Category: Research
Examining Cellular Stemness as a Tissue Attribute
April 24, 2023
In a preprint paper published on bioRxiv, researchers including João Pedro de Magalhães have gotten a glimpse at how stemness declines across tissues with aging. Using AI to get a
Sleep Quality and Duration Associated with Stroke
April 21, 2023
Showing yet again that sleep is a serious matter, scientists have reported that short sleep duration, snoring, and long naps are linked to a significantly elevated risk of acute stroke
Case Reports of Sclerotic Fibrosis in the Heart
April 19, 2023
A pair of case reports published in Heliyon have shed more light on the connection between systemic sclerosis and fatal heart failure, highlighting a need for early diagnosis and treatment.
Amyloid-β Clearance by the Liver Might Help with Alzheimer’s
April 19, 2023
Chinese scientists have found that the liver removes amyloid-β from circulation in mice, which also decreases its levels in the brain. The age-related impairment of this process might offer a
Rapamycin Rescues Age-Impaired Blood Flow in Mice
April 18, 2023
Scientists have concluded that rapamycin treatment started in early mid-life can prevent age-related blood flow impairment in the hindlimbs of wild-type, atherosclerotic, and Alzheimer’s model mice [1]. PAD and aging
Heart Organoids May Change Future Research
April 17, 2023
Researchers publishing in Nature Biotechnology have generated epicardioids, which are pluripotent, self-organizing stem cells that allow for better understanding, research, and potentially prevention and treatment of heart disease. A background
Longevity Prize Announces First Winners
April 13, 2023
The winners of the Hypothesis Prize have been announced as part of the Longevity Prize initiative. This is an important step for funding rejuvenation research and sets a great precedent
Age-Related Changes in RNA Transcription Speed
April 13, 2023
Research published yesterday in Nature has described one way in which RNA sequencing changes in the cell with age and how this may be linked to lifespan. Transcriptional elongation Transcriptional
Examining a Factor in the Diabetic Heart
April 12, 2023
Research published in Heliyon has outlined the effects of F-Klb, a signaling molecule receptor that is released under metabolic stress, on the hearts of diabetic patients. A protector that loses
Air Pollution Promotes Cancer Through Inflammation
April 11, 2023
Researchers have concluded that airborne fine particulate matter, which has been consistently linked to cancer, promotes lung cancer via inflammation and not necessarily via mutagenesis [1]. Not just mutations Common
Reducing Axonal Death and Inflammation in Mouse Brains
April 10, 2023
Researchers have published a study in Aging Cell on how inhibiting the death of axons in the brain protects the brains of old mice from inflammation. Necroptosis in the brain
Young Microbiomes in Very Old People
April 6, 2023
Research published today in Nature Aging has illustrated how the gut microbiomes of the longest-lived people are more likely to have bacterial populations associated with youth. A known difference This
Cold Temperatures Stimulate Lifespan-Associated Protein
April 3, 2023
A paper published today in Nature Aging describes how cold temperatures stimulate the production of PA28γ, a protein that appears to increase lifespan in worms and cells. An explanation for
Daily Step Count, Less Mortality, Diminishing Returns
March 31, 2023
A new study using wearable accelerometers suggests that you don’t have to clock extreme numbers of steps every day to stay healthy [1]. Do you always need to hit the
Using AI to Measure Age Through the Eyes
March 30, 2023
An accepted manuscript in eLife Sciences has described eyeAge, a new clock that uses deep learning to analyze the eye in detail in order to predict chronological age and age acceleration.
