Category: News
Metformin Enhances Autophagy and Alleviates Inflammaging
May 14, 2020
A recent study published in Cell Metabolism has shown that metformin, a drug that has been previously shown to be effective against some aspects of aging, ameliorates inflammaging by promoting
Resistance Training in Middle Age Doubles Muscle NAD+ Levels
May 13, 2020
A new study suggests that we can actively fight back against age-related decline with resistance training to restore our levels of NAD+, a critical molecule used by the mitochondria in
A Senolytic Prodrug For Multiple Cell Types
May 12, 2020
A group of scientists from China has successfully created an effective senolytic prodrug that targets the enzyme β-galactosidase [1]. This prodrug, called SSK1, has demonstrated impressive results across various cell
Blood Factors Reverse Epigenetic Age by Half in Rats
May 11, 2020
Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood. Epigenetic changes One of the proposed reasons we age are the
The Challenge of Including Aging in the ICD
May 8, 2020
Few things in aging research are ever straightforward, and today’s topic is no exception, as two researchers enjoy some back and forth regarding whether and how the World Health Organization
The Moonshot Venture Fellowship
May 6, 2020
We had the opportunity to speak to Apollo Health Ventures about the Moonshot Venture Fellowship and about the aging research field in general from the perspective of a venture capital
The Paper That Helped Change WHO’s Position on Aging
May 5, 2020
We had the opportunity to interview Daria Khaltourina about a review written by her team, which recommended giving aging its own disease classification in the ICD-11. Back in 2018, an
Modulating Macrophages to Prevent Disc Degeneration
May 4, 2020
A paper published in Aging has shown that it is possible to treat spinal disc degeneration through altering the epigenetics of macrophages. Macrophages and inflammaging Macrophages are the clean-up crew
Rejuvenation Roundup April 2020
May 1, 2020
As the COVID-19 pandemic rages on throughout the world, so does aging – and the two of them are heavily connected. Fortunately, research into dealing with both continues apace. Here’s
Senolytics Could Cause a Sea Change in How We Treat Aging
April 30, 2020
Today, we want to highlight a new review that takes a look at senescent cell removal therapies and their potential to treat and reverse age-related diseases by reversing one of
NMN Restores Brain Function In Old Mice
April 28, 2020
A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major
Restoring Telomerase Activity in Telomere Biology Diseases
April 27, 2020
Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres. Telomeres
Refining Senolytic Drugs to Be Less Toxic and More Effective
April 24, 2020
Researchers have developed a way to modify an existing cancer drug with toxic side effects into something that is less toxic to blood platelets and more effective at removing harmful
Fibroblasts Reprogrammed Into Photoreceptors Restore Vision
April 21, 2020
A group of researchers has succeeded in directly reprogramming fibroblast cells into photoreceptors and transplanting them into mice, which resulted in partial restoration of vision [1]. This achievement can potentially
Inflammaging Links Alzheimer’s and Changes to the Microbiome
April 20, 2020
A new review sheds light on the connection between chronic age-related inflammation, modern lifestyles, and the development of Alzheimer’s disease. Inflammaging is the link between the microbiome, aging, and Alzheimer’s
Metformin Enhances Autophagy and Alleviates Inflammaging
May 14, 2020
A recent study published in Cell Metabolism has shown that metformin, a drug that has been previously shown to be effective against some aspects of aging, ameliorates inflammaging by promoting autophagy, the cellular recycling of damaged components. Mitochondrial dysfunction, autophagy, and TH17 Mitochondrial dysfunction is one
Resistance Training in Middle Age Doubles Muscle NAD+ Levels
May 13, 2020
A new study suggests that we can actively fight back against age-related decline with resistance training to restore our levels of NAD+, a critical molecule used by the mitochondria in our cells to produce energy. NAD+ and mitochondria The mitochondria are the powerhouses of the cell,
A Senolytic Prodrug For Multiple Cell Types
May 12, 2020
A group of scientists from China has successfully created an effective senolytic prodrug that targets the enzyme β-galactosidase [1]. This prodrug, called SSK1, has demonstrated impressive results across various cell types and advantages over some existing senolytics. Cellular senescence is a phenomenon in which cells stop
Blood Factors Reverse Epigenetic Age by Half in Rats
May 11, 2020
Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood. Epigenetic changes One of the proposed reasons we age are the changes to gene expression that our cells experience as we get older; these are commonly called
The Challenge of Including Aging in the ICD
May 8, 2020
Few things in aging research are ever straightforward, and today’s topic is no exception, as two researchers enjoy some back and forth regarding whether and how the World Health Organization (WHO) should recognize the aging processes as a disease. Proposing a new framework to facilitate development
The Moonshot Venture Fellowship
May 6, 2020
We had the opportunity to speak to Apollo Health Ventures about the Moonshot Venture Fellowship and about the aging research field in general from the perspective of a venture capital firm. Apollo Health Ventures is a life science venture capital firm and life science company builder
The Paper That Helped Change WHO’s Position on Aging
May 5, 2020
We had the opportunity to interview Daria Khaltourina about a review written by her team, which recommended giving aging its own disease classification in the ICD-11. Back in 2018, an international group of scientists filed a proposal with the World Health Organization to introduce aging as
Modulating Macrophages to Prevent Disc Degeneration
May 4, 2020
A paper published in Aging has shown that it is possible to treat spinal disc degeneration through altering the epigenetics of macrophages. Macrophages and inflammaging Macrophages are the clean-up crew of the immune system, engulfing and destroying harmful germs, but their polarization is a double-edged sword.
Rejuvenation Roundup April 2020
May 1, 2020
As the COVID-19 pandemic rages on throughout the world, so does aging – and the two of them are heavily connected. Fortunately, research into dealing with both continues apace. Here’s what happened in the world of rejuvenation biotechnology in April. LEAF News Ending Age-Related Diseases 2020
Senolytics Could Cause a Sea Change in How We Treat Aging
April 30, 2020
Today, we want to highlight a new review that takes a look at senescent cell removal therapies and their potential to treat and reverse age-related diseases by reversing one of the aging processes. The current approach of medicine to treating age-related disease is broken The current
NMN Restores Brain Function In Old Mice
April 28, 2020
A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities
Restoring Telomerase Activity in Telomere Biology Diseases
April 27, 2020
Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres. Telomeres and telomerase Each chromosome that stores our genetic information has a protective cap at each end
Refining Senolytic Drugs to Be Less Toxic and More Effective
April 24, 2020
Researchers have developed a way to modify an existing cancer drug with toxic side effects into something that is less toxic to blood platelets and more effective at removing harmful and inflammatory senescent cells, one of the reasons we age, from mice. What are senescent cells?
Fibroblasts Reprogrammed Into Photoreceptors Restore Vision
April 21, 2020
A group of researchers has succeeded in directly reprogramming fibroblast cells into photoreceptors and transplanting them into mice, which resulted in partial restoration of vision [1]. This achievement can potentially lead to the development of cheap and effective treatments for retinopathies such as age-related macular degeneration
Inflammaging Links Alzheimer’s and Changes to the Microbiome
April 20, 2020
A new review sheds light on the connection between chronic age-related inflammation, modern lifestyles, and the development of Alzheimer’s disease. Inflammaging is the link between the microbiome, aging, and Alzheimer’s disease Aging is accompanied by a chronic, smoldering background of inflammation known as inflammaging. This backdrop