Tag: Liver

A recent study identified SRSF1, an RNA-processing and splicing factor, as a molecule with geroprotective potential. Inducing SRSF1 expression rejuvenated human cells in vitro, extended lifespan, and significantly reduced frailty in mice [1]. Alternative approaches Differentiated cells have the capacity to rejuvenate if an appropriate molecular environment is provided. The best-known factors that enable cellular...

Researchers have described a method of using exosomes derived from mesenchymal stem cells (MSCs) to fight harmful metabolic changes in the liver. Another look at exosomes This is far from the first attempt at using MSC-derived exosomes, particularly exosomes derived from MSCs originally taken from human umbilical cord tissue (HucMDEs derived from HucMSCs), to treat...

Scientists have discovered that obesity causes macrophages to ramp up mitochondrial DNA production, leading to more inflammation [1]. Obesity and inflammation Obesity is associated with multiple acute and chronic conditions, including cardiovascular disease and various metabolic disorders [2]. Increased sterile (not pathogen-induced) chronic inflammation is a major mechanism behind this wide impact [3]. A new...

A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Bringing back the Ts Immunosenescence, the gradual deterioration of the immune system, is a central aspect of aging. Research has tied it to increased cancer incidence,...

An analysis of UK Biobank data showed an association between regular glucosamine use and significantly lower risks of seven non-communicable chronic diseases [1]. A common supplement Glucosamine, a sugar molecule with an amine group (amino sugar), is a supplement used by almost 20% of middle-aged adults in the U.S., U.K., and Australia [2]. It is...

In Aging Cell, researchers have found that exposing ordinary Black 6 mice to a more natural environment accelerates rather than slows the aging of their livers. When natural doesn't mean better It is a well-known fact that laboratory animals live in controlled conditions beyond that of wild animals or even most pets. Temperature and food...