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September 09, 2026
In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody wants to wait that long. Therefore, it is essential...
August 26, 2026
A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. long and moderate Exercise is a well-known lifestyle factor that can positively impact health. Exercise benefits multiple cells,...
August 12, 2026
A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer treatments more effective [1]. The aging immune system Aging has a profound impact on the immune system. It leads to a progressive decline in immune...
July 22, 2026
A recent review discusses the development of biological aging clocks, their capabilities and limitations, the discoveries they enabled, and possible future developments in this area [1]. How do we measure aging? Developments in science and technology have allowed researchers to move beyond speculation and philosophical debates about aging to study its molecular underpinnings and the...
July 08, 2026
In a recently published perspective paper, the author argues that the UK's official health guidelines on physical activity and protein intake should be revised to recommend levels necessary to achieve optimal health, rather than the bare minimum currently recommended [1]. From bare minimum to optimizing for healthspan Current government guidelines on nutrition and physical activity...
June 24, 2026
A recent study suggests that hyperglycosylation in brain tissue can be a hallmark of Alzheimer’s disease [1]. Lesser-known Alzheimer’s molecular features Pathological deposits of amyloid-β plaques and tau tangles in the brain are probably the most well-known features of Alzheimer’s disease. However, Alzheimer’s also involves various metabolism-related pathologies, such as alterations in glucose metabolism [2],...