Category: Biology of Aging
One Reason Why Older People Have Chronic Pain
May 20, 2024
Researchers have discovered a compound and a brain region that may be related to chronic pain in older people and published their findings in Aging Cell. When one sense doesn’t
Plant Virus Nanoparticles Prevent Metastatic Cancers
May 17, 2024
Scientists have demonstrated that viral particles from a harmless plant virus can be used as an adjuvant therapy to prevent recurrence of disease and metastasis formation in several cancer models
Stem Cell Transplants for Ovarian Aging
May 15, 2024
Experiments in mouse models show the efficacy and safety of mesenchymal stem cell transplantation in treating ovarian aging [1]. Mesenchymal stem cells as a therapy Mesenchymal stem cells (MSCs) are
Aged Bacteria Increase Gut Inflammation in Younger Animals
May 13, 2024
Researchers have discovered negative ways in which intestinal bacteria change over time, spurring gut inflammation, and introduced older bacteria into a population of younger mice to determine their effects. A
iPSC-derived Cardiomyocytes Rescue Heart Damage in Monkeys
May 10, 2024
Scientists have successfully used heart muscle cells created from induced pluripotent stem cells to counter the deleterious effects of heart attack in non-human primates. Reprogrammed cells for heart regeneration Since
Clearing Senescent Cells Can Be a Double-Edged Sword
May 9, 2024
Researchers have found that removing senescent cells makes it easier for mice to fight initial infections but harder for them to develop immune memory. Senescence and immunity Introducing their paper,
Longevity and DeSci Recap – April 2024
May 8, 2024
In this latest edition of the Longevity and DeSci Recap, we’ll be taking a look back over a month full of events, research, and investments. As we head into spring,
NMN and NR Reverse Ovarian Aging in Rats
May 8, 2024
In a recent Pharmaceutical Research paper, the researchers explored the molecular processes through which the NAD+ precursors NMN and NR reversed ovarian aging in middle-aged rats [1]. Use it or
Exploring How Caloric Restriction Impacts Telomere Length
May 7, 2024
A recent study from Penn State University may shed more light on the link between telomeres, aging, and why caloric restriction appears to influence them. Telomeres are linked to aging
A New Potential Path to Treating Kidney Fibrosis
May 6, 2024
Researchers have found a new protein target for senescence-related kidney diseases and published their findings in Aging Cell. Kidney disease and fatty acid use Chronic kidney disease (CKD) is all
Transplanting Mitochondria Improves Muscle Function
May 3, 2024
A recent study saw researchers associated with Cellvie demonstrate significant improvements to mitochondria and muscle function in aged mice by injecting additional mitochondria [1]. Mitochondrial dysfunction is a reason we
Stem Cells Alleviate Frailty in Clinical Trial
May 2, 2024
A placebo-controlled Phase 1/2 trial conducted in East Shanghai has found that administering umbilical cord-derived mesenchymal stem cells reduces frailty in older people. Stem cells against frailty These researchers begin
A Protein Potently Suppresses Lung Cancer in Mice
April 30, 2024
Scientists have identified the proteins FOXF1 and its downstream target FZD4 as potential targets for treating lung cancer. Upregulating them helps to normalize vasculature in the tumor area and suppresses
Older and Younger Cells Handle Genes Differently
April 29, 2024
In Aging Cell, researchers have published evidence that downregulating a key aspect of lipid metabolism harms mitochondrial function, but only in cells taken from younger people. Fat regulation at the
Looking for Causality in Diabetes and Aging
April 25, 2024
Researchers have published the results of a study in Aging Cell, finding some evidence that type 2 diabetes causes accelerated aging. Later-generation clocks only This paper begins with explanations of
One Reason Why Older People Have Chronic Pain
May 20, 2024
Researchers have discovered a compound and a brain region that may be related to chronic pain in older people and published their findings in Aging Cell. When one sense doesn’t decline Aging destroys the senses over time, most notably sight and hearing [1]. Sensations related to
Plant Virus Nanoparticles Prevent Metastatic Cancers
May 17, 2024
Scientists have demonstrated that viral particles from a harmless plant virus can be used as an adjuvant therapy to prevent recurrence of disease and metastasis formation in several cancer models [1]. The challenge of keeping cancer at bay Medicine’s progress in treating cancer has been patchy:
Stem Cell Transplants for Ovarian Aging
