Category: Biology of Aging
A Protective Mechanism Against AMD
August 22, 2023
A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins
Figuring Out Why Stem Cells Won’t Build Bone
August 21, 2023
Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don’t differentiate into bone-building osteoblasts, unlocking a potential new approach to
Antioxidants Rescue Cognitive Decline in Mice
August 18, 2023
Scientists have found that EGCG and curcumin, two well-known antioxidants, are effective both alone and especially in combination in a mouse model of cognitive decline induced by oxidative stress [1].
Extracellular Vesicles from Stem Cells Reverse Senescence
August 15, 2023
Scientists have found that bubbles secreted by embryonic stem cells counter cellular senescence, in large part due to just two tiny snippets of RNA [1]. Helpful bubbles Extracellular vesicles (EVs)
Restoring Helper Cell Function to Fight Alzheimer’s
August 14, 2023
In a study published in Cell Stem Cell, researchers have investigated a way to repopulate the brain with functional cells in order to fight back against Alzheimer’s disease. A gene
New Senolytics from Artificial Intelligence
August 9, 2023
Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1]. Searching for new senolytics Senolytics are molecules that destroy
Liquid Metal Nanoparticles Eradicate Colon Cancer in Mice
August 9, 2023
Scientists have combined gallium nanoparticles with immunotherapy agents to deliver a decisive blow to colon cancer tumors in mice [1]. Cancer, you are terminated Most moviegoers are familiar with the
The Inflammatory Pathway to Brain Damage
August 7, 2023
Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating
The Flavonoid Rutin May Suppress Senescent Cells
August 3, 2023
Researchers publishing in Aging Cell have documented some potential effects of rutin against senescence and cancer. Rutin is a natural compound found in several plants. Another compound to fight senescence
Impaired Calcium Uptake May Impact Long-Term Inflammation
August 3, 2023
Scientists have reported in Nature Aging that impaired mitochondrial uptake of calcium ions leads to changes in inflammatory responses that resemble what happens in aging [1]. Inflammation and aging Inflammation
A Potential Next Generation For Epigenetic Clocks
June 29, 2023
A study recently published in Aging Cell has discovered an entirely new method of looking at methylation and experimented with multiple ways of analyzing it. Not just a clock While
The Links Between Herpes and Dementia
June 29, 2023
One of the most common diseases in the world is herpes, as 50 to 80% of Americans have this illness. The herpes simplex virus, which causes cold sores, is
Activating A Single Gene Rejuvenates Mice
June 28, 2023
In a new study published in Aging Cell [1], researchers report that transient activation of the Yamanaka factor Oct4 allowed partial reprogramming of cells, which led to rejuvenation in these
Preserved Kidneys Rewarmed and Transplanted in Rats
June 27, 2023
For the first time in history, scientists have been able to freeze, preserve, rewarm, and transplant rat kidneys with a new method of organ cryopreservation [1]. The rewarming problem
Journal Club June 2023
June 24, 2023
For the Journal Club this month, at 12:00 Eastern time on Tuesday, June 27, we are taking a look at the recent paper that explores the reason why the bowhead
A Protective Mechanism Against AMD
August 22, 2023
A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins with a discussion of AMD and its prevalence. AMD is the most common cause of vision
Figuring Out Why Stem Cells Won’t Build Bone
August 21, 2023
Researchers publishing in Aging have uncovered some of the molecular mechanisms behind why mesenchymal stem cells (MSCs) do and don’t differentiate into bone-building osteoblasts, unlocking a potential new approach to osteoporosis. A matter of cellular fate MSCs are downstream of pluripotent stem cells: they can differentiate
Antioxidants Rescue Cognitive Decline in Mice
August 18, 2023
Scientists have found that EGCG and curcumin, two well-known antioxidants, are effective both alone and especially in combination in a mouse model of cognitive decline induced by oxidative stress [1]. Not the usual stress Oxidative stress results mostly from molecules called reactive oxygen species (ROS), which
Extracellular Vesicles from Stem Cells Reverse Senescence
August 15, 2023
Scientists have found that bubbles secreted by embryonic stem cells counter cellular senescence, in large part due to just two tiny snippets of RNA [1]. Helpful bubbles Extracellular vesicles (EVs) are membrane-bound tiny bubbles that are loaded with various molecular cargo, such as proteins, DNA, or
Restoring Helper Cell Function to Fight Alzheimer’s
August 14, 2023
In a study published in Cell Stem Cell, researchers have investigated a way to repopulate the brain with functional cells in order to fight back against Alzheimer’s disease. A gene with a microglial function Various allelles of the apolipoprotein E (APOE) genes are well-known for their
New Senolytics from Artificial Intelligence
August 9, 2023
Recent research published in Nature Communications has used machine learning algorithms to find new compounds that can eliminate senescent cells [1]. Searching for new senolytics Senolytics are molecules that destroy senescent cells. Only a small number of such molecules have been identified, and only two have
Liquid Metal Nanoparticles Eradicate Colon Cancer in Mice
August 9, 2023
Scientists have combined gallium nanoparticles with immunotherapy agents to deliver a decisive blow to colon cancer tumors in mice [1]. Cancer, you are terminated Most moviegoers are familiar with the liquid metal T-1000 from the Terminator series, and everyone knows about mercury, a liquid metal that
The Inflammatory Pathway to Brain Damage
August 7, 2023
Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating a cause-and-effect relationship between initial damage and long-term effects. Perturbed mitochondria release their mitochondrial DNA (mtDNA)
The Flavonoid Rutin May Suppress Senescent Cells
August 3, 2023
Researchers publishing in Aging Cell have documented some potential effects of rutin against senescence and cancer. Rutin is a natural compound found in several plants. Another compound to fight senescence In this study, the researchers place rutin among the many other natural compounds that have demonstrated
Impaired Calcium Uptake May Impact Long-Term Inflammation
August 3, 2023
Scientists have reported in Nature Aging that impaired mitochondrial uptake of calcium ions leads to changes in inflammatory responses that resemble what happens in aging [1]. Inflammation and aging Inflammation is an essential, evolutionarily conserved process and a fundamental part of the immune response, providing immediate
A Potential Next Generation For Epigenetic Clocks
June 29, 2023
A study recently published in Aging Cell has discovered an entirely new method of looking at methylation and experimented with multiple ways of analyzing it. Not just a clock While we have reported extensively on the use of epigenetic methylation clocks, the genes that become activated
The Links Between Herpes and Dementia
June 29, 2023
One of the most common diseases in the world is herpes, as 50 to 80% of Americans have this illness. The herpes simplex virus, which causes cold sores, is normally transmitted through person-to-person contact. This illness leaves the patient with blisters clustered around the mouth.
Activating A Single Gene Rejuvenates Mice
June 28, 2023
In a new study published in Aging Cell [1], researchers report that transient activation of the Yamanaka factor Oct4 allowed partial reprogramming of cells, which led to rejuvenation in these cells and in a mouse model of premature aging. This research used a mouse model of
Preserved Kidneys Rewarmed and Transplanted in Rats
June 27, 2023
For the first time in history, scientists have been able to freeze, preserve, rewarm, and transplant rat kidneys with a new method of organ cryopreservation [1]. The rewarming problem Today, organ transplantation is severely limited by the fact that organs can only be preserved for
Journal Club June 2023
June 24, 2023
For the Journal Club this month, at 12:00 Eastern time on Tuesday, June 27, we are taking a look at the recent paper that explores the reason why the bowhead whale is so long lived. If you want to get up to speed, check out the