Category: News
Disappointing News for UNITY Biotech
August 18, 2020
While we enjoy reporting positive news, we do occasionally have to report bad news, and today is one of those days. There has been some disappointing news from UNITY Biotechnology
IGF-1 Reverses Mitochondrial Decline in Smooth Muscular Cells
August 18, 2020
Scientists have shown that insulin-like growth factor (IGF-1) mitigates age-related mitochondrial decline and cellular aging in cultured smooth muscular cells [1], although other studies paint a grimmer picture of IGF-1’s
Researchers Rejuvenate the Thymi of Old Mice
August 17, 2020
Researchers have successfully demonstrated that rejuvenation of the aged thymus to make it functionally younger again is possible. The thymus wastes away as we age The thymus is a small
Systemic Reduction of Cdc42 Activity Increases Lifespan
August 14, 2020
A novel treatment that inhibits the activity of the Cdc42 protein has been found to extend the lifespan of aged mice, most likely through epigenetic changes and regulation of inflammatory
Towards a Telomerase Gene Therapy for Pulmonary Fibrosis
August 12, 2020
Back in January 2018, researchers at CNIO reversed lung fibrosis in mice using a single gene therapy. Today, we want to spotlight a new study that builds on the positive
Major Circadian Cycle Regulator Improves Chromatin Stability
August 11, 2020
Researchers have found that CLOCK, a protein that regulates the circadian cycle of our cells, also fights cellular senescence by promoting chromatin stability [1]. Since its very beginning, life on
Reviewing Epigenetic Alterations as a Cause of Aging
August 10, 2020
Epigenetic alterations, which are one of the proposed reasons we age, are the changes to gene expression that our cells experience as we get older. These alterations harm the fundamental
New Startup SENISCA Aims to Reset Senescent Cells
August 7, 2020
Senescent cells accumulate in our bodies as we age, increasing inflammation and raising our risk of suffering from cancer and other age-related diseases. A new biotech startup plans to reset
Astrocytes Become Neural Stem Cells After Injury
August 6, 2020
A new study published in Cell Stem Cell has shown how astrocytes, glial cells that perform multiple critical functions in the brain, can become neural stem cells (NSCs) in response
Caloric Restriction Appears to Improve Stem Cell Function
August 5, 2020
Researchers have taken a look at how caloric restriction seems to improve intestinal stem cell function in a new open-access study. Inflammaging is a precursor of age-related diseases The lining
Reducing Cognitive Decline in Mice with Alzheimer’s
August 4, 2020
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer’s disease (AD), in the brains of mice. They propose
Rejuvenation Roundup July 2020
August 3, 2020
This is our last monthly roundup before Ending Age-Related Diseases 2020, our first fully online conference, and plenty of rejuvenation research has been conducted this month. Let’s take a look
Glucosamine Linked to Reduced All-Cause Mortality
July 31, 2020
It is one of the most commonly used supplements frequently taken to address joint pain, but there might be more to this dietary supplement than first meets the eye. Glucosamine
Senescent Cell Death Promotes Aging Resistance
July 30, 2020
The well-known resistance of naked mole rats to aging and aging-related effects is due at least in part to an unusual ability to clear away senescent cells. This suggests that
The “Love Hormone” Oxytocin as an Alzheimer’s Therapy
July 29, 2020
Japanese researchers led by Professor Akiyoshi Saitoh from the Tokyo University of Science have published new research that explores the potential of oxytocin as a therapy to combat cognitive disorders
Disappointing News for UNITY Biotech
August 18, 2020
While we enjoy reporting positive news, we do occasionally have to report bad news, and today is one of those days. There has been some disappointing news from UNITY Biotechnology with the release of its Phase 2 senolytic trial of its candidate drug UBX0101. SOUTH SAN
IGF-1 Reverses Mitochondrial Decline in Smooth Muscular Cells
August 18, 2020
Scientists have shown that insulin-like growth factor (IGF-1) mitigates age-related mitochondrial decline and cellular aging in cultured smooth muscular cells [1], although other studies paint a grimmer picture of IGF-1’s effects. Mitochondrial decline and aging Mitochondria, dubbed “the powerhouses of the cell” for producing the bulk
Researchers Rejuvenate the Thymi of Old Mice
August 17, 2020
