Category: Biology of Aging
A Gene That Changes Function With Aging in Mice
December 18, 2025
In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We
Analyzing the Quality of Preclinical Anti-Aging Research
December 17, 2025
Researchers have investigated the reporting quality of preclinical studies’ outcomes in anti-aging research. They analyzed how study quality changed over time, shortcomings in research, and the improvements that can be
Senescence Exacerbated by Mitochondrial RNA Leakage
December 16, 2025
Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. The
Targeting a Metabolic Regulator Reduces Fat in Mice
December 15, 2025
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around
Molecule From Chocolate Linked to Slower Epigenetic Aging
December 12, 2025
A new observational study spanning two human cohorts has found a link between theobromine, a phytochemical abundant in cocoa, and slower epigenetic aging [1]. A yummy geroprotector? Popular wisdom has
Human Umbilical Cord Blood Metabolites Lengthen Worms’ Lives
December 11, 2025
Comparison of human umbilical cord blood with adult plasma revealed hundreds of metabolites whose abundances were age-dependent. Two different formulas, each a mix of a few metabolites, demonstrated anti-senescence properties
A Key Molecular Link Between Aging and Osteoporosis
December 11, 2025
In Aging Cell, researchers have described how an age-related deficiency in another compound leads the antioxidant FoxO1 to contribute to bone deterioration in osteoporosis by siphoning from a bone-building pathway.
Stem Cell-Derived Vesicles Improve Cognition in Aged Monkeys
December 9, 2025
In a new study, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) improved spatial working memory in rhesus macaques, suggesting a possible reversal of age-related cognitive decline [1]. The
Nasal Tissue Extracellular Vesicles Improve Health in Mice
December 8, 2025
Researchers have discovered that extracellular vesicles (EVs) derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain. A very regenerative tissue Previous work
Microglia Replacement Already Working in Humans
December 5, 2025
A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in just five years [1]. Repair
Engineering Immune Cells to Fight Gut Senescence
December 4, 2025
In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the gut lining ages Of
Second-Hand Smoke Alters Protein Expression
December 3, 2025
A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes, including immune, inflammatory, and tissue repair pathways [1]. Carrying the
A Subtype of T Cells Counters Senescence in Mice
November 28, 2025
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy
The Roles of Phenylalanine and Tyrosine in Lifespan
November 26, 2025
A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with
Fixing Lysosomes Improves Blood Stem Cell Function
November 25, 2025
In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few
A Gene That Changes Function With Aging in Mice
December 18, 2025
In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We have recently reported on a potential treatment for visceral fat, as this kind of fat is
Analyzing the Quality of Preclinical Anti-Aging Research
December 17, 2025
Researchers have investigated the reporting quality of preclinical studies’ outcomes in anti-aging research. They analyzed how study quality changed over time, shortcomings in research, and the improvements that can be made in the future in order to yield as many valuable insights as possible [1]. The
Senescence Exacerbated by Mitochondrial RNA Leakage
December 16, 2025
Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. The new target The increasing abundance of senescent cells with age has been linked to numerous diseases
Targeting a Metabolic Regulator Reduces Fat in Mice
December 15, 2025
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous fat. While this kind of fat is obviously not healthy to have
Molecule From Chocolate Linked to Slower Epigenetic Aging
December 12, 2025
A new observational study spanning two human cohorts has found a link between theobromine, a phytochemical abundant in cocoa, and slower epigenetic aging [1]. A yummy geroprotector? Popular wisdom has it that not many things in life are both healthy and delicious, but according to research,
Human Umbilical Cord Blood Metabolites Lengthen Worms’ Lives
December 11, 2025
Comparison of human umbilical cord blood with adult plasma revealed hundreds of metabolites whose abundances were age-dependent. Two different formulas, each a mix of a few metabolites, demonstrated anti-senescence properties in cell cultures and model organisms [1]. Young blood has benefits Previous research has provided evidence
A Key Molecular Link Between Aging and Osteoporosis
December 11, 2025
In Aging Cell, researchers have described how an age-related deficiency in another compound leads the antioxidant FoxO1 to contribute to bone deterioration in osteoporosis by siphoning from a bone-building pathway. A harmful antioxidant? Because they fight against harmful reactive oxygen species (ROS), antioxidants, both external and
Stem Cell-Derived Vesicles Improve Cognition in Aged Monkeys
December 9, 2025
In a new study, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) improved spatial working memory in rhesus macaques, suggesting a possible reversal of age-related cognitive decline [1]. The “normal” decline Even “healthy” aging (not accompanied by obvious age-related diseases such as dementia) leads to
Nasal Tissue Extracellular Vesicles Improve Health in Mice
December 8, 2025
Researchers have discovered that extracellular vesicles (EVs) derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain. A very regenerative tissue Previous work involving the transection of sizable portions of the nasal mucosa has found that this tissue grows
Microglia Replacement Already Working in Humans
December 5, 2025
A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in just five years [1]. Repair or replace Microglia, the resident immune cells of the brain, have been implicated in various diseases,
Engineering Immune Cells to Fight Gut Senescence
December 4, 2025
In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the gut lining ages Of all the tissues in the human body, the intestinal epithelium, which lines the gut, replaces its
Second-Hand Smoke Alters Protein Expression
December 3, 2025
A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes, including immune, inflammatory, and tissue repair pathways [1]. Carrying the consequences of something you didn’t do It is widely known and researched that smoking is bad
A Subtype of T Cells Counters Senescence in Mice
November 28, 2025
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy but also suggests that an immune system can be “overly youthful.” When generals become fighters CD4
The Roles of Phenylalanine and Tyrosine in Lifespan
November 26, 2025
A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with sex-specific differences. The results for phenylalanine were more inconsistent [1]. One by one Model animal research
Fixing Lysosomes Improves Blood Stem Cell Function
November 25, 2025
In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few and far between Hematopoietic stem cells (HSCs) are rare and precious: they produce blood progenitor cells,