October 26, 2021
Two of the most prominent experts in the field have published a review of cellular senescence in the context of metabolism, and we bring you the highlights [1]. We rarely cover review papers, but when Cristopher D. Wiley and Judith Campisi, two of the most prominent experts on senescent cells, publish a review on senescence...
April 08, 2021
A lipid metabolite could serve as a novel biomarker to test the performance of senolytics, according to a new study [1]. Such a biomarker can be detected from blood or urine, allowing for non-invasive testing, and experiments have shown that it plays a functional role in cellular senescence. Slowing down to stay safe Cellular senescence...
September 18, 2019
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent. Senescence is primarily caused by telomere shortening and DNA damage, and senescent cells are known to contribute to multiple diseases, such as Alzheimer's, Parkinson's,...
May 03, 2019
Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging. Senescent cells and the SASP As we get older, an increasing number of our cells enter into a state known as senescence. They cease dividing and...
April 03, 2019
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without age-related diseases. Dr. Judith Campisi, one of the speakers at this conference, is a...
April 01, 2019
Last Wednesday, I landed in Berlin, Germany at around 12:30. About an hour later, I was briefly in Cafè Alex, right next to the tapering TV Tower, where I met some of my colleagues from LEAF—some of whom I had never seen in person before—as well as other volunteers and members of HEALES, our friend...