Researchers have successfully demonstrated that rejuvenation of the aged thymus to make it functionally younger again is possible. The thymus wastes away as we age The thymus is a small organ located in the upper part of the chest directly behind the sternum and between the
Systemic Reduction of Cdc42 Activity Increases Lifespan
August 14, 2020
A novel treatment that inhibits the activity of the Cdc42 protein has been found to extend the lifespan of aged mice, most likely through epigenetic changes and regulation of inflammatory cytokines. Cdc42 is linked with lifespan Cdc42 is a RhoGTPase, a kind of signaling protein involved
Towards a Telomerase Gene Therapy for Pulmonary Fibrosis
August 12, 2020
Back in January 2018, researchers at CNIO reversed lung fibrosis in mice using a single gene therapy. Today, we want to spotlight a new study that builds on the positive results of the 2018 research, taking us another step closer to telomerase gene therapy in humans
Major Circadian Cycle Regulator Improves Chromatin Stability
August 11, 2020
Researchers have found that CLOCK, a protein that regulates the circadian cycle of our cells, also fights cellular senescence by promoting chromatin stability [1]. Since its very beginning, life on Earth had to adapt to our planet’s natural 24-hour rotation cycle. Rising to the challenge, nature
Reviewing Epigenetic Alterations as a Cause of Aging
August 10, 2020
Epigenetic alterations, which are one of the proposed reasons we age, are the changes to gene expression that our cells experience as we get older. These alterations harm the fundamental functions of our cells and can increase the risk of cancer and other age-related diseases. Depending
New Startup SENISCA Aims to Reset Senescent Cells
August 7, 2020
Senescent cells accumulate in our bodies as we age, increasing inflammation and raising our risk of suffering from cancer and other age-related diseases. A new biotech startup plans to reset aged senescent cells to a youthful state to deal with this problem. The rejuvenation biotechnology field
Astrocytes Become Neural Stem Cells After Injury
August 6, 2020
A new study published in Cell Stem Cell has shown how astrocytes, glial cells that perform multiple critical functions in the brain, can become neural stem cells (NSCs) in response to injury. Astrocytes’ normal functions The term ‘astrocyte’, meaning star-shaped cell, refers to a very heterogenous
Caloric Restriction Appears to Improve Stem Cell Function
August 5, 2020
Researchers have taken a look at how caloric restriction seems to improve intestinal stem cell function in a new open-access study. Inflammaging is a precursor of age-related diseases The lining of the intestines helps to prevent the entry of microbes and unwanted molecules into the bloodstream
Reducing Cognitive Decline in Mice with Alzheimer’s
August 4, 2020
A group of scientists have shown that the SIRT2 protein increases the accumulation of amyloid beta, a known marker of Alzheimer’s disease (AD), in the brains of mice. They propose a mechanism underlying this phenomenon and demonstrate that inhibiting SIRT2 ameliorates AD-associated cognitive decline in mice
Rejuvenation Roundup July 2020
August 3, 2020
This is our last monthly roundup before Ending Age-Related Diseases 2020, our first fully online conference, and plenty of rejuvenation research has been conducted this month. Let’s take a look at what’s happened in July. LEAF News Ending Age-Related Diseases 2020 July Update: Our annual conference,
Glucosamine Linked to Reduced All-Cause Mortality
July 31, 2020
It is one of the most commonly used supplements frequently taken to address joint pain, but there might be more to this dietary supplement than first meets the eye. Glucosamine was originally discovered during the 1960s in Italy by pharmacologist Professor Luigi Rovati. Glucosamine is one
Senescent Cell Death Promotes Aging Resistance
July 30, 2020
The well-known resistance of naked mole rats to aging and aging-related effects is due at least in part to an unusual ability to clear away senescent cells. This suggests that senolytic drugs, which aim to do the same in humans, may prove a fruitful path to
The “Love Hormone” Oxytocin as an Alzheimer’s Therapy
July 29, 2020
Japanese researchers led by Professor Akiyoshi Saitoh from the Tokyo University of Science have published new research that explores the potential of oxytocin as a therapy to combat cognitive disorders such as Alzheimer’s disease. Oxytocin is often called the love hormone, given its role in the