Category: Research
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a
Insilico Unveils Portfolio of Unique Cardiometabolic Assets
November 7, 2025
Nov 7, 2025 – Insilico Medicine (“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the launch of its innovative cardiometabolic disease portfolio of unique
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping
Organ Fat Is Associated With Carotid Atherosclerosis
October 29, 2025
A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjusting for cardiovascular
Review Links Lingering Infections to Senescence
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections,
Stiff Collagen May Lead to Senescent Cells
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known
Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice
October 24, 2025
A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a possible route
Measuring Dog Aging With Protein Metabolism
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages
Addressing Age-Related Vision Decline With Lipid Supplements
October 22, 2025
Researchers have partially reversed age-related vision decline in mice by injecting lipids directly into the retina [1]. The lipids in the retina The membranes that surround our cells are made
Tiny Brain Organoids Show Promise in Alzheimer’s Research
October 21, 2025
Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells (iPSCs) [1]. Beyond
How Being in Orbit Affects Stem Cells
October 20, 2025
In Cell Stem Cell, researchers from the Cedars-Sinai Medical Center have published a review discussing what experiments conducted in space can do for stem cell research and medical research as
Female-Specific Mechanism of Neurodegeneration Discovered
October 17, 2025
Scientists have found that a gene on the X chromosome, which escapes silencing, promotes inflammation and neurodegeneration in a mouse model of multiple sclerosis, but the effects can be reversed
Mice With Reduced Astrocytic Oxidative Stress Live Longer
November 7, 2025
Scientists have discovered that directly reducing the production of reactive oxygen species (ROS) at their source in astrocytes, mitochondrial complex III, improves neuronal health and significantly increases lifespan in a mouse model of Alzheimer’s [1]. Dangerous species Reactive oxygen species (ROS) are short-lived, highly reactive oxygen-containing
Insilico Unveils Portfolio of Unique Cardiometabolic Assets
November 7, 2025
Nov 7, 2025 – Insilico Medicine (“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced the launch of its innovative cardiometabolic disease portfolio of unique highly-differentiated molecules discovered using generative AI. Powered by Insilico’s proprietary end-to-end Pharma.AI platform, the portfolio covers
EDA2R May Be an Aging Biomarker and Inflammaging Target
November 6, 2025
A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein with documented harmful effects, this one is required for certain systems to function properly. The EDA
Rapamycin May Delay Age-Related Fertility Decline
November 5, 2025
In a recent study, researchers identified that an increase in the expression of ribosome-related genes and a loss of protein homeostasis contribute to the age-related decline in female fertility. Rapamycin restored this balance and increased fertility rates in a human trial [1]. The first system to
Skin Aging Underlined by Loss of Capillary Macrophages
November 4, 2025
A new study ties the disappearance of capillary-associated macrophages to age-related vascular degeneration in the skin. Boosting their function with a growth factor offers a possible avenue for anti-aging interventions [1]. Macrophages, capillaries, and skin aging Skin aging might not be the most dangerous aspect of
Maintenance Stays Efficient in Healthy Older People’s Cells
October 30, 2025
Researchers publishing in Aging Cell have found that the efficiency of autophagy, a cellular maintenance process, increases rather than decreases in some T cells derived from healthy older people. Keeping cells healthy The researchers introduce their paper by discussing autophagy and its decline in aging. They
Organ Fat Is Associated With Carotid Atherosclerosis
October 29, 2025
A recent study discovered an association between visceral and, to a lesser extent, hepatic fat with cardiovascular risk factors and carotid atherosclerosis. This association persists even after adjusting for cardiovascular risk factors [1]. Beyond BMI Body mass index (BMI) is a metric that compares height to
Review Links Lingering Infections to Senescence
October 28, 2025
In a comprehensive review, scientists discuss the various mechanisms by which chronic infections drive cellular senescence and aging [1]. Lurking in the body People are mostly aware of acute infections, such as the common cold, COVID-19, and malaria. Science has made great strides against these kinds
Stiff Collagen May Lead to Senescent Cells
October 27, 2025
A preprint study has found that the stiffness of the extracellular matrix (ECM) itself encourages cells to undergo senescence. An unexplored relationship ECM stiffness and cellular senescence are both well-known aspects of aging. The cross-linked collagens, such as glucosepane, that lead to a less-flexible ECM accumulate
Amyloid-Fibrinogen Complexes Exacerbate Alzheimer’s in Mice
October 24, 2025
A study from Rockefeller University suggests that an unholy duo of two proteins causes harm in much lower concentrations than either of them alone. This points to a possible route for intervention [1]. When amyloid met fibrinogen Amyloid beta (Aβ) and tau proteins are the usual
Measuring Dog Aging With Protein Metabolism
October 23, 2025
Researchers working with data from the Dog Aging Project have found that post-translationally modified amino acids (ptmAAs), which are generated from protein metabolism, are useful in determining the biological ages of dogs. The Dog Aging Project With enrollment beginning in 2020, the Dog Aging Project (DAP)
Addressing Age-Related Vision Decline With Lipid Supplements
October 22, 2025
Researchers have partially reversed age-related vision decline in mice by injecting lipids directly into the retina [1]. The lipids in the retina The membranes that surround our cells are made of lipids and proteins. The composition of lipids, which changes as we age, impacts many biophysical
Tiny Brain Organoids Show Promise in Alzheimer’s Research
October 21, 2025
Scientists have developed a novel multicellular integrated brain model to study neurological diseases, incorporating all six major brain cell types derived from patient-specific induced pluripotent stem cells (iPSCs) [1]. Beyond organoids Organoids, tiny lab-grown patches of tissue, are a promising tool for accelerating medical research [2].
How Being in Orbit Affects Stem Cells
October 20, 2025
In Cell Stem Cell, researchers from the Cedars-Sinai Medical Center have published a review discussing what experiments conducted in space can do for stem cell research and medical research as a whole. Cells behave differently in microgravity The gravitational effects of freefalling in orbit are very
Female-Specific Mechanism of Neurodegeneration Discovered
October 17, 2025
Scientists have found that a gene on the X chromosome, which escapes silencing, promotes inflammation and neurodegeneration in a mouse model of multiple sclerosis, but the effects can be reversed with metformin. Human RNA sequencing data supports these findings [1]. Why are women more vulnerable? Multiple