Category: News
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your
What is Nicotinamide Riboside? A Summary of NR
September 27, 2021
Nicotinamide riboside (NR) is part of the B3 vitamin family. Like other forms of vitamin B3, nicotinamide riboside gets converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for life.
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause
Epigenomic Rejuvenation for Restoring Bone Stem Cells
September 17, 2021
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow
Understanding How We Evolved to Age
September 16, 2021
In a paper in Frontiers in Genetics, Maël Lemoine of France’s CNRS offers an evolutionary perspective on the hallmarks of aging [1]. This review examines the appearance of the hallmarks
MoveAge: A New Movement-Based Biological Aging Clock
September 14, 2021
Researchers have developed a biological aging clock based on movement data from wearable devices. Using their clock and the same dataset, they identified a few possibly life-prolonging nutrients and drugs
Key Source of Thymic Aging Discovered
September 13, 2021
Publishing in Nature Communications’ Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. The thymus and its involution
BioNTech mRNA Cancer Treatment Enters Human Trials
September 10, 2021
The current pandemic has brought mRNA vaccines into the spotlight and have likely sped up the widespread adoption and usage of this technology. Now, a company has its sights set
Boosting NANOG to Revitalize Muscle Cell Progenitors
September 9, 2021
Boosting the expression of the transcription factor NANOG reduces markers of cellular senescence in cultured muscle cells and in live mouse models, according to new research [1]. This holds out
MTOR Inhibition Leads to 30% Life Extension in Progeric Mice
September 8, 2021
Researchers have created a new mouse model for studying Hutchinson-Gilford progeria syndrome (HGPS) and achieved 30% lifespan extension in these animals by genetically downregulating mTOR [1]. HGPS: accelerated aging HGPS,
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that mortality risk plateaus past 110 For many years now, just how long a human being can
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and a common
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your biological age Physical activity (PA) and healthy diet are two powerful interventions that have time and
What is Nicotinamide Riboside? A Summary of NR
September 27, 2021
Nicotinamide riboside (NR) is part of the B3 vitamin family. Like other forms of vitamin B3, nicotinamide riboside gets converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for life. For this reason, it is often called a NAD+ precursor because it is part of the
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain and spine. A detailed, metabolic analysis The researchers extracted CSF from 41 people aged 20 to
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new research [1]. Proofreading proteins The loss of proteostasis is one of the hallmarks of aging. However,
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing clocks that measure biological age. We talked with Dr. Levine about her work, the impact that
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were
Epigenomic Rejuvenation for Restoring Bone Stem Cells
September 17, 2021
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow stem cells rejuvenated. Bones become weaker as we age as stem cell function declines With advancing
Understanding How We Evolved to Age
September 16, 2021
In a paper in Frontiers in Genetics, Maël Lemoine of France’s CNRS offers an evolutionary perspective on the hallmarks of aging [1]. This review examines the appearance of the hallmarks in different groups across the tree of life, with the aim of providing a comprehensive picture
MoveAge: A New Movement-Based Biological Aging Clock
September 14, 2021
Researchers have developed a biological aging clock based on movement data from wearable devices. Using their clock and the same dataset, they identified a few possibly life-prolonging nutrients and drugs [1]. I move, therefore I am Developing reliable biomarkers of aging is crucial for geroscience, since
Key Source of Thymic Aging Discovered
September 13, 2021
Publishing in Nature Communications’ Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. The thymus and its involution The thymus is a boot camp for T cells. Originating from bone marrow, T (for thymus)
BioNTech mRNA Cancer Treatment Enters Human Trials
September 10, 2021
The current pandemic has brought mRNA vaccines into the spotlight and have likely sped up the widespread adoption and usage of this technology. Now, a company has its sights set on treating cancer with mRNA technology, and the initial animal data is positive. mRNA steps up
Boosting NANOG to Revitalize Muscle Cell Progenitors
September 9, 2021
Boosting the expression of the transcription factor NANOG reduces markers of cellular senescence in cultured muscle cells and in live mouse models, according to new research [1]. This holds out the hope that cells could be rejuvenated without reprogramming them to pluripotency, avoiding some of the
MTOR Inhibition Leads to 30% Life Extension in Progeric Mice
September 8, 2021
Researchers have created a new mouse model for studying Hutchinson-Gilford progeria syndrome (HGPS) and achieved 30% lifespan extension in these animals by genetically downregulating mTOR [1]. HGPS: accelerated aging HGPS, sometimes referred to just as ‘progeria’, is a rare disease that affects one in 4 to