May 15, 2024
Experiments in mouse models show the efficacy and safety of mesenchymal stem cell transplantation in treating ovarian aging [1]. Mesenchymal stem cells as a therapy Mesenchymal stem cells (MSCs) are stem cells derived from mesodermal tissue, such as the umbilical cord, umbilical cord blood, the placenta,
Aged Bacteria Increase Gut Inflammation in Younger Animals
May 13, 2024
Researchers have discovered negative ways in which intestinal bacteria change over time, spurring gut inflammation, and introduced older bacteria into a population of younger mice to determine their effects. A well-known link It has been thoroughly documented that gut bacteria have an influence on aging [1],
iPSC-derived Cardiomyocytes Rescue Heart Damage in Monkeys
May 10, 2024
Scientists have successfully used heart muscle cells created from induced pluripotent stem cells to counter the deleterious effects of heart attack in non-human primates. Reprogrammed cells for heart regeneration Since Dr. Yamanaka’s discovery, there has been a massive effort to turn this discovery into working therapies,
Clearing Senescent Cells Can Be a Double-Edged Sword
May 9, 2024
Researchers have found that removing senescent cells makes it easier for mice to fight initial infections but harder for them to develop immune memory. Senescence and immunity Introducing their paper, the researchers discuss the SASP and the relationship of senescent cells to the immune system, noting
Longevity and DeSci Recap – April 2024
May 8, 2024
In this latest edition of the Longevity and DeSci Recap, we’ll be taking a look back over a month full of events, research, and investments. As we head into spring, renewed life is on the horizon with continued investments in the longevity sector and the announcement
NMN and NR Reverse Ovarian Aging in Rats
May 8, 2024
In a recent Pharmaceutical Research paper, the researchers explored the molecular processes through which the NAD+ precursors NMN and NR reversed ovarian aging in middle-aged rats [1]. Use it or lose it Female fertility decreases rather quickly in life. Aging leads to a decrease in the
Exploring How Caloric Restriction Impacts Telomere Length
May 7, 2024
A recent study from Penn State University may shed more light on the link between telomeres, aging, and why caloric restriction appears to influence them. Telomeres are linked to aging Telomeres are small protective caps on the ends of our chromosomes that guard our DNA. Telomere
A New Potential Path to Treating Kidney Fibrosis
May 6, 2024
Researchers have found a new protein target for senescence-related kidney diseases and published their findings in Aging Cell. Kidney disease and fatty acid use Chronic kidney disease (CKD) is all too common in older people, as a full third of people over 70 have moderate to
Transplanting Mitochondria Improves Muscle Function
May 3, 2024
A recent study saw researchers associated with Cellvie demonstrate significant improvements to mitochondria and muscle function in aged mice by injecting additional mitochondria [1]. Mitochondrial dysfunction is a reason we age Mitochondria are cellular powerhouses that convert nutrients into adenosine triphosphate (ATP), a form of energy
Stem Cells Alleviate Frailty in Clinical Trial
May 2, 2024
A placebo-controlled Phase 1/2 trial conducted in East Shanghai has found that administering umbilical cord-derived mesenchymal stem cells reduces frailty in older people. Stem cells against frailty These researchers begin by defining frailty as “a state of heightened vulnerability to potential stressors as a consequence of
A Protein Potently Suppresses Lung Cancer in Mice
April 30, 2024
Scientists have identified the proteins FOXF1 and its downstream target FZD4 as potential targets for treating lung cancer. Upregulating them helps to normalize vasculature in the tumor area and suppresses this lethal type of cancer [1]. Lung cancer and vasculature Lung cancer remains one of the
Older and Younger Cells Handle Genes Differently
April 29, 2024
In Aging Cell, researchers have published evidence that downregulating a key aspect of lipid metabolism harms mitochondrial function, but only in cells taken from younger people. Fat regulation at the cellular level Perilipins (PLINs) are proteins that regulate the use of fats (lipids) within cells. This
Looking for Causality in Diabetes and Aging
April 25, 2024
Researchers have published the results of a study in Aging Cell, finding some evidence that type 2 diabetes causes accelerated aging. Later-generation clocks only This paper begins with explanations of Type 2 diabetes and epigenetic clocks, noting that principal component (PC) versions of clocks may give