Tag: Clock

A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different...

A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to...

A recent review discusses the development of biological aging clocks, their capabilities and limitations, the discoveries they enabled, and possible future developments in this area [1]. How do we measure aging? Developments in science and technology have allowed researchers to move beyond speculation and philosophical debates about aging to study its molecular underpinnings and the...

A perspective published in Aging and Disease has recommended the use of underground laboratory space in order to remove the effects of surface radiation on biological clocks. A question of entropy The cascading failure of bodily systems, leading to the loss of organ function, sits downstream of fundamental damage to genomics and epigenomics. However, how...

A new study has used aging trajectories of various cell types to predict diseases such as Alzheimer’s and lung cancer [1]. This expands on previous research into organ-specific aging. Age is more than one number Gone are the days when aging was assumed to be happening uniformly across every tissue at once. Today, we know...

A new study links accelerated aging to early-onset solid cancers, while showing that this gap is becoming wider with each new generation [1]. Why do more young people get cancer? While life expectancy has been on the rise for decades (though it has slowed in recent years), counterintuitively, early-onset cancer is becoming more common. Cancers...