July 23, 2024
Scientists have developed a conjugate of a drug and a nucleus-targeting antibody that can attack multiple types of cancer cells without targeting a particular antigen [1]. The anti-nuclear missile Antinuclear antibodies (ANA) are usually associated with autoimmune diseases, such as lupus, where those antibodies attack cellular nuclei, binding to nucleic acids and other local molecules....
August 24, 2022
In a new review published in Clinica Chimica Acta, researchers from the University of Zagreb discuss immunoglobulin G glycans, the changes that their composition undergoes with aging, and their potential as biomarkers of aging [1]. Glycans are not AGEs One of the review's co-authors is Prof. Gordan Lauc, who gave a presentation on the importance...
October 19, 2021
A group of researchers has developed a delivery system that identifies senescent cells and injects them with a deadly compound. This offers a potential solution to the problem of targeted delivery of senolytics [1]. Cellular senescence has been implicated in numerous aging-related disorders, including fibrosis, diabetes, cancer, and Alzheimer's. Today, senolytics, drugs that remove senescent...
March 22, 2021
Until now, it was unclear as to whether drugs that clear amyloid, which accumulate in the brain during aging and accompany diseases such as Alzheimer's, have any influence over cognitive decline. Previous studies have aimed to find this out, but results have been inconclusive due to study designs, hard-to-interpret data, and other issues that muddy...
June 07, 2018
Researchers at the University of California San Diego School of Medicine have shown that they can block inflammation in mice, thereby protecting them from liver disease and hardening of the arteries while increasing their healthy lifespan. The study, published in the journal Nature, shows that inflammation can be blocked using a naturally occurring antibody that...