Category: Biology of Aging
The Impact of Genetic Risk Factors on Healthspan
October 18, 2022
A research paper published in Nature Medicine has shown the results of a broad investigation into gene variants associated with healthspan [1]. Genome-wide association studies A genome-wide association study is
T Cells Acquire Telomeres from Antigen-Presenting Cells
October 18, 2022
Scientists have found that when T cells are activated by antigen-presenting cells, the activating cells donate chunks of their telomeres to the T cells, preventing senescence [1]. Imperfect protection Telomeres
Older Immune Cells Kill Cancer Cells More Quickly
October 13, 2022
In Aging Cell, researchers have published the surprising and counterintuitive finding that older immune cells are able to kill cancer cells more quickly than their younger counterparts. The aging of
Mitochondria in Different Brain Regions Age Differently
October 12, 2022
In a new study published in Free Radical Biology and Medicine, researchers have identified a link between mitochondrial function and the vulnerability of specific brain regions to age-associated neurodegeneration [1].
Heart Aging Associated With a Bad Gut Microbiome
October 11, 2022
In ESC Heart Failure, researchers have commented about the correlation between a poor gut microbiome and aging of the heart [1]. The microbiome is important in aging Research increasingly suggests
How Cancers Handle Protein Misfolding
October 10, 2022
A preprint published in bioRxiv has shown the mechanisms by which cancer handles the protein dysfunction brought about by its own mutational load and how these mechanisms are different from
Combination of Rapamycin and Acarbose Extends Lifespan
October 5, 2022
In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice
Removing Senescent Cells Improves the Brains of Female Mice
October 4, 2022
Researchers publishing in Nature Communications have detailed how the removal of p16-producing senescent cells leads to improvements in the brains of female mice [1]. Disease-associated microglia and senescence This paper
Short-Term Rapamycin Treatment Extends Lifespan in Flies
October 4, 2022
Journal Club returns live on our Facebook channel on October 25th at 12:00 Eastern time. Dr. Oliver Medvedik will be taking a look at a recent study published in Nature
Methuselah’s Zoo, a Look at Animal Longevity
September 30, 2022
To understand human longevity, we need to put it into perspective. Are we relatively long-lived or short-lived creatures? After all, among all the plants and animals in nature, we find
Nanoplastics Cause Mitochondrial Stress in Human Cells
September 29, 2022
A paper published in Environmental Science and Technology has described some of the effects of nanoplastics on human liver and lung cells [1]. Microplastics and nanoplastics Plastics in the environment
A Link Between Obesity And Joint Degeneration
September 28, 2022
In a new study published in Scientific Reports, researchers have uncovered the molecular mechanism underlying the link between obesity and joint degeneration [1]. Obesity and osteoarthritis Obesity accelerates aging and
Fundamental Metabolic Changes Accompany Alzheimer’s Disease
September 26, 2022
A paper published in Cell Metabolism has reported on a metabolic shift in neurons derived from patients with Alzheimer’s disease, showing that they express a cancer-like phenotype [1]. Induced neurons
A Wearable Tracker For Metabolites, Nutrients, and Drugs
September 23, 2022
Today, we want to highlight an interesting development on the wearable diagnostic front: researchers have developed a wearable device that can monitor nutrients, hormones, and drugs [1]. Real-time health monitoring
Transplanting B Cells from Old to Young Mice Improves Them
September 22, 2022
Researchers have recently explored why B cells become less efficient as we age, analyzing how their behavior changes when they are transplanted from aged mice into young mice [1]. The
The Impact of Genetic Risk Factors on Healthspan
October 18, 2022
A research paper published in Nature Medicine has shown the results of a broad investigation into gene variants associated with healthspan [1]. Genome-wide association studies A genome-wide association study is an effort to use enormous databases and computational analysis to examine the genetic causes of disease
T Cells Acquire Telomeres from Antigen-Presenting Cells
October 18, 2022
Scientists have found that when T cells are activated by antigen-presenting cells, the activating cells donate chunks of their telomeres to the T cells, preventing senescence [1]. Imperfect protection Telomeres are sequences of TTAGGG repeats at the ends of our chromosomes that protect their integrity. Because
Older Immune Cells Kill Cancer Cells More Quickly
October 13, 2022
