Category: News
Association Between BMI and Mortality Revisited
March 1, 2023
In a new paper, Ryan K. Masters, professor at CU Boulder, suggests that when adjusted for body shape and lifelong shifts, the relationship between BMI and mortality is more linear
Rejuvenation Roundup February 2023
March 1, 2023
We continue to grow as an organization and in readership, but the fight against aging is far from over. Here’s what’s been done in February. lifespan.io News Team and activities
Ending Atherosclerosis: Cyclarity and Dr. Matthew O’Connor
February 28, 2023
Cyclarity Therapeutics is striving to make powerful treatments for cardiovascular disease and, most importantly, make them accessible and affordable. Their cutting-edge cyclodextrin technology targets atherosclerosis, aiming to eliminate the buildup
Chris Mirabile on the NOVOS Approach
February 28, 2023
With multiple experts on its scientific advisory board, NOVOS offers supplements containing ingredients that recent research has linked to longevity. This company also markets biological age tests for people who
Nonlinear Analysis for a Better Epigenetic Clock
February 27, 2023
A team publishing in Human Genomics has developed a new model for analyzing epigenetic changes that uses nonlinear analysis. Current clocks are linear Current epigenetic clocks, including the original Horvath
Senescent Cells Contribute to Brain Cancer
February 26, 2023
Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly,
Removal of Neuronal APOE4 Alleviates Alzheimer’s in Mice
February 24, 2023
In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse
The State of the Art in Immune Cell Therapy
February 23, 2023
A pair of researchers from Stanford University have published a detailed review of the current state of CAR T immune cell therapies in Nature. A new state of the art
Caloric Restriction Might Slow Down Human Aging
February 22, 2023
In a paper published in Nature Aging, researchers have shown that caloric restriction modestly slows down the pace of aging in healthy young people as measured by one of the
High Protein Intake Associated With Sarcopenia
February 22, 2023
Researchers publishing in Age and Ageing have found that, rather than being protective, an increase in dietary protein is associated with an increased chance of sarcopenia. Sarcopenia is a well-known
Our Organization Grows to Support Rejuvenation Research
February 22, 2023
Spring is not far away here in the Northern Hemisphere, and with it, the signs of life and new growth are appearing. Much like the change of seasons, our organization
Midday Exercise Might Be Better In Preventing Mortality
February 21, 2023
Scientists have found that the time of day when you exercise might be an important factor in lowering all-cause and cardiovascular mortality [1]. Exercise is good, but what about timing?
Journal Club February 2023
February 21, 2023
The Journal Club, hosted by Dr. Oliver Medvedik, returns to the lifespan.io Facebook page at 12:00 on Tuesday, February 28th. This month, we are covering a recent paper that showed
Reviewing David Sinclair’s First Lifespan Book
February 20, 2023
David Sinclair, PhD, esteemed molecular geneticist at Harvard, believes that aging is a disease that should be attacked at its roots. Furthermore, he believes if we are to make efficient
High Cholesterol Associated With Lower Bone Mineral Density
February 18, 2023
A team of researchers has described an association between reduced bone density in the lumbar spine and high total cholesterol in a paper published in Aging. Previous studies were conflicting
Association Between BMI and Mortality Revisited
March 1, 2023
In a new paper, Ryan K. Masters, professor at CU Boulder, suggests that when adjusted for body shape and lifelong shifts, the relationship between BMI and mortality is more linear and robust than previously thought, with normal BMI being the healthiest [1]. BMI’s many problems Most
Rejuvenation Roundup February 2023
March 1, 2023
We continue to grow as an organization and in readership, but the fight against aging is far from over. Here’s what’s been done in February. lifespan.io News Team and activities Our Organization Grows to Support Rejuvenation Research: Spring is not far away here in the Northern
Ending Atherosclerosis: Cyclarity and Dr. Matthew O’Connor
February 28, 2023
