Category: Biology of Aging
Nanoparticles Improve Intercellular Mitochondrial Transfer
November 24, 2025
Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult
How Senescent Cells Encourage Melanoma Growth
November 20, 2025
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. Why older people have significantly worse melanoma cases While melanoma
The Impact of Plant Polyphenols on Ovarian Aging
November 19, 2025
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation
Improved Stem Cells Rejuvenate the Brains of Monkeys
November 18, 2025
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Making
A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin
November 17, 2025
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able
NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing
November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Which way to splice it? Not every part
The Key Questions of Longevity Research
November 13, 2025
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature
Multilingualism Is Associated With Delayed Aging
November 12, 2025
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign
New Gene Therapy Robustly Lowers LDL and Triglycerides
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and
High-Fiber Foods May Fight T Cell Senescence
November 10, 2025
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Senescence of the immune system (immunosenescence) is a
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping
Nanoparticles Improve Intercellular Mitochondrial Transfer
November 24, 2025
Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult to improve Energy is required for life, and most energy in our cells is produced by
How Senescent Cells Encourage Melanoma Growth
November 20, 2025
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. Why older people have significantly worse melanoma cases While melanoma is much more treatable now than in the past, it still remains a serious danger. Melanoma
The Impact of Plant Polyphenols on Ovarian Aging
November 19, 2025
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation could be used as an intervention to delay ovarian aging [1]. Every woman’s problem Ovarian aging
Improved Stem Cells Rejuvenate the Brains of Monkeys
November 18, 2025
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Making aging-resistant cells Stem cell exhaustion is one of the mechanisms of aging. Replenishing the aging stem
A Sarcopenia-Related MicroRNA May Help Pinpoint Its Origin
November 17, 2025
In Aging Cell, researchers have discovered a potential way to use a microRNA to diagnose sarcopenia, the age-related loss of muscle. Primary and secondary sarcopenia Previous research has been able to distinguish sarcopenia by its sources. Primary sarcopenia directly comes from the processes of aging, while
NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing
November 14, 2025
A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer’s [1]. Which way to splice it? Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are
The Key Questions of Longevity Research
November 13, 2025
In GeroScience, a large team of researchers, including João Pedro de Magalhães, has described a hundred currently unsolved problems in the field. Finding the right questions Understanding the fundamental nature of aging has been a problem since people first endeavored to live longer, to the point
Multilingualism Is Associated With Delayed Aging
November 12, 2025
A recent study of over 80,000 Europeans concluded that speaking more than one language is associated with delayed aging. Further analysis suggested that the protective effect of speaking one foreign language diminished with age, while the protective effect of speaking two or more foreign languages was
New Gene Therapy Robustly Lowers LDL and Triglycerides
November 11, 2025
A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and reduce side effects [1]. Addressing the adherence problem High levels of LDL cholesterol (LDL-C) and triglycerides
High-Fiber Foods May Fight T Cell Senescence
November 10, 2025
Researchers have discovered that butyrate, a short-chain fatty acid with well-documented gut benefits, fights senescence in T cells. Immune senescence drives inflammaging Senescence of the immune system (immunosenescence) is a problem that drives many others. In particular, T cells are known to secrete inflammatory SASP compounds
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s [1]. Dangerous species Reactive oxygen species (ROS) are short-lived, highly reactive oxygen-containing
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein with documented harmful effects, this one is required for certain systems to function properly. The EDA
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin restored this balance and increased fertility rates in a human trial [1]. The first system to
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions [1]. Macrophages, capillaries, and skin aging Skin aging might not be the most dangerous aspect of
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping cells healthy The researchers introduce their paper by discussing autophagy and its decline in aging. They