Category: News
Blocking STING Helps Preserve Bone in Aging Mice
October 16, 2026
A new study links STING-mediated signals from marrow fat cells to inflammation and declining NAD⁺ levels in bone-forming cells. Interrupting this pathway helped preserve aging bone [1]. Making old bones
Making SIRT1 and NAD+ Therapies Work in People
October 15, 2026
Reviewers publishing in Biology have elucidated SIRT1 functional reserve as an aspect of aging, describing how its depletion is an upstream cause of age-related disorders at the cellular level and
Menopausal Serum Protein Changes May Predict Brain Health
October 14, 2026
A recent analysis of serum protein changes identified 16 proteins related to inflammatory, synaptic, metabolic, and Alzheimer’s disease processes whose levels change during the menopausal transition [1]. These changes were
Low-Fat Vegan Diet Shows Benefits in Type 2 Diabetes
October 13, 2026
A human trial found that even without caloric restriction, a low-fat, plant-based diet improved blood sugar control, reduced liver fat, and lowered the quantity of advanced glycation end products (AGEs)
An Anti-Senescence Gene May Fight Spinal Disc Deterioration
October 12, 2026
In Aging Cell, a team of researchers has described how a little-known gene, ZNF865, has a significant influence on back pain through the regulation of cellular senescence. Lower back pain
Gut Bacteria Molecule Slows Atherosclerosis in Mice
October 9, 2026
A new study highlights a fatty acid produced by a particular genus of bacteria as a “natural statin,” suggesting a new way of treating atherosclerosis [1]. Bacteria and cholesterol Atherosclerosis
Untangling Differences in Senescent Cellular Signaling
October 8, 2026
In Aging, researchers have described the differences between the secretions of cells driven senescent through a cancer gene and cells that stopped proliferating due to p16 expression. A difference of
Declining Autophagy Impairs Senescent Cell Clearance
October 6, 2026
A new study links an age-related decline in cellular maintenance to impaired immune clearance. Activating the pathway reduced signs of senescence in aged mice [1]. Senescence and autophagy Cellular senescence,
The Biomarkers That Predict Mortality Risk
October 5, 2026
Researchers have discovered key biomarkers that are strongly linked to all-cause mortality and identified four measurements with independent predictive power. Biological versus chronological This paper opens with a discussion of
FDA Leaders Name Longevity a Priority at ARDD
October 2, 2026
At a panel in Boston, senior officials announced plans to include aging in the agency’s regulatory science agenda and discussed how therapies could move toward approval. Longevity has a partner
Rejuvenation Roundup September 2026
October 1, 2026
Which generation will be considered “the last to die” of age-related diseases is ultimately a question of technological development and deployment. Here’s what’s been done on that front in September.
Transplanted Hearts Shift Toward Recipients’ Molecular Age
September 29, 2026
A new preprint study suggests that transplanted hearts’ epigenetic age and possibly function are influenced by their recipients’ age. The findings can be relevant to both expanding the donor pool
A New Metric for Overall Senescent Cell Burden
September 28, 2026
Researchers have created a deep learning-based biomarker, SASP Score, that evaluates the combined effects of the senescence-associated secretory phenotype (SASP) circulating in the bloodstream. Measuring an overall burden Gathering the
Creatine Protects Lean Mass Even Without Exercise
September 25, 2026
According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise. It also enhanced the effects of a combined diet and exercise
Giving Cells Fresh Mitochondria Helps Clear Damaged Ones
September 24, 2026
Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart’s ability to process energy. Mitochondrial transplantation was found to be effective against this increase
Blocking STING Helps Preserve Bone in Aging Mice
October 16, 2026
A new study links STING-mediated signals from marrow fat cells to inflammation and declining NAD⁺ levels in bone-forming cells. Interrupting this pathway helped preserve aging bone [1]. Making old bones Our bones live a complex life, as they are constantly remodeled: cells called osteoclasts break down
Making SIRT1 and NAD+ Therapies Work in People
October 15, 2026
Reviewers publishing in Biology have elucidated SIRT1 functional reserve as an aspect of aging, describing how its depletion is an upstream cause of age-related disorders at the cellular level and explaining why many prospective therapies that increase SIRT1 and NAD+ have not had promising results. Managing
