Category: News
HDAC Inhibitors Linked to Cellular Senescence
July 19, 2021
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, can lead to cellular senescence. What is a histone,
PulseChain Airdrop Raises $20m for SENS
July 17, 2021
The SENS Research Foundation has apparently already raised four times its annual income thanks to the PulseChain Airdrop. The PulseChain airdrop supporting aging research Richard Heart, the founder of HEX,
Loss of Peptide Not Amyloid Plaques a New Alzheimer’s Target
July 16, 2021
A recent study, led by the University of Cincinnati in collaboration with the Karolinska Institute in Sweden, challenges the popular amyloid hypothesis that has dominated Alzheimer’s research for decades. Amyloid
Engineering Cells to Avoid Immune Detection in Transplants
July 15, 2021
Gene editing can make stem cells invisible to the immune system, making it possible to carry out cell therapy transplants without suppressing the patients’ immune response [1]. Help me help
The Enormous Economic Benefits of Targeting Aging
July 14, 2021
Using Peter Pan, Wolverine, and a powerful economic model, a trio of prominent scientists argues that slowing aging can bring gargantuan economic benefits – an order of magnitude bigger than
NMN Enhances Aerobic Capacity in Amateur Runners
July 14, 2021
A clinical trial of endurance runners recently published in the Journal of the International Society of Sports Nutrition found nicotinamide mononucleotide (NMN) to increase several measures of aerobic capacity. Could
Telomere Loss And The Development Of Fibrosis
July 13, 2021
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts,
Senolytics Improve Spinal Cord Recovery in Mice
July 12, 2021
A new study published in Cell Reports has shown that the senolytic navitoclax (ABT-263) helps mice heal from spinal cord injuries [1]. The difference between mice and zebrafish The zebrafish
Senolytics Show Positive Results in Phase 1 Clinical Trial
July 9, 2021
Leading the pack is never easy, but today, UNITY Biotechnology is back with some positive news for senolytics. Being first is not always easy UNITY Biotechnology is a company that
Castration Lengthens Lifespan of Sheep by Altering Androgens
July 8, 2021
Researchers have shown that castration makes male sheep live longer, and they’ve also used genomic data to get a basic understanding of the mechanism behind this longevity [1]. While castration
Niacin Tested Against Parkinson’s Disease
July 7, 2021
A clinical trial on the effectiveness of niacin supplementation in Parkinson’s disease patients has recently been published in Frontiers in Aging Neuroscience. The link between niacin and Parkinson’s disease Niacin
What is Niacin? A Summary of Nicotinic Acid
July 7, 2021
Niacin is a common dietary supplement with a long research history and more than a few tricks up its sleeve. Recent human trials have shed new light on its possible
Testosterone Restores Brain Function in Old Male Rats
July 6, 2021
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Previous research has shown that testosterone supplementation
Ginseng Compound Reduces Senescent Marker in Humans
July 5, 2021
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours
Caloric Restriction Attenuates Immunosenescence
July 2, 2021
Scientists have shown in mice that long-term caloric restriction can attenuate age-related immunosenescence on par with antibody-mediated clearance of senescent T-cells. On top of that, caloric restriction predictably improved glucose
HDAC Inhibitors Linked to Cellular Senescence
July 19, 2021
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, can lead to cellular senescence. What is a histone, anyway? In biology, a histone is a protein that binds to DNA in order to control
PulseChain Airdrop Raises $20m for SENS
July 17, 2021
The SENS Research Foundation has apparently already raised four times its annual income thanks to the PulseChain Airdrop. The PulseChain airdrop supporting aging research Richard Heart, the founder of HEX, is about to launch a new cryptocurrency called PulseChain. As part of that launch, he has
Loss of Peptide Not Amyloid Plaques a New Alzheimer’s Target
July 16, 2021
A recent study, led by the University of Cincinnati in collaboration with the Karolinska Institute in Sweden, challenges the popular amyloid hypothesis that has dominated Alzheimer’s research for decades. Amyloid accumulation may be the consequence, not the cause Over 100 years ago, Alois Alzheimer originally identified
Engineering Cells to Avoid Immune Detection in Transplants
July 15, 2021
Gene editing can make stem cells invisible to the immune system, making it possible to carry out cell therapy transplants without suppressing the patients’ immune response [1]. Help me help you Cellular therapies involve transplanting cells into a patient to replace the activity of malfunctioning or
The Enormous Economic Benefits of Targeting Aging
July 14, 2021
Using Peter Pan, Wolverine, and a powerful economic model, a trio of prominent scientists argues that slowing aging can bring gargantuan economic benefits – an order of magnitude bigger than previously thought [1]. The marriage of economics and geroscience The paper, published in Nature Aging, looks
NMN Enhances Aerobic Capacity in Amateur Runners
July 14, 2021
A clinical trial of endurance runners recently published in the Journal of the International Society of Sports Nutrition found nicotinamide mononucleotide (NMN) to increase several measures of aerobic capacity. Could NMN and exercise be synergistic? NMN is a NAD+ precursor well known to longevity researchers for
Telomere Loss And The Development Of Fibrosis
July 13, 2021
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts, cells that are a part of organ fibrosis. It also documents the link between telomere attrition
Senolytics Improve Spinal Cord Recovery in Mice
July 12, 2021
A new study published in Cell Reports has shown that the senolytic navitoclax (ABT-263) helps mice heal from spinal cord injuries [1]. The difference between mice and zebrafish The zebrafish is a well-known species studied for its regenerative abilities, so the researchers began their investigation by
Senolytics Show Positive Results in Phase 1 Clinical Trial
July 9, 2021
Leading the pack is never easy, but today, UNITY Biotechnology is back with some positive news for senolytics. Being first is not always easy UNITY Biotechnology is a company that has been developing senolytics for the removal of senescent cells, which accumulate with age, drive chronic
Castration Lengthens Lifespan of Sheep by Altering Androgens
July 8, 2021
Researchers have shown that castration makes male sheep live longer, and they’ve also used genomic data to get a basic understanding of the mechanism behind this longevity [1]. While castration is unlikely to be part of a life extension therapy, unraveling its effect on lifespan will
Niacin Tested Against Parkinson’s Disease
July 7, 2021
A clinical trial on the effectiveness of niacin supplementation in Parkinson’s disease patients has recently been published in Frontiers in Aging Neuroscience. The link between niacin and Parkinson’s disease Niacin is a form of vitamin B3 that is commonly manufactured as a dietary supplement. Patients with
What is Niacin? A Summary of Nicotinic Acid
July 7, 2021
Niacin is a common dietary supplement with a long research history and more than a few tricks up its sleeve. Recent human trials have shed new light on its possible role in addressing mitochondrial dysfunction and aging. What is niacin? Niacin is a form of water-soluble
Testosterone Restores Brain Function in Old Male Rats
July 6, 2021
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Previous research has shown that testosterone supplementation helps offset some of the symptoms of Alzheimer’s disease [1] and Parkinson’s disease [2] in men.
Ginseng Compound Reduces Senescent Marker in Humans
July 5, 2021
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours after exercise. An experiment to link p16INK4a, aging, exercise, and Rg1 The cell cycle inhibitor p16INK4a,
Caloric Restriction Attenuates Immunosenescence
July 2, 2021
Scientists have shown in mice that long-term caloric restriction can attenuate age-related immunosenescence on par with antibody-mediated clearance of senescent T-cells. On top of that, caloric restriction predictably improved glucose tolerance and lowered inflammation [1]. Senescent cells: inflamed and half-dead Immunosenescence is an umbrella term for