Category: Biology of Aging
Blueberry Extract Aids Cognition in People With Inflammation
October 16, 2024
A reanalysis of data from a previous study identified a difference between people with low and high levels of inflammatory biomarkers. The cognitive performance of people with high levels of
Heart Organoids Flown to Space Show Signs of Dysfunction
October 15, 2024
Scientists have found that human heart tissue is harmed by even a short stint in orbit. This might have implications for future space travel [1]. Fly me to the Moon
The Chemical Reasons Why Visceral Fat Is Dangerous
October 14, 2024
In Aging Cell, researchers have described the chemical ways in which excessive visceral fat causes oxidative stress and cellular senescence. Visceral fat is metabolically active Metabolic syndrome, a host of
Exosomes Break Rat Lifespan Record
October 10, 2024
In Aging Cell, researchers have published their findings that exosomes, which we have previously reported to extend the lives of mice, also extend the lives of rats. Known to be
Cryptic Exons for Targeting Neurodegenerative Disease
October 8, 2024
Amyotrophic lateral sclerosis (ALS) only affects a fraction of cells and must be treated with high specificity. Scientists have achieved that by targeting mRNA sites associated with the disease [1].
Senescent Macrophages: A Unique Target
October 7, 2024
In Aging, researchers have published a new study on a tool meant for analyzing macrophage senescence along with differences between inflammaging and regular inflammation. Macrophages are driven to senescence Previous
mTOR and SGLT-2 Inhibitors Impact Age-Related Processes
October 2, 2024
The authors of a recent review propose that there may be positive synergistic effects from combining mTOR inhibitors and sodium-glucose co-transporter-2 (SGLT-2) inhibitors [1]. Inhibition of two molecules is better
Boosting Autophagy in Astrocytes Might Help Cure Alzheimer’s
October 1, 2024
With Alzheimer’s disease, most of the focus has been on neurons. A new study’s researchers suggest boosting the process of cellular junk removal in astrocytes, brain cells that perform maintenance
How Lifesaving Treatments Can Cause Long-Term Harm
September 30, 2024
A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs
Study Suggests Mammals’ Lifespan Is Limited by Epigenetics
September 30, 2024
Juan José Alba-Linares and his research team have published a preprint study that examined why different animals age at different rates. They found that epigenetic changes over time could explain
A Bank of Centenarian Stem Cells
September 29, 2024
Researchers are keeping a bank of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the purpose of this bank and its uses in Aging Cell.
Reprogramming Senescent Cells Extends Lifespan in Mice
September 27, 2024
Dr. Belmonte’s group at Altos Labs targeted stressed and senescent cells with partial reprogramming, producing large increases in lifespan in male mice [1]. What are they doing there? Since the
A Likely Beneficial Compound Also Predicts Mortality
September 26, 2024
Researchers publishing in Aging have found that fibroblast growth factor 21 (FGF21), an apparently beneficial protein naturally produced by the human body, heralds a greater likelihood of death. Multiple documented
Metformin Slows Aging in Non-Human Primates
September 26, 2024
In a new study, metformin, which has already shown good results in rodents and in human epidemiological studies, alleviated multiple signs of aging in male cynomolgus monkeys [1]. Now in
MSC Treatment Improves Age-Related Phenotypes in Rats
September 25, 2024
In a recent study, researchers injected rats with mesenchymal stromal cells. They observed improvements in aging-related biomarkers and phenotypes in many organs [1]. The rejuvenating role of MSCs Mesenchymal stromal
Blueberry Extract Aids Cognition in People With Inflammation
October 16, 2024
A reanalysis of data from a previous study identified a difference between people with low and high levels of inflammatory biomarkers. The cognitive performance of people with high levels of inflammation improved after they consumed anthocyanin supplements [1]. Inflammation and dementia Dementia is a complex disorder
Heart Organoids Flown to Space Show Signs of Dysfunction
October 15, 2024
Scientists have found that human heart tissue is harmed by even a short stint in orbit. This might have implications for future space travel [1]. Fly me to the Moon Space exploration is cool, but the human body was obviously not made for it. All its
The Chemical Reasons Why Visceral Fat Is Dangerous
