Category: Research
A Look at Idiopathic Pulmonary Fibrosis
June 21, 2021
A new review published in the American Journal of Respiratory Cell and Molecular Biology discusses the causes of, and potential treatments for, idiopathic pulmonary fibrosis (IPF). Fibrosis, but not focused
The Aged Microenvironment Linked to Sarcopenia
June 17, 2021
Muscular degradation with age isn’t the result of a decline in the intrinsic regenerative ability of muscles, according to new research [1]. Instead, sarcopenia is likely due to changes in
Brain Blood Flow Restriction Resembles Brain Aging in Mice
June 16, 2021
A mouse study published in Aging Cell has outlined the similarities between artificially restricted cerebral blood flow and the reduced blood flow associated with aging. Aiming to understand vascular dementia
First Multi-Cancer Blood Test Available Now
June 15, 2021
Biotech company GRAIL made history earlier this month when it introduced the first commercially available multi-cancer blood test. The test is based on analyzing tumor DNA in circulation and could
Rapamycin Improves How Our DNA Is Stored
June 11, 2021
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity
Calico Scientists Develop Safer Cellular Reprogramming
June 11, 2021
In a preprint paper, scientists from Calico, Google’s longevity research behemoth, suggest that contrary to our previous understanding, transient reprogramming of cells using Yamanaka factors involves suppressing cellular identity, which
Building Support for the War Against Aging
June 9, 2021
The life extension community has a number of long serving people in its ranks, and one of the longest-active of those in Russia is Mikhail Batin. His activities go way
COVID-19 Spike Protein Shown to Increase SASP
June 9, 2021
New research published in the journal Science has shown that the spike protein of SARS-CoV-2, the virus that causes COVID-19, causes senescent cells to secrete more of the senescence-associated secretory
Human Genome Fully Sequenced
June 8, 2021
In a preprint paper, scientists have announced the completion of the first full, telomere-to-telomere, sequencing of the human genome, more than two decades after the first draft of its sequencing.
The Two Kinds of p21 Expression
June 7, 2021
A team of researchers led by Dr. Judith Campisi of the Buck Institute has discovered valuable information about how cells express the senescence marker p21 [1]. Two genetic loci, one
Transcriptomic Aging Clock Measures More Than Just Age
June 3, 2021
Researchers have developed a new transcriptomic aging clock that incorporates information about biological pathways. With this approach, the clock predicts not only age but also how the state of various
Removing and Replacing Mitochondria in Human Cells
June 2, 2021
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering
Twin Study Shows That Diet and Exercise Lower Biological Age
June 1, 2021
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors – smoking, drinking, physical activity, and diet – affect biological age according to two biological age
Heavy Alcohol Use Linked to Greater Epigenetic Age in Women
May 31, 2021
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. A
Resilience as a New Measure of Biological Age
May 28, 2021
In a new paper published in Nature, a group of scientists led by Peter Fedichev explores human longevity through the concept of loss of resilience, by which the researchers mean
A Look at Idiopathic Pulmonary Fibrosis
June 21, 2021
A new review published in the American Journal of Respiratory Cell and Molecular Biology discusses the causes of, and potential treatments for, idiopathic pulmonary fibrosis (IPF). Fibrosis, but not focused on fibroblasts In the lungs, the trachea (airway) breaks out into a tree-like system of nodes.
The Aged Microenvironment Linked to Sarcopenia
June 17, 2021
Muscular degradation with age isn’t the result of a decline in the intrinsic regenerative ability of muscles, according to new research [1]. Instead, sarcopenia is likely due to changes in the muscle microenvironment that reduce repair and regeneration. Declining muscles Age-related muscle loss can begin as
Brain Blood Flow Restriction Resembles Brain Aging in Mice
June 16, 2021
A mouse study published in Aging Cell has outlined the similarities between artificially restricted cerebral blood flow and the reduced blood flow associated with aging. Aiming to understand vascular dementia Prior research has shown that reduced cerebral blood flow, known as hypoperfusion, results in vascular dementia
First Multi-Cancer Blood Test Available Now
June 15, 2021
Biotech company GRAIL made history earlier this month when it introduced the first commercially available multi-cancer blood test. The test is based on analyzing tumor DNA in circulation and could be a game-changer in the field of cancer diagnostics, especially if the company continues to improve
Rapamycin Improves How Our DNA Is Stored
June 11, 2021
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity [1]. This improvement to DNA storage has been observed in both fruit flies and mice in
Calico Scientists Develop Safer Cellular Reprogramming
June 11, 2021
In a preprint paper, scientists from Calico, Google’s longevity research behemoth, suggest that contrary to our previous understanding, transient reprogramming of cells using Yamanaka factors involves suppressing cellular identity, which may open the door to carcinogenic mutations. They also propose a milder reprogramming method inspired by
Building Support for the War Against Aging
June 9, 2021
The life extension community has a number of long serving people in its ranks, and one of the longest-active of those in Russia is Mikhail Batin. His activities go way back to 2008 when the non-profit organization Science for Life Extension Foundation, which was first created
COVID-19 Spike Protein Shown to Increase SASP
June 9, 2021
New research published in the journal Science has shown that the spike protein of SARS-CoV-2, the virus that causes COVID-19, causes senescent cells to secrete more of the senescence-associated secretory phenotype (SASP), causing hyperinflammation and weakening the body’s defenses against viruses. An established link The researchers
Human Genome Fully Sequenced
June 8, 2021
In a preprint paper, scientists have announced the completion of the first full, telomere-to-telomere, sequencing of the human genome, more than two decades after the first draft of its sequencing. This was made possible by new sequencing technologies [1]. Mind the gaps The human genome was
The Two Kinds of p21 Expression
June 7, 2021
A team of researchers led by Dr. Judith Campisi of the Buck Institute has discovered valuable information about how cells express the senescence marker p21 [1]. Two genetic loci, one protein Cellular senescence is partially determined by two cyclin-dependent kinase inhibitor proteins: p16 and p21. The
Transcriptomic Aging Clock Measures More Than Just Age
June 3, 2021
Researchers have developed a new transcriptomic aging clock that incorporates information about biological pathways. With this approach, the clock predicts not only age but also how the state of various genetic pathways changes with age, providing insight into the transcriptional changes involved in aging. Time for
Removing and Replacing Mitochondria in Human Cells
June 2, 2021
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Out with the old, in with the
Twin Study Shows That Diet and Exercise Lower Biological Age
June 1, 2021
Chinese scientists have performed a study on homozygous twins to determine how lifestyle factors – smoking, drinking, physical activity, and diet – affect biological age according to two biological age clocks. Their findings were a mixed bag, but they found evidence for eating lots of fruits
Heavy Alcohol Use Linked to Greater Epigenetic Age in Women
May 31, 2021
A study funded by the National Institutes of Health has found that excessive alcohol consumption increases the epigenetic age of non-Hispanic White women according to the GrimAge epigenetic clock. A large study with a few conclusive results This study, the first of its kind to show
Resilience as a New Measure of Biological Age
May 28, 2021
In a new paper published in Nature, a group of scientists led by Peter Fedichev explores human longevity through the concept of loss of resilience, by which the researchers mean the gradual age-related expansion of time that the body needs to recover from stress, such as