Tag: ApoE4

The pro-Alzheimer's allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer's disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for the common, late-onset form of...

According to a new study, as many as 90% of Alzheimer’s cases can be attributed to “suboptimal” variants of the APOE gene. These results highlight the gene’s importance for Alzheimer’s prevention [1]. Three alleles of APOE A growing amount of research links Alzheimer’s disease to the gene APOE, which codes for apolipoprotein E [2]. This...

In Aging Cell, researchers have outlined the relationship between Alzheimer's, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer's disease, such as cognitive decline and brain deterioration, are very well-known [1]. However, other symptoms, such as pain sensitivity, may precede these key manifestations, providing an early...

Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Microplastics and the brain Exposure to tiny particles that plastic products shed (microplastics) has been linked to increased mortality and diseases [2]. Microplastics are ubiquitous and enter...

A new study suggests that the gene variant APOE4 promotes Alzheimer’s disease by increasing gliosis, but this effect can be blocked by inhibiting the protein HMGB1 [1]. The dreaded E4 While scientists still do not know the precise causes of Alzheimer’s disease or how to treat it, a person's APOE gene variant is highly predictive...

Researchers publishing in Alzheimer's and Dementia have published a correlation between the Alzheimer's-linked protein tau and another protein, bisecting N-acetylglucosamine (GlcNAc), which suggests its usefulness as a biomarker. The need for early prediction This paper begins with a note that to be effective, Alzheimer's treatment must begin before irrevocable neurodegeneration has already occurred [1]. Therefore,...