In Aging Cell, researchers have published the surprising and counterintuitive finding that older immune cells are able to kill cancer cells more quickly than their younger counterparts. The aging of CD8+ T cells The researchers introduce their subject by discussing CD8+ T cells in the context
Mitochondria in Different Brain Regions Age Differently
October 12, 2022
In a new study published in Free Radical Biology and Medicine, researchers have identified a link between mitochondrial function and the vulnerability of specific brain regions to age-associated neurodegeneration [1]. Brain region-specific vulnerability It is well-known that the human brain is heterogeneous in terms of structure
Heart Aging Associated With a Bad Gut Microbiome
October 11, 2022
In ESC Heart Failure, researchers have commented about the correlation between a poor gut microbiome and aging of the heart [1]. The microbiome is important in aging Research increasingly suggests that the quality and composition of the gut microbiome may play a role as important as
How Cancers Handle Protein Misfolding
October 10, 2022
A preprint published in bioRxiv has shown the mechanisms by which cancer handles the protein dysfunction brought about by its own mutational load and how these mechanisms are different from ordinary proteostasis machinery. A highly variable burden Previous research has shown that tumors vary widely in
Combination of Rapamycin and Acarbose Extends Lifespan
October 5, 2022
In a new study published in Aging Cell, researchers have tested several individual drugs and a combination of rapamycin plus acarbose as potential life extension agents in genetically heterogeneous mice [1]. Anti-aging agent testing Identification of successful anti-aging interventions is arguably one of the most challenging
Removing Senescent Cells Improves the Brains of Female Mice
October 4, 2022
Researchers publishing in Nature Communications have detailed how the removal of p16-producing senescent cells leads to improvements in the brains of female mice [1]. Disease-associated microglia and senescence This paper begins with a discussion of disease-associated microglia (DAM) and white matter-associated microglia (WAM). In the aging
Short-Term Rapamycin Treatment Extends Lifespan in Flies
October 4, 2022
Journal Club returns live on our Facebook channel on October 25th at 12:00 Eastern time. Dr. Oliver Medvedik will be taking a look at a recent study published in Nature Aging that has shown that short-term rapamycin treatment in early adulthood extends lifespan in flies and
Methuselah’s Zoo, a Look at Animal Longevity
September 30, 2022
To understand human longevity, we need to put it into perspective. Are we relatively long-lived or short-lived creatures? After all, among all the plants and animals in nature, we find a vast variety of lifespans, from several hours to several millennia, and possibly even more. While
Nanoplastics Cause Mitochondrial Stress in Human Cells
September 29, 2022
A paper published in Environmental Science and Technology has described some of the effects of nanoplastics on human liver and lung cells [1]. Microplastics and nanoplastics Plastics in the environment are gradually broken down by sunlight, grinding processes, and biological activities into smaller and smaller pieces
A Link Between Obesity And Joint Degeneration
September 28, 2022
In a new study published in Scientific Reports, researchers have uncovered the molecular mechanism underlying the link between obesity and joint degeneration [1]. Obesity and osteoarthritis Obesity accelerates aging and is associated with several age-associated diseases, including osteoarthritis, an inflammatory condition that leads to joint degeneration.
Fundamental Metabolic Changes Accompany Alzheimer’s Disease
September 26, 2022
A paper published in Cell Metabolism has reported on a metabolic shift in neurons derived from patients with Alzheimer’s disease, showing that they express a cancer-like phenotype [1]. Induced neurons Rather than attempting to harvest live neurons from Alzheimer’s patients, the researchers chose to create induced
A Wearable Tracker For Metabolites, Nutrients, and Drugs
September 23, 2022
Today, we want to highlight an interesting development on the wearable diagnostic front: researchers have developed a wearable device that can monitor nutrients, hormones, and drugs [1]. Real-time health monitoring The popularity of medical wearables has increased in recent years. A few decades ago, a complex
Transplanting B Cells from Old to Young Mice Improves Them
September 22, 2022
Researchers have recently explored why B cells become less efficient as we age, analyzing how their behavior changes when they are transplanted from aged mice into young mice [1]. The immune system is a comprehensive defense system Our immune systems protect us from disease and are