Category: News
Natural Senotherapeutics that Mimic Dasatinib
March 27, 2024
Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1].
First Transplantation of a Pig Kidney into a Human
March 26, 2024
After a total of 69 rejection-preventing gene edits, history has been made with the first-ever successful transplantation of a pig kidney into a human patient. Xenotransplantation within reach Organ transplantation
An Experimental Brain Protector May Fight Obesity
March 25, 2024
According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed
Glial Cells and Neurons Mutate Differently
March 24, 2024
In Cell, researchers have published a paper outlining the different ways in which brain cells slowly mutate with aging. The genomic damage of aging Cells accumulate mutations with aging, including
David Sinclair Hopes Rejuvenation Possible in a Few Decades
March 22, 2024
In this new interview, David Sinclair, Harvard professor and the author of “Lifespan”, explains his theory of aging, shares parts of his health routine, and reveals which directions in today’s
Epigenetic Memory Might Underlie Multiple Sclerosis
March 21, 2024
In an in-depth paper in Nature, researchers have explained how astrocytes, helper cells that provide crucial brain functions, epigenetically remember things in a way that encourages inflammation. Traumatized cells Long-lived
Springtime and a Time for Growth in the Rejuvenation Field
March 21, 2024
Spring is in the air if you are in the Northern Hemisphere, and in the theme of new growth, let’s see what the lifespan.io team has been up to recently.
Caloric Restriction in Primates Leads to Gut Changes
March 20, 2024
In a recent Nature Communications paper, the researchers investigated changes in weight, metabolism, and microbiome that resulted from periodic restricted feeding in non-human primates [1]. Continuous vs. time-restricted caloric restriction
Journal Club Episode 2 – 2024
March 20, 2024
The Journal Club returns to the lifespan.io Facebook page with Dr. Oliver Medvedik as your host on Friday, March 22nd at 12:00 Eastern time. This new paper further explores the
How to Test One Million Molecules
March 19, 2024
Ora Biomedical has created a robot for high-throughput screening of life-extending compounds in worms, and you can buy an experiment for 100 dollars. Things in the longevity field look bright
A Small Molecule to Restore the Liver
March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn’t
Study Suggests 14 Existing Drugs Increase Human Lifespan
March 15, 2024
Scientists have used a huge database to find links between existing drugs and human lifespan. Only 14 of more than 400 showed a positive correlation [1]. Reinventing the wheel? One
Controlling a Protein to Stop Obesity
March 14, 2024
In GeroScience, researchers have described how turning off a specific protein prevents mice from getting obese in old age. Mimicking hypoxia Hypoxia-inducible factors (HIFs) are a collection of three proteins
InSilico Shares Details on AI-Generated Drug Candidate
March 14, 2024
In a new paper, InSilico has reported on its impressive success with a drug against idiopathic pulmonary fibrosis that was created by AI “from A to Z” and is currently
Senolytic Activity of Drug-Polyphenol Combinations
March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Various drugs
Natural Senotherapeutics that Mimic Dasatinib
March 27, 2024
Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1]. Drug combinations for better treatments Cellular senescence, a state in which cells cannot divide anymore but
First Transplantation of a Pig Kidney into a Human
March 26, 2024
After a total of 69 rejection-preventing gene edits, history has been made with the first-ever successful transplantation of a pig kidney into a human patient. Xenotransplantation within reach Organ transplantation has been one of modern medicine’s biggest triumphs, helping to save innumerable lives. It is also
An Experimental Brain Protector May Fight Obesity
March 25, 2024
According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed compound CMS121, the focus of this study, was created by modifying fisetin, a flavonol that is
Glial Cells and Neurons Mutate Differently
March 24, 2024
In Cell, researchers have published a paper outlining the different ways in which brain cells slowly mutate with aging. The genomic damage of aging Cells accumulate mutations with aging, including brain cells [1]. However, as these researchers note, most previous research into these mutations has been
David Sinclair Hopes Rejuvenation Possible in a Few Decades
March 22, 2024
In this new interview, David Sinclair, Harvard professor and the author of “Lifespan”, explains his theory of aging, shares parts of his health routine, and reveals which directions in today’s aging research excite him. A professor and a public figure In the longevity field, when it
Epigenetic Memory Might Underlie Multiple Sclerosis
March 21, 2024
In an in-depth paper in Nature, researchers have explained how astrocytes, helper cells that provide crucial brain functions, epigenetically remember things in a way that encourages inflammation. Traumatized cells Long-lived immune cells, including T cells and B cells, can remember foreign pathogens [1]. This is why
Springtime and a Time for Growth in the Rejuvenation Field
March 21, 2024
Spring is in the air if you are in the Northern Hemisphere, and in the theme of new growth, let’s see what the lifespan.io team has been up to recently. Happy Birthday to lifespan.io Today, March 21st, it is our birthday, and we celebrate 10 years
Caloric Restriction in Primates Leads to Gut Changes
March 20, 2024
In a recent Nature Communications paper, the researchers investigated changes in weight, metabolism, and microbiome that resulted from periodic restricted feeding in non-human primates [1]. Continuous vs. time-restricted caloric restriction Caloric restriction, which limits the amount of calories an organism consumes, is a widely known lifespan-extending
Journal Club Episode 2 – 2024
March 20, 2024
The Journal Club returns to the lifespan.io Facebook page with Dr. Oliver Medvedik as your host on Friday, March 22nd at 12:00 Eastern time. This new paper further explores the approach of using light and sound stimulation to help combat Alzheimer’s disease. The Mindset project This
How to Test One Million Molecules
March 19, 2024
Ora Biomedical has created a robot for high-throughput screening of life-extending compounds in worms, and you can buy an experiment for 100 dollars. Things in the longevity field look bright or gloomy, depending on who you ask. It is true that we now understand much more
A Small Molecule to Restore the Liver
March 18, 2024
In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn’t regenerate The researchers note that the liver has a “nearly unlimited regenerative potential” under healthy circumstances.
Study Suggests 14 Existing Drugs Increase Human Lifespan
March 15, 2024
Scientists have used a huge database to find links between existing drugs and human lifespan. Only 14 of more than 400 showed a positive correlation [1]. Reinventing the wheel? One of the subfields in geroscience was born from the idea that some drugs currently in use
Controlling a Protein to Stop Obesity
March 14, 2024
In GeroScience, researchers have described how turning off a specific protein prevents mice from getting obese in old age. Mimicking hypoxia Hypoxia-inducible factors (HIFs) are a collection of three proteins that are sensitive to oxygen, and, like their name suggests, they normally activate when a cell
InSilico Shares Details on AI-Generated Drug Candidate
March 14, 2024
In a new paper, InSilico has reported on its impressive success with a drug against idiopathic pulmonary fibrosis that was created by AI “from A to Z” and is currently in Phase 2 trials [1]. AI against aging Many people in the longevity community hope that
Senolytic Activity of Drug-Polyphenol Combinations
March 13, 2024
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Various drugs are being used to address some of the problems associated with cellular senescence. For example, some