Tag: Metabolism

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. long and moderate Exercise is a well-known lifestyle factor that can positively impact health. Exercise benefits multiple cells,...

Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too much of a regulator leads to dysregulation Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles...

A new study suggests that regular planned exercise, not just being generally active, protects against certain aspects of muscle aging [1]. Are trained muscles younger? With age, skeletal muscles lose strength, metabolic flexibility, and mitochondrial capacity. While regular exercise slows many aspects of functional aging [2], just how deeply training affects the molecular state of...

In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it...

Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing the loss of function This paper begins by highlighting a core problem of using self-derived (autologous) stem cells for treatments in older people: the cells...

In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous fat. While this kind of fat is obviously not healthy to have in large amounts, it is not as immediately dangerous...