Category: Biology of Aging
Study Suggests Trade-Offs Between Reproduction and Lifespan
January 2, 2024
Scientists might have found support for the antagonistic pleiotropy theory of aging, which suggests that evolution selects some genetic traits that are associated with shorter lifespans because they also help
A New Anti-Inflammatory Approach for Arthritis
December 21, 2023
In Aging, researchers have published their tests of a compound that counteracts the effects of tumor necrosis factor alpha (TNF-α), an inflammatory factor that promotes arthritis. Current anti-inflammatories aren’t enough
David Sinclair Presents His Information Theory of Aging
December 19, 2023
In a new paper, Sinclair and his co-authors outline a theory arguing that epigenetic changes are the underlying cause of aging [1]. When cells get old It is not every
A Clinical Trial of Neural Stem Cells for MS
December 18, 2023
In Cell Stem Cell, researchers have published the results of a Phase 1 clinical trial of a treatment that uses neural stem cells (NSCs) to treat multiple sclerosis. Looking for
Predicting the Aging of Individual Organs
December 15, 2023
In Nature, a team has published its research on using protein analysis to estimate the aging of specific organs. Aging is not all at once While the processes of aging
David Sinclair’s Group Reverses Glaucoma in Mice
December 12, 2023
In a new study, scientists have achieved significant improvement of glaucoma in a mouse model via partial cellular reprogramming of retinal cells. However, it might take more than that to
Repairing DNA with Sirtuins for Arthritis
December 11, 2023
In a paper published on Saturday in Aging, researchers have described a method of activating the sirtuin SIRT6 to reduce DNA damage, reducing senescence and possibly treating arthritis. Sirtuins, genetic
Journal Club December – Improving Mitochrondrial Function
December 11, 2023
The Journal Club is back for one final time this year! Dr. Oliver Medvedik will return on December 15th at 12:00 Eastern on the lifespan.io Facebook page to review the
Boosting Mitochondrial Function
December 11, 2023
The Journal Club is back for one final time this year! Dr. Oliver Medvedik will return on December 15th at 12:00 Eastern on the lifespan.io Facebook page to review the
Astaxanthin and Meclizine Extend Lifespan in Mice
December 7, 2023
Scientists in the Intervention Testing Program have found that the antioxidant astaxanthin and the seasickness medication meclizine, both sold over the counter, significantly extend median lifespan in mice [1]. Astaxanthin
A Microvesicle Hydrogel to Treat Arthritis
December 7, 2023
In the Journal of Nanobiotechnology, researchers have found that embedding microvesicles in a slow-release hydrogel may be an effective treatment for osteoarthritis. A line of inquiry begins to bear fruit
Caloric Restriction Associated With Reduced Senescence
December 6, 2023
New research in Aging Cell has identified senescence-associated biomarkers whose levels are altered by caloric restriction in humans [1]. Slowing down senescence with fewer calories Multiple animal studies have found
Was Mammals’ Longevity Shaped by Living Among Dinosaurs?
December 5, 2023
A prominent geroscientist suggests that more than 100 million years of saurian domination might have deprived mammals of longevity-promoting traits that are found in today’s reptiles [1]. The longevity bottleneck
Pre-Senescent Cells May Be Damaging and Treatable
December 4, 2023
Researchers have described an intermediary state between senescent and young cells, the inflammatory problems caused by these cells, and how young cells secrete a protein that may alleviate these problems.