Examining Cellular Stemness as a Tissue Attribute
April 24, 2023
In a preprint paper published on bioRxiv, researchers including João Pedro de Magalhães have gotten a glimpse at how stemness declines across tissues with aging. Using AI to get a grasp on stemness As expected, this paper begins with a discussion of stem cell exhaustion and
Sleep Quality and Duration Associated with Stroke
April 21, 2023
Showing yet again that sleep is a serious matter, scientists have reported that short sleep duration, snoring, and long naps are linked to a significantly elevated risk of acute stroke [1]. Debilitating and deadly Stroke, an acute condition in which the blood supply to a part
Case Reports of Sclerotic Fibrosis in the Heart
April 19, 2023
A pair of case reports published in Heliyon have shed more light on the connection between systemic sclerosis and fatal heart failure, highlighting a need for early diagnosis and treatment. A systemic autoimmune disease Systemic sclerosis was once known as scleroderma, as the most visible signs
Amyloid-β Clearance by the Liver Might Help with Alzheimer’s
April 19, 2023
Chinese scientists have found that the liver removes amyloid-β from circulation in mice, which also decreases its levels in the brain. The age-related impairment of this process might offer a new clue for fighting Alzheimer’s disease [1]. The janitor of the body Despite the flop-laden history
Rapamycin Rescues Age-Impaired Blood Flow in Mice
April 18, 2023
Scientists have concluded that rapamycin treatment started in early mid-life can prevent age-related blood flow impairment in the hindlimbs of wild-type, atherosclerotic, and Alzheimer’s model mice [1]. PAD and aging Peripheral artery disease (PAD) is defined as reduced blood flow to the lower limbs. Age is
Heart Organoids May Change Future Research
April 17, 2023
Researchers publishing in Nature Biotechnology have generated epicardioids, which are pluripotent, self-organizing stem cells that allow for better understanding, research, and potentially prevention and treatment of heart disease. A background of heart development The epicardium, a layer of cells surrounding the heart, plays a major role
Longevity Prize Announces First Winners
April 13, 2023
The winners of the Hypothesis Prize have been announced as part of the Longevity Prize initiative. This is an important step for funding rejuvenation research and sets a great precedent for future longevity-focused prizes and open science. Introducing the Longevity Prize The Longevity Prize is a
Age-Related Changes in RNA Transcription Speed
April 13, 2023
Research published yesterday in Nature has described one way in which RNA sequencing changes in the cell with age and how this may be linked to lifespan. Transcriptional elongation Transcriptional elongation is a fundamental biological process, as it affects the basic steps involved in the production
Examining a Factor in the Diabetic Heart
April 12, 2023
Research published in Heliyon has outlined the effects of F-Klb, a signaling molecule receptor that is released under metabolic stress, on the hearts of diabetic patients. A protector that loses its effectiveness Fibroblast growth factor 21 (FGF21) is a regulator of metabolism that is produced both
Air Pollution Promotes Cancer Through Inflammation
April 11, 2023
Researchers have concluded that airborne fine particulate matter, which has been consistently linked to cancer, promotes lung cancer via inflammation and not necessarily via mutagenesis [1]. Not just mutations Common wisdom says that carcinogens increase cancer risk mostly by promoting oncogenic mutations. Research has reported that
Reducing Axonal Death and Inflammation in Mouse Brains
April 10, 2023
Researchers have published a study in Aging Cell on how inhibiting the death of axons in the brain protects the brains of old mice from inflammation. Necroptosis in the brain It is well-known that aged organisms have problems with cognitive function, and this is strongly linked
Young Microbiomes in Very Old People
April 6, 2023
Research published today in Nature Aging has illustrated how the gut microbiomes of the longest-lived people are more likely to have bacterial populations associated with youth. A known difference This is far from the first study showing a connection between a healthy, youthful microbiome and enhanced
Cold Temperatures Stimulate Lifespan-Associated Protein
April 3, 2023
A paper published today in Nature Aging describes how cold temperatures stimulate the production of PA28γ, a protein that appears to increase lifespan in worms and cells. An explanation for a commonly held belief Cold temperatures have been associated with longevity for more than a hundred
Daily Step Count, Less Mortality, Diminishing Returns
March 31, 2023
A new study using wearable accelerometers suggests that you don’t have to clock extreme numbers of steps every day to stay healthy [1]. Do you always need to hit the target? A tight association between physical activity and health is widely known [2]. In fact, staying
Using AI to Measure Age Through the Eyes
March 30, 2023
An accepted manuscript in eLife Sciences has described eyeAge, a new clock that uses deep learning to analyze the eye in detail in order to predict chronological age and age acceleration. Retinal signs of aging This project was developed with the knowledge that fundus imagery, which shows