Category: Biology of Aging
Preventing Alzheimer’s Proteins From Accumulating
November 14, 2024
Boosting a key autophagy-related protein discourages a core component of Alzheimer’s from taking hold, according to a study published in Aging Cell. Taking out the trash Autophagy is the maintenance
A Senolytic Accelerates Reproductive Aging in Aged Mice
November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal
Rejuvenating the Hippocampus With Metabolites
November 11, 2024
Researchers have reported in Aging Cell that injecting specific one-carbon metabolites into the hippocampus can rejuvenate its cells. A small molecule approach Epigenetic alterations have been found to impact the
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations,
Towards Fine-Tuned Control of Gene Expression
November 4, 2024
In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types. More than methylation While methylation is
Senescent Cells Promote Cartilage Regeneration in Rats
October 31, 2024
In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage. Not always negative Cellular senescence is widely
The Fibroblasts That Protect Ovarian Cancer
October 28, 2024
In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer’s natural defenders Ovarian cancer is particularly dangerous, both in death
Neuronal Reprogramming Alleviates Alzheimer’s in Mice
October 25, 2024
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and
A Senolytic Treatment for Liver Sepsis
October 24, 2024
A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging
HAPLN1 in Blood Found to Rejuvenate Skin
October 23, 2024
Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin
Autodigestion From Gut Enzymes May Drive Aging
October 22, 2024
A new study links damage caused by digestive enzymes escaping from the gut to several hallmarks of aging. The researchers dubbed this effect “autodigestion.” [1] Don’t eat yourself up! To
The Reason Why the p16 Senescence Pathway Exists
October 21, 2024
Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don’t produce the senescence-related compound p16. A necessary evil The aging community has published
Scientists Create a Potent Bacterial Anti-Cancer Vaccine
October 18, 2024
A new study describes a novel anti-cancer vaccine based on antigen-producing bacteria that can tackle solid and metastatic cancers [1]. Invading an invader Years ago, scientists discovered that bacteria can
A Potential Target for Post-Surgery Cognitive Impairment
October 17, 2024
In Aging Cell, researchers have identified a receptor in the brain that appears to be responsible for cognitive problems after surgery, particularly in older people. Surgery can cause cognitive problems
Preventing Alzheimer’s Proteins From Accumulating
November 14, 2024
Boosting a key autophagy-related protein discourages a core component of Alzheimer’s from taking hold, according to a study published in Aging Cell. Taking out the trash Autophagy is the maintenance process of the cell, in which autophagosomes engulf unwanted organelles and other material and fuse together
A Senolytic Accelerates Reproductive Aging in Aged Mice
November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal levels, further depleted ovarian reserves, and didn’t improve most of the tested signs of reproductive aging
Rejuvenating the Hippocampus With Metabolites
November 11, 2024
Researchers have reported in Aging Cell that injecting specific one-carbon metabolites into the hippocampus can rejuvenate its cells. A small molecule approach Epigenetic alterations have been found to impact the neuroplasticity of the brain, leading to problems with learning and memory [1]. This research team has
Extracellular Vesicles for Treating Arthritis
November 7, 2024
A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells’ function Excessive senescent cell buildup in cartilage has negative effects and leads to osteoarthritis [1]. Constant exposure to SASP factors
Mesenchymal Stem Cells Rejuvenate Aged Mice
November 6, 2024
In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness [1]. Therapeutic potential Earlier this year, we reported
Towards Fine-Tuned Control of Gene Expression
November 4, 2024
In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types. More than methylation While methylation is the most well-known regulator of gene expression, it isn’t the only thing that determines what is
Senescent Cells Promote Cartilage Regeneration in Rats
October 31, 2024
In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage. Not always negative Cellular senescence is widely known to have negative effects, to the point that it is one of the hallmarks of
The Fibroblasts That Protect Ovarian Cancer
October 28, 2024
In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer’s natural defenders Ovarian cancer is particularly dangerous, both in death rates and in recurrence [1]. Normally, chemicals that contain platinum are effective, but this sort of
Neuronal Reprogramming Alleviates Alzheimer’s in Mice
October 25, 2024
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and space Partial cellular reprogramming is one of the hottest directions in longevity research for a reason:
A Senolytic Treatment for Liver Sepsis
October 24, 2024
A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging Sepsis, an inflammatory condition most commonly known as blood poisoning, is the most common cause of
HAPLN1 in Blood Found to Rejuvenate Skin
October 23, 2024
Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin [1]. The most noticeable sign of aging Skin aging, one of the most visible forms of
Autodigestion From Gut Enzymes May Drive Aging
October 22, 2024
A new study links damage caused by digestive enzymes escaping from the gut to several hallmarks of aging. The researchers dubbed this effect “autodigestion.” [1] Don’t eat yourself up! To live, we must eat, which involves breaking down compounds that we ourselves consist of, such as
The Reason Why the p16 Senescence Pathway Exists
October 21, 2024
Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don’t produce the senescence-related compound p16. A necessary evil The aging community has published a lot of papers on p16INK4a (p16) and its SASP-associated dangers, as excessive SASP production is
Scientists Create a Potent Bacterial Anti-Cancer Vaccine
October 18, 2024
A new study describes a novel anti-cancer vaccine based on antigen-producing bacteria that can tackle solid and metastatic cancers [1]. Invading an invader Years ago, scientists discovered that bacteria can colonize tumors [2]. Some bacteria are drawn to the tumor microenvironment due to factors such as
A Potential Target for Post-Surgery Cognitive Impairment
October 17, 2024
In Aging Cell, researchers have identified a receptor in the brain that appears to be responsible for cognitive problems after surgery, particularly in older people. Surgery can cause cognitive problems Neurological symptoms such as postoperative cognitive dysfunction [1] and postoperative delirium [2] are common after surgery,