Tag: Cellular Senescence

Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux by targeting a key molecule, transcription factor EB (TFEB), alleviates some of this damage. An acute disease with lasting effects AKI is a rapidly developing condition that causes...

Researchers have described a method of using exosomes derived from mesenchymal stem cells (MSCs) to fight harmful metabolic changes in the liver. Another look at exosomes This is far from the first attempt at using MSC-derived exosomes, particularly exosomes derived from MSCs originally taken from human umbilical cord tissue (HucMDEs derived from HucMSCs), to treat...

Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs) do not themselves produce proteins, they serve crucial regulatory functions. Short ncRNAs, such as microRNAs, are involved in the fine-tuning of transcriptional pathways, modulating the proteins produced by coding...

Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets sticky As part of the transcription process that produces necessary proteins, RNA must chemically interact with DNA. When it binds to DNA and integrates itself into the genome, it...

In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering mTOR signaling. Senescent cells don't sense nutrients properly Deregulated Nutrient SensingThe four pathways of nutrient-sensing regulate metabolism and influence aging. The four associated key protein groups are IGF-1, mTOR, sirtuins, and AMPK. We call these proteins “nutrient-sensing”...

A team of reviewers has taken a look at the relationship between cancer, cellular senescence, and vascular overgrowth and published this information in Aging Cell. Different gut cancers form through different pathways The authors begin their paper by discussing two cancers that are downstream of inflammatory bowel disease (IBD): colorectal cancer (CRC) [1] and colitis-associated...