Category: News
Life Extension – Humanity or Individuals First?
June 5, 2021
What is it that really matters: preserving individual lives or preserving humanity? Is it more important to grant individuals the option to live as long as they’d like in good
Dr. Zalzala: PEARL Trial Could Advance the Longevity Field
June 3, 2021
We are very excited to be crowdfunding PEARL, one of the few human trials of rapamycin, which is probably the most promising anti-aging molecule known today. Dysregulation of nutrient sensing
Transcriptomic Aging Clock Measures More Than Just Age
June 3, 2021
Researchers have developed a new transcriptomic aging clock that incorporates information about biological pathways. With this approach, the clock predicts not only age but also how the state of various
Removing and Replacing Mitochondria in Human Cells
June 2, 2021
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering
Twin Study Shows That Diet and Exercise Lower Biological Age
June 1, 2021
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors – smoking, drinking, physical activity, and diet – affect biological age according to two biological age
Rejuvenation Roundup May 2021
June 1, 2021
Another month passes, and more progress is made! As we kick off the beginning of summer, we have plenty of news to report regarding our upcoming conference and current campaign
Heavy Alcohol Use Linked to Greater Epigenetic Age in Women
May 31, 2021
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. A
What is alpha-ketoglutarate? A Summary of AKG
May 31, 2021
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due
Resilience as a New Measure of Biological Age
May 28, 2021
In a new paper published in Nature, a group of scientists led by Peter Fedichev explores human longevity through the concept of loss of resilience, by which the researchers mean
Ask the PEARL Team Anything!
May 28, 2021
Today, we want to announce we are doing an AMA on Reddit Futurology! The Ask Me Anything thread will be open May 28 and 29 for pre-questions, and on May
Long Non-Coding RNAs as an Alternative to Senolytics
May 27, 2021
New research has identified a set of long noncoding RNAs involved in inflammaging and the senescence-associated secretory phenotype (SASP) [1]. These RNAs are conserved across a range of species, including
Oisín Announces $5 Million in New Seed Funding
May 27, 2021
Today, Oisín Biotechnologies, a well-known developer of senolytics, drugs that destroy harmful senescent cells, has announced that it has more than doubled its total funding through an oversubscribed round. This
Cytosolic dsDNA as a Marker of Senescence
May 26, 2021
Senescent cells are surprisingly hard to identify, but a recent publication in Tissue and Cell makes the case for using cytoplasmic DNA as a marker of senescence. What makes a
Overwork Linked to Heart Disease and Stroke
May 25, 2021
In the largest study of its kind to date, researchers have revealed that a considerable part of all deaths from ischemic heart disease and stroke worldwide is caused by working
OSKM in Early Life Increases Lifespan in Mice
May 24, 2021
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. A single reset versus lifetime resetting The team chose a
Life Extension – Humanity or Individuals First?
June 5, 2021
What is it that really matters: preserving individual lives or preserving humanity? Is it more important to grant individuals the option to live as long as they’d like in good health, or is it more important to ensure the preservation of our species? This sort of
Dr. Zalzala: PEARL Trial Could Advance the Longevity Field
June 3, 2021
We are very excited to be crowdfunding PEARL, one of the few human trials of rapamycin, which is probably the most promising anti-aging molecule known today. Dysregulation of nutrient sensing (the ability of cells to adjust their metabolism to the amount of nutrients available) is thought
Transcriptomic Aging Clock Measures More Than Just Age
June 3, 2021
Researchers have developed a new transcriptomic aging clock that incorporates information about biological pathways. With this approach, the clock predicts not only age but also how the state of various genetic pathways changes with age, providing insight into the transcriptional changes involved in aging. Time for
Removing and Replacing Mitochondria in Human Cells
June 2, 2021
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Out with the old, in with the
Twin Study Shows That Diet and Exercise Lower Biological Age
June 1, 2021
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors – smoking, drinking, physical activity, and diet – affect biological age according to two biological age clocks. Their findings were a mixed bag, but they found evidence for eating lots of fruits
Rejuvenation Roundup May 2021
June 1, 2021
Another month passes, and more progress is made! As we kick off the beginning of summer, we have plenty of news to report regarding our upcoming conference and current campaign along with business news and the latest in rejuvenation research. LEAF News Summer is approaching, and
Heavy Alcohol Use Linked to Greater Epigenetic Age in Women
May 31, 2021
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. A large study with a few conclusive results This study, the first of its kind to show
What is alpha-ketoglutarate? A Summary of AKG
May 31, 2021
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. What is alpha-ketoglutarate? AKG is a naturally occurring endogenous intermediary
Resilience as a New Measure of Biological Age
May 28, 2021
In a new paper published in Nature, a group of scientists led by Peter Fedichev explores human longevity through the concept of loss of resilience, by which the researchers mean the gradual age-related expansion of time that the body needs to recover from stress, such as
Ask the PEARL Team Anything!
May 28, 2021
Today, we want to announce we are doing an AMA on Reddit Futurology! The Ask Me Anything thread will be open May 28 and 29 for pre-questions, and on May 30 and 31, the PEARL team will be answering questions. This is your opportunity to ask
Long Non-Coding RNAs as an Alternative to Senolytics
May 27, 2021
New research has identified a set of long noncoding RNAs involved in inflammaging and the senescence-associated secretory phenotype (SASP) [1]. These RNAs are conserved across a range of species, including humans, and may prove a valuable avenue for controlling senescence. Age-related RNAs RNA can broadly be
Oisín Announces $5 Million in New Seed Funding
May 27, 2021
Today, Oisín Biotechnologies, a well-known developer of senolytics, drugs that destroy harmful senescent cells, has announced that it has more than doubled its total funding through an oversubscribed round. This has taken its total funding from $4.5 million to $9.5 million. Named after a legendary Irish
Cytosolic dsDNA as a Marker of Senescence
May 26, 2021
Senescent cells are surprisingly hard to identify, but a recent publication in Tissue and Cell makes the case for using cytoplasmic DNA as a marker of senescence. What makes a cell senescent? In order to study the behavior of senescent cells, or to treat them with
Overwork Linked to Heart Disease and Stroke
May 25, 2021
In the largest study of its kind to date, researchers have revealed that a considerable part of all deaths from ischemic heart disease and stroke worldwide is caused by working long hours [1]. Beware of Karoshi What can we do to live longer until science can
OSKM in Early Life Increases Lifespan in Mice
May 24, 2021
An article preprint published on bioRxiv shows that a single OSKM treatment in early life provides lifelong benefits in mice. A single reset versus lifetime resetting The team chose a group of heterozygous progeric mice as a mouse model. These mice suffer from a single mutation