Category: News
The APOE4 Gene Is Associated With Worse Stroke Outcomes
January 19, 2023
Researchers publishing in Aging have found that there is a correlation between the APOE4 gene and poor outcomes after ischemic stroke. An allele with a long and sordid history Other
Selfish, Reckless, Satanic: Life Extension in Movies
January 19, 2023
In the much-awaited sequel to the movie Avatar, there is a passing, peculiar mention of life extension. This mention, as can be expected, is negative. In the movie, the greedy,
Questioning the Usefulness of Model Organisms
January 18, 2023
In a new review paper published in GeroScience, the researchers explored the translatability of anti-aging interventions across species and received somewhat alarming results [1]. Necessary, but not the best Model
The Microbiome Might Affect Motivation for Exercise
January 17, 2023
Scientists publishing in Nature have found that compounds produced by some types of gut bacteria can influence dopamine levels in the brain and, as a result, might influence motivation to
NMN Alleviates Silicate Lung Injury in Mice
January 16, 2023
A new paper published in Nutrients shows that the well-known NAD+ precursor NMN alleviates lung injury caused by silicate inhalation in wild-type mice. An antioxidant approach to a common problem
David Sinclair: Epigenetic Info Loss Is a Cause of Aging
January 13, 2023
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it
Obesity Shown to Affect Brain Aging in Mice
January 12, 2023
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The
NAD+ Supplement Protects Intestines from Alcohol in Mice
January 11, 2023
Scientists have shown that the NAD+ precursor nicotinamide riboside (NR) alleviates symptoms of leaky gut caused by ethanol consumption in mice by improving mitochondrial function [1]. Leaky gut drives inflammation
The Hallmarks of Aging’s Original Authors Offer a Fresh View
January 11, 2023
The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks
Aubrey de Grey on LEVF and Robust Mouse Rejuvenation
January 10, 2023
Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS
Gene Therapy to Induce Epigenetic Reprogramming
January 9, 2023
A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice.
Silly Walking for Serious Exercise
January 6, 2023
Researchers have shown that a particular walking style that many people immediately recognize can count as high-intensity exercise [1]. Does exercise have to be boring? In the fight against aging,
Targeting Cdc42 Improves Stem Cells in Old Mice
January 5, 2023
Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain
The APOE4 Gene Is Associated With Worse Stroke Outcomes
January 19, 2023
Researchers publishing in Aging have found that there is a correlation between the APOE4 gene and poor outcomes after ischemic stroke. An allele with a long and sordid history Other than its well-known association with Alzheimer’s disease, the APOE4 allele, which codes for the ApoE4 apolipoprotein
Selfish, Reckless, Satanic: Life Extension in Movies
January 19, 2023
In the much-awaited sequel to the movie Avatar, there is a passing, peculiar mention of life extension. This mention, as can be expected, is negative. In the movie, the greedy, nature-destroying humans hunt a local whale-like species for several ounces of precious liquid secreted by the
Questioning the Usefulness of Model Organisms
January 18, 2023
In a new review paper published in GeroScience, the researchers explored the translatability of anti-aging interventions across species and received somewhat alarming results [1]. Necessary, but not the best Model organisms have been widely and successfully used to understand the molecular processes driving disease pathologies, identify
The Microbiome Might Affect Motivation for Exercise
January 17, 2023
Scientists publishing in Nature have found that compounds produced by some types of gut bacteria can influence dopamine levels in the brain and, as a result, might influence motivation to go on a morning run [1]. We’ve got company We tend to think of ourselves as
NMN Alleviates Silicate Lung Injury in Mice
January 16, 2023
A new paper published in Nutrients shows that the well-known NAD+ precursor NMN alleviates lung injury caused by silicate inhalation in wild-type mice. An antioxidant approach to a common problem Silicosis is an occupational hazard encountered by people who are regularly exposed to silica dust [1].
David Sinclair: Epigenetic Info Loss Is a Cause of Aging
January 13, 2023
Published in Cell, a new paper by David Sinclair and his team argues that epigenetic dysregulation in the form of information loss is a major driver of aging, but it can be reversed in vivo by partial cellular reprogramming. Genome or epigenome? Both genomic instability and
Obesity Shown to Affect Brain Aging in Mice
January 12, 2023
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The researchers introduce this study by discussing human studies. It is well known that obesity is a
NAD+ Supplement Protects Intestines from Alcohol in Mice
January 11, 2023
Scientists have shown that the NAD+ precursor nicotinamide riboside (NR) alleviates symptoms of leaky gut caused by ethanol consumption in mice by improving mitochondrial function [1]. Leaky gut drives inflammation The permeability of the epithelial intestinal barrier is known to increase with age. The resulting condition,
The Hallmarks of Aging’s Original Authors Offer a Fresh View
January 11, 2023
The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks of cancer [1,2]. These papers were authored by the same team that published the original 2013
Aubrey de Grey on LEVF and Robust Mouse Rejuvenation
January 10, 2023
Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS Research Foundation, de Grey made significant contributions to geroscience, and at Longevity Summit Dublin last year,
Gene Therapy to Induce Epigenetic Reprogramming
January 9, 2023
A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice. A new handle on old problems The researchers begin this study with a discussion of the
Silly Walking for Serious Exercise
January 6, 2023
Researchers have shown that a particular walking style that many people immediately recognize can count as high-intensity exercise [1]. Does exercise have to be boring? In the fight against aging, anything goes. As we have reported numerous times, exercise is one of the most effective anti-aging
Targeting Cdc42 Improves Stem Cells in Old Mice
January 5, 2023
Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A protein that suppresses stem cells In both humans and mice, the protein Cdc42 increases with aging.
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is a growing understanding that, just like aging itself, senescence is a complex and heterogeneous phenomenon [2].
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain extreme longevity [1]. Genetics can be friend or foe Centenarians are people who have lived for