October 14, 2024
In Aging Cell, researchers have described the chemical ways in which excessive visceral fat causes oxidative stress and cellular senescence. Visceral fat is metabolically active Metabolic syndrome, a host of intertwined disorders that include obesity and cholesterol imbalance, is known to have multiple harmful effects that
Exosomes Break Rat Lifespan Record
October 10, 2024
In Aging Cell, researchers have published their findings that exosomes, which we have previously reported to extend the lives of mice, also extend the lives of rats. Known to be effective Exosomes, a subset of extracellular vesicles (EVs), can be visualized as messages and packages that
Cryptic Exons for Targeting Neurodegenerative Disease
October 8, 2024
Amyotrophic lateral sclerosis (ALS) only affects a fraction of cells and must be treated with high specificity. Scientists have achieved that by targeting mRNA sites associated with the disease [1]. Cryptic behavior ALS is a neurodegenerative disease in which age is a major factor. While it
Senescent Macrophages: A Unique Target
October 7, 2024
In Aging, researchers have published a new study on a tool meant for analyzing macrophage senescence along with differences between inflammaging and regular inflammation. Macrophages are driven to senescence Previous work has found that excessive senescent cells are uniquely harmful to macrophages, recruiting them into senescence
mTOR and SGLT-2 Inhibitors Impact Age-Related Processes
October 2, 2024
The authors of a recent review propose that there may be positive synergistic effects from combining mTOR inhibitors and sodium-glucose co-transporter-2 (SGLT-2) inhibitors [1]. Inhibition of two molecules is better than one mTOR is a well-known molecule in aging research. Inhibition of mTOR has been shown
Boosting Autophagy in Astrocytes Might Help Cure Alzheimer’s
October 1, 2024
With Alzheimer’s disease, most of the focus has been on neurons. A new study’s researchers suggest boosting the process of cellular junk removal in astrocytes, brain cells that perform maintenance tasks, as a new pathway [1]. Looking at a different cell type Accumulation of amyloid beta,
How Lifesaving Treatments Can Cause Long-Term Harm
September 30, 2024
A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs and breast cancer treatment are lifesaving procedures. However, chemotherapy in breast cancer sharply increases p16INK4a, a
Study Suggests Mammals’ Lifespan Is Limited by Epigenetics
September 30, 2024
Juan José Alba-Linares and his research team have published a preprint study that examined why different animals age at different rates. They found that epigenetic changes over time could explain why some animals live longer and estimated an upper limit for mammalian lifespan [1]. A problem
A Bank of Centenarian Stem Cells
September 29, 2024
Researchers are keeping a bank of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the purpose of this bank and its uses in Aging Cell. A category of their own Centenarians don’t merely live for a hundred years; they spend more
Reprogramming Senescent Cells Extends Lifespan in Mice
September 27, 2024
Dr. Belmonte’s group at Altos Labs targeted stressed and senescent cells with partial reprogramming, producing large increases in lifespan in male mice [1]. What are they doing there? Since the discovery of cellular reprogramming almost two decades ago, a lot of hopes have been put into
A Likely Beneficial Compound Also Predicts Mortality
September 26, 2024
Researchers publishing in Aging have found that fibroblast growth factor 21 (FGF21), an apparently beneficial protein naturally produced by the human body, heralds a greater likelihood of death. Multiple documented benefits FGF21 plays crucial roles in the human body. Secreted by the liver and many other
Metformin Slows Aging in Non-Human Primates
September 26, 2024
In a new study, metformin, which has already shown good results in rodents and in human epidemiological studies, alleviated multiple signs of aging in male cynomolgus monkeys [1]. Now in monkeys Metformin, a well-established anti-diabetes drug, has been touted as a possible geroprotector since a study
MSC Treatment Improves Age-Related Phenotypes in Rats
September 25, 2024
In a recent study, researchers injected rats with mesenchymal stromal cells. They observed improvements in aging-related biomarkers and phenotypes in many organs [1]. The rejuvenating role of MSCs Mesenchymal stromal cells (MSCs) can be obtained from diverse sources, including bone marrow, adipose tissue, perinatal tissue, and