Tag: Cancer

A new study links accelerated aging to early-onset solid cancers, while showing that this gap is becoming wider with each new generation [1]. Why do more young people get cancer? While life expectancy has been on the rise for decades (though it has slowed in recent years), counterintuitively, early-onset cancer is becoming more common. Cancers...

Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. This can inform future early-stage cancer therapies [1]. Cancer is a disease of aging. With the exception of childhood cancers, most of which stem from inherited genetic errors, adult cancers tend to occur later in life....

Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assassination of cells CRISPR-based systems work by cutting or changing DNA at a particular spot, an ability that can be used to fix dangerous mutations, such as in the...

Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune system Modern cancer immunotherapies only work for a minority of patients. The reason, broadly, is that many tumors are immunologically “cold”: they do not trigger, and/or actively suppress, the...

Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study [1]. How to get immune cells into the tumor? One of the central challenges in cancer immunotherapy is getting the right immune cells to the right place. Natural killer (NK) cells...

In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach. It showed higher efficacy across three cancer types, including a solid tumor [1]. CAR T therapies: promising but imperfect Ideally, T cells, the killer cells of our adaptive immune systems, should...