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June 24, 2026
A recent study suggests that hyperglycosylation in brain tissue can be a hallmark of Alzheimer’s disease [1]. Lesser-known Alzheimer’s molecular features Pathological deposits of amyloid-β plaques and tau tangles in the brain are probably the most well-known features of Alzheimer’s disease. However, Alzheimer’s also involves various metabolism-related pathologies, such as alterations in glucose metabolism [2],...
June 10, 2026
In a recent paper, researchers have proposed that the immune system and immune surveillance play a central role in maintaining microbial composition throughout life by suppressing microbial proliferation and that aging weakens these processes [1]. Lifelong companions Aging leads to the deterioration of the organs and systems in the human body, while also altering the...
May 27, 2026
A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared with premenopausal women, after adjusting for age [1]. Menopausal health decline The menopausal transition, and the associated changes in hormonal levels, especially declining estrogen levels, mark not only the...
May 13, 2026
This month, a group of researchers published an annual report on the clinical trials that are testing drugs for Alzheimer’s disease. Overall, they reported an increase in the number of trials, with 158 drugs investigated across 192 trials [1]. A growing problem The projections regarding the prevalence of Alzheimer’s disease are merciless. While in 2017,...
April 29, 2026
A recent study found an association between longer and more frequent daytime napping and higher mortality risk. The authors suggest using napping frequency and duration as behavioral markers of increased mortality risk [1]. Common activity with a dark side Daytime napping is a relatively common activity among older adults. It is estimated that between 20%...
April 22, 2026
An investigation into the aging immune system identified age-related changes, including sex-dependent differences, in immune cell subpopulations and gene expression. In general, females showed greater age-related changes than males, including greater changes in autoimmune gene expression [1]. Cell-by-cell analysis Aging results in changes to the function and composition of immune cells, collectively referred to as...