Menopausal Serum Protein Changes May Predict Brain Health
October 14, 2026
A recent analysis of serum protein changes identified 16 proteins related to inflammatory, synaptic, metabolic, and Alzheimer’s disease processes whose levels change during the menopausal transition [1]. These changes were linked to cognitive health later in life. The time for interventions Menopause is mostly known as
Low-Fat Vegan Diet Shows Benefits in Type 2 Diabetes
October 13, 2026
A human trial found that even without caloric restriction, a low-fat, plant-based diet improved blood sugar control, reduced liver fat, and lowered the quantity of advanced glycation end products (AGEs) in the skin [1]. An all-you-can-eat vegan buffet Type 2 diabetes is an age-related metabolic disorder
An Anti-Senescence Gene May Fight Spinal Disc Deterioration
October 12, 2026
In Aging Cell, a team of researchers has described how a little-known gene, ZNF865, has a significant influence on back pain through the regulation of cellular senescence. Lower back pain and senescence are related The link between cellular senescence and back pain has been thoroughly documented,
Gut Bacteria Molecule Slows Atherosclerosis in Mice
October 9, 2026
A new study highlights a fatty acid produced by a particular genus of bacteria as a “natural statin,” suggesting a new way of treating atherosclerosis [1]. Bacteria and cholesterol Atherosclerosis develops when cholesterol-rich particles accumulate in arterial walls, driving inflammation and plaque buildup. The liver helps
Untangling Differences in Senescent Cellular Signaling
October 8, 2026
In Aging, researchers have described the differences between the secretions of cells driven senescent through a cancer gene and cells that stopped proliferating due to p16 expression. A difference of kind The SASP is a mix of many components that have various effects on the cells
Declining Autophagy Impairs Senescent Cell Clearance
October 6, 2026
A new study links an age-related decline in cellular maintenance to impaired immune clearance. Activating the pathway reduced signs of senescence in aged mice [1]. Senescence and autophagy Cellular senescence, which occurs when cells stop dividing and start emitting largely pro-inflammatory stress signals, the senescence-associated secretory
The Biomarkers That Predict Mortality Risk
October 5, 2026
Researchers have discovered key biomarkers that are strongly linked to all-cause mortality and identified four measurements with independent predictive power. Biological versus chronological This paper opens with a discussion of a familiar fact for people interested in living longer: one’s biological age is not the same
FDA Leaders Name Longevity a Priority at ARDD
October 2, 2026
At a panel in Boston, senior officials announced plans to include aging in the agency’s regulatory science agenda and discussed how therapies could move toward approval. Longevity has a partner The 2026 edition of the Aging Research and Drug Discovery Meeting (ARDD) kicked off yesterday. This
Rejuvenation Roundup September 2026
October 1, 2026
Which generation will be considered “the last to die” of age-related diseases is ultimately a question of technological development and deployment. Here’s what’s been done on that front in September. Interviews The Last Generation to Die: Interview With Tim Maupin: Filmmaker Tim Maupin has spent a
Transplanted Hearts Shift Toward Recipients’ Molecular Age
September 29, 2026
A new preprint study suggests that transplanted hearts’ epigenetic age and possibly function are influenced by their recipients’ age. The findings can be relevant to both expanding the donor pool and rejuvenation through organ replacement [1]. The heart of the matter Over the last few decades,
A New Metric for Overall Senescent Cell Burden
September 28, 2026
Researchers have created a deep learning-based biomarker, SASP Score, that evaluates the combined effects of the senescence-associated secretory phenotype (SASP) circulating in the bloodstream. Measuring an overall burden Gathering the data needed to evaluate a person’s circulating SASP is as simple as taking a blood draw.
Creatine Protects Lean Mass Even Without Exercise
September 25, 2026
According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise. It also enhanced the effects of a combined diet and exercise intervention [1]. How to lose weight but not muscle As people age, they often accumulate fat
Giving Cells Fresh Mitochondria Helps Clear Damaged Ones
September 24, 2026
Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart’s ability to process energy. Mitochondrial transplantation was found to be effective against this increase in a mouse model. The heart needs energy Mitophagy, the process of eliminating damaged mitochondria, is