Tag: Biomarkers

Researchers have created a deep learning-based biomarker, SASP Score, that evaluates the combined effects of the senescence-associated secretory phenotype (SASP) circulating in the bloodstream. Measuring an overall burden Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody wants to wait that long. Therefore, it is essential...

Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and bands – and two rings. He is convinced that these small but powerful gadgets will help drive the transition from today’s “sickcare” to true healthcare,...

A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to...

A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how patients respond to treatments. The authors reported that using biomarkers enabled them to gain insights into the molecular processes that contribute to improved cognition following human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF, sargramostim)...

In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature of aging has been a problem since people first endeavored to live longer, to the point that finding the right questions can matter more than...