Tag: SIRT1

A team of researchers has written a paper with a surprising finding: that many of the benefits of caloric restriction and increased NAD+ may be due to their effects on the cilia of hypothalamic neurons. Neuronal cilia have a relationship to overall health Nicotinamide Adenine Dinucleotide (NAD): Benefits and ResearchNicotinamide adenine dinucleotide (NAD) is a...

Reviewers publishing in Biology have elucidated SIRT1 functional reserve as an aspect of aging, describing how its depletion is an upstream cause of age-related disorders at the cellular level and explaining why many prospective therapies that increase SIRT1 and NAD+ have not had promising results. Managing a dangerous byproduct Reactive oxygen species (ROS) are necessarily...

Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. When DNA modifies itself Long interspersed elements-1 (LINE-1) have existed in organisms' genomes, including our own, for well over a billion years [1]. They are the only autonomous elements...

Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1]. From ancient times to contemporary therapies Hallucinogenic mushrooms have a long history of use, reaching back to ancient times when people often used them for...

Researchers publishing in Nature Communications have found that nicotinamide riboside (NR) improves walking distance for people who have peripheral artery disease (PAD) in the legs. When the arms and legs don't get enough blood Ischemia, the failure of blood vessels to deliver sufficient oxygen and nutrients, is a key part of fatal conditions such as...

A recent paper has investigated the impact of polystyrene nanoplastics on the molecular processes of male reproductive tissues in mice [1]. Health risks of micro- and nanoplastics Microplastic and nanoplastic contamination is a worldwide public health concern for a good reason. Numerous research papers have associated microplastics with multiple health risks in the respiratory, immune,...