambridge and Dr. José-Alain Sahel from the University of Pittsburgh and Institut de la Vision, Paris, has successfully
Aging Brain Function Partially Restored With Small Molecule
December 10, 2020
Researchers from the University of California, San Francisco have discovered that a small molecule partially restores the cognitive abilities of mice suffering from age-related memory decline [1]. A response to
Kidney Progenitor Cells Derived from Urine
December 9, 2020
Recent data published in Scientific Reports has characterized human urine-derived renal stem cells, a potential non-invasive source for kidney tissue engineering and regenerative medicine. An unlikely source for kidney cells
Reviewing CD38, a Regulator of NAD+
December 8, 2020
We recently explored why NAD+ declines during aging, and today, we want to spotlight a new review that takes a deep dive into CD38, one of the reasons for this
AI Cracks the Protein Folding Problem
December 8, 2020
Alphabet’s subsidiary DeepMind has all but solved the problem of predicting a protein’s shape from its amino acid sequence. DeepMind’s program AlphaFold reached close to 90% average accuracy, which is
Study Links Glucosamine and Chondroitin to Reduced Mortality
December 7, 2020
Glucosamine and chondroitin are commonly bundled together as a dietary supplement, and a new study suggests that taking them may significantly reduce mortality. This builds on a previous epidemiological study
Senolytics Reduce Gut Inflammation in Mice
January 8, 2021
A few years ago, a team at Mayo Clinic led by Dr. James Kirkland treated mice with the cancer drug dasatinib and the popular dietary supplement quercetin, with results suggesting that the combination was able to destroy senescent cells. This combination was part of the first
Groundbreaking New Therapy for Progeria
January 7, 2021
A gene editing technique published in Nature has proven to be effective in a mouse model of Hutchinson–Gilford progeria syndrome (HGPS). A single error causes tremendous damage HGPS is a well-known disease that causes visible aging and early death in children. In progeria, the lamina that
A Cause of Genomic Instability Discovered
January 6, 2021
Research further illuminating the mechanisms of impaired DNA damage repair associated with aging has recently been published in the journal Aging. DNA damage repair is reduced as we age While we have multiple mechanisms for repairing genomic damage, one type of damage, double-strand breaks, is particularly
Fisetin May Be Useful in Treating Pulmonary Fibrosis
January 4, 2021
The results of a recent study suggest that fisetin appears to reduce the development of bleomycin-induced pulmonary fibrosis [1]. Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the
Stem Cell Growth Factors Treat Alzheimer’s in Aged Mice
December 23, 2020
A new article published in Aging and Disease has taken a look at what two stem cell-activating growth factors can do in aged mice with Alzheimer’s-like pathology. Alzheimer’s disease (AD) is perhaps the most age-related of all age-related diseases. Perhaps not coincidentally, it has also been
MYSM1 Prolongs Lifespan by Regulating DNA Repair
December 17, 2020
New research has shown that a DNA repair gene modulates lifespan in mice [1]. This may serve as a therapeutic avenue or at least open the way towards dissecting the links between DNA damage and senescence. MYSM1 is a gene that removes a molecular mark known
Decellularized, Functional Thymus Regeneration in Mice
December 16, 2020
Recent research published in Nature Communications has regenerated a functional thymus in mice, making several other discoveries along the way [1]. A new sub-type of thymus cell emerges Although it is imperative to our immune health, the thymus is an under-studied organ that slowly disappears as
New Discovery in How Stem Cells Protect Telomeres
December 15, 2020
Scientists have discovered a new telomere-protecting mechanism in embryonic stem cells. This discovery can bring us closer to solving the notorious problem of telomere attrition and to understanding the immortality of cancer cells [1]. Keeping telomeres in the loop One function of telomeres is to prevent
New Aging Clock May Be Most Accurate to Date
December 14, 2020
These days, it seems like you cannot go for a walk without tripping over another aging clock, and today is no exception. DeepMAge, a DNA methylation aging clock developed using deep learning, has recently been created by the Hong Kong-based company Deep Longevity. There are two
Gene Therapy Trial Successfully Improves Vision
December 11, 2020
A team of researchers, including Dr. Patrick Yu-Wai-Man from the University of Cambridge and Dr. José-Alain Sahel from the University of Pittsburgh and Institut de la Vision, Paris, has successfully treated 37 participants suffering from Leber hereditary optic neuropathy (LHON). A landmark trial for mitochondrial gene
Aging Brain Function Partially Restored With Small Molecule
December 10, 2020
Researchers from the University of California, San Francisco have discovered that a small molecule partially restores the cognitive abilities of mice suffering from age-related memory decline [1]. A response to damage As the researchers explain, when neurons detect that something has gone wrong, either through the
Kidney Progenitor Cells Derived from Urine
December 9, 2020
Recent data published in Scientific Reports has characterized human urine-derived renal stem cells, a potential non-invasive source for kidney tissue engineering and regenerative medicine. An unlikely source for kidney cells The kidney is, by far, the most frequently transplanted organ. This is because donors are much
Reviewing CD38, a Regulator of NAD+
December 8, 2020
We recently explored why NAD+ declines during aging, and today, we want to spotlight a new review that takes a deep dive into CD38, one of the reasons for this decline [1]. The review focuses on one of the primary culprits of NAD+ decline, the enzyme
AI Cracks the Protein Folding Problem
December 8, 2020
Alphabet’s subsidiary DeepMind has all but solved the problem of predicting a protein’s shape from its amino acid sequence. DeepMind’s program AlphaFold reached close to 90% average accuracy, which is comparable to experimental structural analysis. Proteins: life’s multitool Proteins are the primary tool with which organisms
Study Links Glucosamine and Chondroitin to Reduced Mortality
December 7, 2020
Glucosamine and chondroitin are commonly bundled together as a dietary supplement, and a new study suggests that taking them may significantly reduce mortality. This builds on a previous epidemiological study from earlier this year, which showed that glucosamine supplementation correlates with reduced all-cause mortality. What are