Category: Biology of Aging
TFEB Lets Cells Live Long Enough to Become Senescent
May 6, 2025
In Aging Cell, researchers have explained how transcription factor EB (TFEB) is related to cellular senescence and keeps stressed cells alive. Inactivated by mTOR Yesterday, we reported on TFEB’s effects
Limiting One Protein Maintenance Pathway Enhances Another
May 5, 2025
In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model. Maintaining protein function Proteostasis is naturally maintained by a quality control system
Immune Resilience Is a Strong Determinant of Mortality
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to
How Extracellular Vesicles From Stem Cells Fight Senescence
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to
OS-01 Peptide Tested in Skin Aging Pilot Study
April 25, 2025
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the
How Fisetin May Fight Blood Vessel Calcification
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where
Researchers Fight Some Mutations by Targeting Mitochondria
April 22, 2025
Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin [1]. The attack
A Senescence-Related Target for Blood Vessel Formation
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages
Researchers Use Big Data to Find a Longevity Target
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting
Senolytics Decrease Low Back Pain in Mice
April 15, 2025
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain;
Neurons Hidden to Immune Cells Improve Parkinson’s in Rats
April 11, 2025
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. Sneakiness needed In recent years,
How Exercise May Fight Parkinson’s Disease
April 10, 2025
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Fighting inflammation is crucial in Parkinson’s Parkinson’s
Fasting Affects the Immune System via the Brain
April 8, 2025
A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus. The findings could be important in
Reprogramming Epigenetics to Fight Back Pain
April 7, 2025
A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The
World’s First Pig-to-Human Liver Transplant
April 4, 2025
Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient. This represents an important step towards routinely using pig organs to save
TFEB Lets Cells Live Long Enough to Become Senescent
May 6, 2025
In Aging Cell, researchers have explained how transcription factor EB (TFEB) is related to cellular senescence and keeps stressed cells alive. Inactivated by mTOR Yesterday, we reported on TFEB’s effects on proteostasis and how it has downstream functions on protein chaperones. This research, however, focuses on
Limiting One Protein Maintenance Pathway Enhances Another
May 5, 2025
In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model. Maintaining protein function Proteostasis is naturally maintained by a quality control system that utilizes a network of chaperones and co-chaperones in order to handle all aspects of protein
Immune Resilience Is a Strong Determinant of Mortality
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to withstand stress [1]. Keeping the balance Geroscientists have long suspected that the immune system plays an
How Extracellular Vesicles From Stem Cells Fight Senescence
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to senescence The researchers began their paper discussing the well-trodden ground of senolytics, which kill senescent cells,
OS-01 Peptide Tested in Skin Aging Pilot Study
April 25, 2025
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the skin’s barrier function and multiple aging biomarkers [1]. Conducted by a team from OneSkin alongside academic
How Fisetin May Fight Blood Vessel Calcification
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where it doesn’t belong Calcification is not the same as ‘hardening’ of blood vessel walls (atherosclerosis), which
Researchers Fight Some Mutations by Targeting Mitochondria
April 22, 2025
Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin [1]. The attack of the clones The human body constantly produces vast numbers of blood cells from hematopoietic stem
A Senescence-Related Target for Blood Vessel Formation
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages can impair blood vessel formation Heart attack and stroke are not the only problems caused by
Researchers Use Big Data to Find a Longevity Target
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting -omics databases to work These researchers introduce their study by discussing genetic databases, which have previously
Senolytics Decrease Low Back Pain in Mice
April 15, 2025
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain; decreased senescence and disc degeneration; and improvements in vertebral bone quality [1]. A painful global problem
Neurons Hidden to Immune Cells Improve Parkinson’s in Rats
April 11, 2025
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. Sneakiness needed In recent years, scientists have learned to produce cells via cellular reprogramming, a process in which differentiated cells are
How Exercise May Fight Parkinson’s Disease
April 10, 2025
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Fighting inflammation is crucial in Parkinson’s Parkinson’s disease is characterized by Lewy bodies and the loss of dopaminergic neurons [1]. Recent work has
Fasting Affects the Immune System via the Brain
April 8, 2025
A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus. The findings could be important in the context of fasting mimicking, metabolic disorders, and cancer [1]. Fasting and the immune system Decades
Reprogramming Epigenetics to Fight Back Pain
April 7, 2025
A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The soft tissue degrades Nucleus pulposus cells, which maintain the discs in the spine [1], are prone
World’s First Pig-to-Human Liver Transplant
April 4, 2025
Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient. This represents an important step towards routinely using pig organs to save human lives [1]. Where do we get spare parts? The shortage of organs for transplantation is