Category: Research
How Spaceflight Alters the Rate of Aging
August 23, 2023
A review published in Aging Cell has explored the impact of spaceflight on human and other organisms’ health and aging [1]. Hazards of spaceflight Will sending humans to space make
A Protective Mechanism Against AMD
August 22, 2023
A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins
Figuring Out Why Stem Cells Won’t Build Bone
August 21, 2023
Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don’t differentiate into bone-building osteoblasts, unlocking a potential new approach to
Antioxidants Rescue Cognitive Decline in Mice
August 18, 2023
Scientists have found that EGCG and curcumin, two well-known antioxidants, are effective both alone and especially in combination in a mouse model of cognitive decline induced by oxidative stress [1].
Extracellular Vesicles from Stem Cells Reverse Senescence
August 15, 2023
Scientists have found that bubbles secreted by embryonic stem cells counter cellular senescence, in large part due to just two tiny snippets of RNA [1]. Helpful bubbles Extracellular vesicles (EVs)
Restoring Helper Cell Function to Fight Alzheimer’s
August 14, 2023
In a study published in Cell Stem Cell, researchers have investigated a way to repopulate the brain with functional cells in order to fight back against Alzheimer’s disease. A gene
New Senolytics from Artificial Intelligence
August 9, 2023
Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1]. Searching for new senolytics Senolytics are molecules that destroy
Liquid Metal Nanoparticles Eradicate Colon Cancer in Mice
August 9, 2023
Scientists have combined gallium nanoparticles with immunotherapy agents to deliver a decisive blow to colon cancer tumors in mice [1]. Cancer, you are terminated Most moviegoers are familiar with the
The Inflammatory Pathway to Brain Damage
August 7, 2023
Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating
The Flavonoid Rutin May Suppress Senescent Cells
August 3, 2023
Researchers publishing in Aging Cell have documented some potential effects of rutin against senescence and cancer. Rutin is a natural compound found in several plants. Another compound to fight senescence
Impaired Calcium Uptake May Impact Long-Term Inflammation
August 3, 2023
Scientists have reported in Nature Aging that impaired mitochondrial uptake of calcium ions leads to changes in inflammatory responses that resemble what happens in aging [1]. Inflammation and aging Inflammation
Heterochronic Parabiosis Extends the Lives of Mice
August 1, 2023
For the first time, scientists have shown that letting young and old mice share blood leads to a significant lifespan extension in the old mouse [1]. Rejuvenation by young blood
Genetically Engineering Cells to Respond to Electricity
July 31, 2023
A paper published today in Nature Metabolism has described a method of genetically engineering cells to respond to electrical stimuli, allowing for on-demand gene expression. Finding a better trigger Despite
Young Brain Cells Outcompete Old Cells in a Mouse Model
July 28, 2023
In a mouse model of Huntington’s disease, scientists showed that injected young healthy brain cells can outcompete and eventually replace old, diseased ones. The results might be relevant for other
Neil Riordan on the Rising Tide of Stem Cell Therapies
July 27, 2023
“Stem Cell Therapy: A Rising Tide” by Neil Riordan is a comprehensive exploration of stem cell therapy along with its potential benefits, limitations, and prospects. The father of mesenchymal stem
How Spaceflight Alters the Rate of Aging
August 23, 2023
A review published in Aging Cell has explored the impact of spaceflight on human and other organisms’ health and aging [1]. Hazards of spaceflight Will sending humans to space make them age slower or faster? Will they be healthier, or will their health suffer? As space
A Protective Mechanism Against AMD
August 22, 2023
A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins with a discussion of AMD and its prevalence. AMD is the most common cause of vision
Figuring Out Why Stem Cells Won’t Build Bone
August 21, 2023
Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don’t differentiate into bone-building osteoblasts, unlocking a potential new approach to osteoporosis. A matter of cellular fate MSCs are downstream of pluripotent stem cells: they can differentiate
Antioxidants Rescue Cognitive Decline in Mice
August 18, 2023
Scientists have found that EGCG and curcumin, two well-known antioxidants, are effective both alone and especially in combination in a mouse model of cognitive decline induced by oxidative stress [1]. Not the usual stress Oxidative stress results mostly from molecules called reactive oxygen species (ROS), which
Extracellular Vesicles from Stem Cells Reverse Senescence
August 15, 2023
Scientists have found that bubbles secreted by embryonic stem cells counter cellular senescence, in large part due to just two tiny snippets of RNA [1]. Helpful bubbles Extracellular vesicles (EVs) are membrane-bound tiny bubbles that are loaded with various molecular cargo, such as proteins, DNA, or
Restoring Helper Cell Function to Fight Alzheimer’s
August 14, 2023
In a study published in Cell Stem Cell, researchers have investigated a way to repopulate the brain with functional cells in order to fight back against Alzheimer’s disease. A gene with a microglial function Various allelles of the apolipoprotein E (APOE) genes are well-known for their
New Senolytics from Artificial Intelligence
August 9, 2023
Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1]. Searching for new senolytics Senolytics are molecules that destroy senescent cells. Only a small number of such molecules have been identified, and only two have
Liquid Metal Nanoparticles Eradicate Colon Cancer in Mice
August 9, 2023
Scientists have combined gallium nanoparticles with immunotherapy agents to deliver a decisive blow to colon cancer tumors in mice [1]. Cancer, you are terminated Most moviegoers are familiar with the liquid metal T-1000 from the Terminator series, and everyone knows about mercury, a liquid metal that
The Inflammatory Pathway to Brain Damage
August 7, 2023
Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating a cause-and-effect relationship between initial damage and long-term effects. Perturbed mitochondria release their mitochondrial DNA (mtDNA)
The Flavonoid Rutin May Suppress Senescent Cells
August 3, 2023
Researchers publishing in Aging Cell have documented some potential effects of rutin against senescence and cancer. Rutin is a natural compound found in several plants. Another compound to fight senescence In this study, the researchers place rutin among the many other natural compounds that have demonstrated
Impaired Calcium Uptake May Impact Long-Term Inflammation
August 3, 2023
Scientists have reported in Nature Aging that impaired mitochondrial uptake of calcium ions leads to changes in inflammatory responses that resemble what happens in aging [1]. Inflammation and aging Inflammation is an essential, evolutionarily conserved process and a fundamental part of the immune response, providing immediate
Heterochronic Parabiosis Extends the Lives of Mice
August 1, 2023
For the first time, scientists have shown that letting young and old mice share blood leads to a significant lifespan extension in the old mouse [1]. Rejuvenation by young blood Since the dawn of civilization, young blood has been credited with healing and rejuvenating powers, and
Genetically Engineering Cells to Respond to Electricity
July 31, 2023
A paper published today in Nature Metabolism has described a method of genetically engineering cells to respond to electrical stimuli, allowing for on-demand gene expression. Finding a better trigger Despite its futuristic outlook, this line of research is built upon previous work. The idea of an
Young Brain Cells Outcompete Old Cells in a Mouse Model
July 28, 2023
In a mouse model of Huntington’s disease, scientists showed that injected young healthy brain cells can outcompete and eventually replace old, diseased ones. The results might be relevant for other neurodegenerative diseases [1]. When neurons’ helpers fail The non-neuronal cells in the brain are collectively known
Neil Riordan on the Rising Tide of Stem Cell Therapies
July 27, 2023
“Stem Cell Therapy: A Rising Tide” by Neil Riordan is a comprehensive exploration of stem cell therapy along with its potential benefits, limitations, and prospects. The father of mesenchymal stem cell research, Arnold Caplan, dubbed Riordan as a pioneering figure in stem cell research and application.