Mechanically Reprogrammed Fibroblasts for Skin Rejuvenation
December 4, 2023
Scientists have found a way to reprogram fibroblasts without chemicals by culturing them on a surface with specific mechanical properties. Transplanted into aged skin, those cells boosted rejuvenation in a
Study Suggests Trade-Offs Between Reproduction and Lifespan
January 2, 2024
Scientists might have found support for the antagonistic pleiotropy theory of aging, which suggests that evolution selects some genetic traits that are associated with shorter lifespans because they also help us reproduce [1]. Evolution needs you to reproduce, not live long Shouldn’t evolution favor longer lifespans,
A New Anti-Inflammatory Approach for Arthritis
December 21, 2023
In Aging, researchers have published their tests of a compound that counteracts the effects of tumor necrosis factor alpha (TNF-α), an inflammatory factor that promotes arthritis. Current anti-inflammatories aren’t enough Rheumatoid arthritis, an autoimmune disorder that causes joint swelling, pain, and disability, is most often treated
David Sinclair Presents His Information Theory of Aging
December 19, 2023
In a new paper, Sinclair and his co-authors outline a theory arguing that epigenetic changes are the underlying cause of aging [1]. When cells get old It is not every day that one of the most prominent geroscientists presents a new theory of aging. David Sinclair
A Clinical Trial of Neural Stem Cells for MS
December 18, 2023
In Cell Stem Cell, researchers have published the results of a Phase 1 clinical trial of a treatment that uses neural stem cells (NSCs) to treat multiple sclerosis. Looking for better therapies Multiple sclerosis (MS) is a progressive disease that afflicts approximately two million people worldwide
Predicting the Aging of Individual Organs
December 15, 2023
In Nature, a team has published its research on using protein analysis to estimate the aging of specific organs. Aging is not all at once While the processes of aging affect every organ of every person, the rates at which these processes affect these organs can
David Sinclair’s Group Reverses Glaucoma in Mice
December 12, 2023
In a new study, scientists have achieved significant improvement of glaucoma in a mouse model via partial cellular reprogramming of retinal cells. However, it might take more than that to reverse other aspects of age-related vision loss [1]. The vision of restored vision The group that
Repairing DNA with Sirtuins for Arthritis
December 11, 2023
In a paper published on Saturday in Aging, researchers have described a method of activating the sirtuin SIRT6 to reduce DNA damage, reducing senescence and possibly treating arthritis. Sirtuins, genetic damage, and senescence Extensive previous research has found that SIRT6, a deacetylase that is dependent on
Journal Club December – Improving Mitochrondrial Function
December 11, 2023
The Journal Club is back for one final time this year! Dr. Oliver Medvedik will return on December 15th at 12:00 Eastern on the lifespan.io Facebook page to review the recent paper “A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan”.
Boosting Mitochondrial Function
December 11, 2023
The Journal Club is back for one final time this year! Dr. Oliver Medvedik will return on December 15th at 12:00 Eastern on the lifespan.io Facebook page to review the recent paper “A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan”.
Astaxanthin and Meclizine Extend Lifespan in Mice
December 7, 2023
Scientists in the Intervention Testing Program have found that the antioxidant astaxanthin and the seasickness medication meclizine, both sold over the counter, significantly extend median lifespan in mice [1]. Astaxanthin and meclizine are in, but fisetin is out The Intervention Testing Program (ITP) has existed for
A Microvesicle Hydrogel to Treat Arthritis
December 7, 2023
In the Journal of Nanobiotechnology, researchers have found that embedding microvesicles in a slow-release hydrogel may be an effective treatment for osteoarthritis. A line of inquiry begins to bear fruit Researchers have repeatedly found that the extracellular vesicles (EVs) released by stem cells, particularly mesenchymal stem
Caloric Restriction Associated With Reduced Senescence
December 6, 2023
New research in Aging Cell has identified senescence-associated biomarkers whose levels are altered by caloric restriction in humans [1]. Slowing down senescence with fewer calories Multiple animal studies have found that reducing caloric intake without causing malnutrition (caloric restriction) has great lifespan-extending potential and can delay
Was Mammals’ Longevity Shaped by Living Among Dinosaurs?
December 5, 2023
A prominent geroscientist suggests that more than 100 million years of saurian domination might have deprived mammals of longevity-promoting traits that are found in today’s reptiles [1]. The longevity bottleneck Today, mammals rule the world, but, sadly, we only have an average of 80 years to
Pre-Senescent Cells May Be Damaging and Treatable
December 4, 2023
Researchers have described an intermediary state between senescent and young cells, the inflammatory problems caused by these cells, and how young cells secrete a protein that may alleviate these problems. What happens before senescence? As these researchers note, the problems with senescent cells are very well-known
Mechanically Reprogrammed Fibroblasts for Skin Rejuvenation
December 4, 2023
Scientists have found a way to reprogram fibroblasts without chemicals by culturing them on a surface with specific mechanical properties. Transplanted into aged skin, those cells boosted rejuvenation in a human tissue model [1]. We’ve all got skin in the game Skin aging might not be