Cyclarity Therapeutics is striving to make powerful treatments for cardiovascular disease and, most importantly, make them accessible and affordable. Their cutting-edge cyclodextrin technology targets atherosclerosis, aiming to eliminate the buildup of non-degradable oxidized cholesterol that gets stuck inside cells in the arterial walls. The company has
Chris Mirabile on the NOVOS Approach
February 28, 2023
With multiple experts on its scientific advisory board, NOVOS offers supplements containing ingredients that recent research has linked to longevity. This company also markets biological age tests for people who want to monitor their progress. We spoke with NOVOS founder and CEO Chris Mirabile about the
Nonlinear Analysis for a Better Epigenetic Clock
February 27, 2023
A team publishing in Human Genomics has developed a new model for analyzing epigenetic changes that uses nonlinear analysis. Current clocks are linear Current epigenetic clocks, including the original Horvath clock and the death-predicting GrimAge, use linear analyses of methylation sites to estimate biological age. However,
Senescent Cells Contribute to Brain Cancer
February 26, 2023
Combining results from human tumors and a mouse model, researchers publishing in Nature Communications have shown that senescent cells promote the growth of glioblastoma, a form of brain cancer. Deadly, aggressive, and hard to treat Glioblastoma is one of the most dangerous forms of cancer. Even
Removal of Neuronal APOE4 Alleviates Alzheimer’s in Mice
February 24, 2023
In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse model [1]. The dreadful allele An infamous variant of the APOE gene, APOE4, is the strongest
The State of the Art in Immune Cell Therapy
February 23, 2023
A pair of researchers from Stanford University have published a detailed review of the current state of CAR T immune cell therapies in Nature. A new state of the art in fighting cancer Chimeric antigen receptor (CAR) is a technology that allows researchers to alter T
Caloric Restriction Might Slow Down Human Aging
February 22, 2023
In a paper published in Nature Aging, researchers have shown that caloric restriction modestly slows down the pace of aging in healthy young people as measured by one of the DNA methylation clocks [1]. CALERIE design A plethora of animal data has shown beneficial effects of
High Protein Intake Associated With Sarcopenia
February 22, 2023
Researchers publishing in Age and Ageing have found that, rather than being protective, an increase in dietary protein is associated with an increased chance of sarcopenia. Sarcopenia is a well-known disorder that occurs with aging. People with sarcopenia lack adequate muscular function, leading to frailty, a
Our Organization Grows to Support Rejuvenation Research
February 22, 2023
Spring is not far away here in the Northern Hemisphere, and with it, the signs of life and new growth are appearing. Much like the change of seasons, our organization is also growing and preparing to continue the fight against age-related diseases. Matt Kaeberlein joins our
Midday Exercise Might Be Better In Preventing Mortality
February 21, 2023
Scientists have found that the time of day when you exercise might be an important factor in lowering all-cause and cardiovascular mortality [1]. Exercise is good, but what about timing? The value of physical activity for health and longevity is unquestionable [2], even if some doubts
Journal Club February 2023
February 21, 2023
The Journal Club, hosted by Dr. Oliver Medvedik, returns to the lifespan.io Facebook page at 12:00 on Tuesday, February 28th. This month, we are covering a recent paper that showed a method of restoring youthful collagen production in aged skin [1]. If you would like some
Reviewing David Sinclair’s First Lifespan Book
February 20, 2023
David Sinclair, PhD, esteemed molecular geneticist at Harvard, believes that aging is a disease that should be attacked at its roots. Furthermore, he believes if we are to make efficient and sensible use our medical resources, we must move away from the “whack-a-mole” approach to treating
High Cholesterol Associated With Lower Bone Mineral Density
February 18, 2023
A team of researchers has described an association between reduced bone density in the lumbar spine and high total cholesterol in a paper published in Aging. Previous studies were conflicting In various populations, conflicting evidence has been found regarding a relationship between cholesterol and bone density.