Category: Research
Not All Hallmarks of Aging Contribute to Epigenetic Age
May 31, 2022
Scientists have shown that only some of the hallmarks of aging affect methylation clocks that are used to measure biological age [1]. The big black box Epigenetic clocks that measure
Chloroquine Increases Lifespan in Male Mice
May 30, 2022
Researchers publishing in Aging have found that the anti-malarial drug chloroquine increases lifespan in male NRMI mice. The NRMI, like the Black 6, is a standard breed widely used in
Plasmalogens Alleviate Age-Related Cognitive Decline in Mice
May 27, 2022
Scientists have learned that plasmalogens, obscure but important lipids, serve as a mediator of neurogenesis and synaptic health and can reverse age-related cognitive decline in mice [1]. Plasmalogens and membranes
Visually Identifying Senescent Cells with an Algorithm
May 26, 2022
A team of researchers publishing in Aging has developed a method of identifying senescent cells through their physical morphology, potentially making future senescence research much easier. Senescent cells look different
Blood Pressure Linked to Dementia, Mortality in Older People
May 25, 2022
A recent study from the Journal of the American College of Cardiology, conducted by Dr. Wuxiang Xie and colleagues, examined the association of blood pressure with cognitive decline, dementia, and
Lithium Use Might Lower Risk of Dementia
May 25, 2022
A study published in Plos Medicine has shown that lithium decreases the risk of developing dementia and some of its subtypes, including Alzheimer’s disease and vascular dementia [1]. Enigmatic but
Young Cerebrospinal Fluid Improves Memory in Mice
May 24, 2022
Scientists have found that infusing old mice with cerebrospinal fluid obtained from young mice improves their memory by increasing proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) [1]. The fountain
Biological Aging Fluctuates with Stress
May 23, 2022
A preprint published in bioRxiv has demonstrated that the second-generation aging clocks PhenoAge, DunedinPACE, and GrimAge show increased but reversible age acceleration in mice and people exposed to significant stress.
“The Perfect Diet” May Increase Lifespan by 13 Years
May 20, 2022
Scientists from Norway have built a model that predicts the effect of various dietary changes on human lifespan [1]. Diet is obviously a major health factor, but quantifying its impact
The Role of Mitochondrial Antioxidants in Longevity
May 19, 2022
A study published in Redox Biology has reported that the upregulation of thioredoxin, a fundamental part of mitochondrial defense against reactive oxygen species, is associated with longevity in mutant C.
FOXM1 Induction Extends Lifespan in Mice
May 18, 2022
In a new study published in Nature Aging, researchers have shown that inducing a truncated FOXM1 gene extends lifespan in both progeric and naturally aging mice [1]. FOXO genes and
The Development of Glowing Pluripotent Cells
May 16, 2022
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Using a lentivirus, the researchers genetically
Using an Endemic Virus as a Gene Therapy for Life Extension
May 12, 2022
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of
Walking Pace Correlated with Increased Telomere Length
May 11, 2022
Publishing in Nature Communications, Dr. Tom Yate, Dr. Neliesh J. Samani, and colleagues used data from approximately 400,000 people in the UK Biobank in order to examine the relationship between
Drug Cocktail Delays Aging in Mice
May 10, 2022
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In
Not All Hallmarks of Aging Contribute to Epigenetic Age
May 31, 2022
Scientists have shown that only some of the hallmarks of aging affect methylation clocks that are used to measure biological age [1]. The big black box Epigenetic clocks that measure biological age based on aging-related changes in genome methylation have been a great success. They enable
Chloroquine Increases Lifespan in Male Mice
May 30, 2022
Researchers publishing in Aging have found that the anti-malarial drug chloroquine increases lifespan in male NRMI mice. The NRMI, like the Black 6, is a standard breed widely used in research, and these mice were not directly genetically modified. Substantial positive lifespan effects We have previously
Plasmalogens Alleviate Age-Related Cognitive Decline in Mice
May 27, 2022
Scientists have learned that plasmalogens, obscure but important lipids, serve as a mediator of neurogenesis and synaptic health and can reverse age-related cognitive decline in mice [1]. Plasmalogens and membranes Plasmalogens are a subtype of phospholipids, the molecules that cellular membranes are mostly made of. Plasmalogens
Visually Identifying Senescent Cells with an Algorithm
May 26, 2022
A team of researchers publishing in Aging has developed a method of identifying senescent cells through their physical morphology, potentially making future senescence research much easier. Senescent cells look different Before modern biomarkers of senescence were eludicated, cell size was considered to be one of its
Blood Pressure Linked to Dementia, Mortality in Older People
May 25, 2022
A recent study from the Journal of the American College of Cardiology, conducted by Dr. Wuxiang Xie and colleagues, examined the association of blood pressure with cognitive decline, dementia, and mortality [1]. This study included two cohorts: the English Longitudinal Study of Ageing (ELSA) and the
Lithium Use Might Lower Risk of Dementia
May 25, 2022
A study published in Plos Medicine has shown that lithium decreases the risk of developing dementia and some of its subtypes, including Alzheimer’s disease and vascular dementia [1]. Enigmatic but effective According to WHO, Alzheimer’s disease and other dementias were the second-leading cause of death in
Young Cerebrospinal Fluid Improves Memory in Mice
May 24, 2022
Scientists have found that infusing old mice with cerebrospinal fluid obtained from young mice improves their memory by increasing proliferation and differentiation of oligodendrocyte progenitor cells (OPCs) [1]. The fountain of brain youth It has been known for years that blood from young animals can alleviate
Biological Aging Fluctuates with Stress
May 23, 2022
A preprint published in bioRxiv has demonstrated that the second-generation aging clocks PhenoAge, DunedinPACE, and GrimAge show increased but reversible age acceleration in mice and people exposed to significant stress. What clocks are for As the researchers remind us, epigenetic clocks measure “how old you are”
“The Perfect Diet” May Increase Lifespan by 13 Years
May 20, 2022
Scientists from Norway have built a model that predicts the effect of various dietary changes on human lifespan [1]. Diet is obviously a major health factor, but quantifying its impact is not easy. Since it is all but impossible to conduct a controlled study of how
The Role of Mitochondrial Antioxidants in Longevity
May 19, 2022
A study published in Redox Biology has reported that the upregulation of thioredoxin, a fundamental part of mitochondrial defense against reactive oxygen species, is associated with longevity in mutant C. elegans worms. Free radicals, revisited The free radical theory of aging, which focuses on reactive oxygen
FOXM1 Induction Extends Lifespan in Mice
May 18, 2022
In a new study published in Nature Aging, researchers have shown that inducing a truncated FOXM1 gene extends lifespan in both progeric and naturally aging mice [1]. FOXO genes and longevity Forkhead box (FOX) genes are transcription factors: genes that drive the expression of other genes
The Development of Glowing Pluripotent Cells
May 16, 2022
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Using a lentivirus, the researchers genetically engineered mouse embryos to express green fluorescent protein (GFP) when it expresses the Yamanaka factor Oct4.
Using an Endemic Virus as a Gene Therapy for Life Extension
May 12, 2022
In a study printed in PNAS, researchers have shown that telomerase reverse transcriptase (TERT) can be given to cells in living mice through a viral vector, taking the idea of life-extending gene therapies from science fiction to reality. Why a cytomegalovirus? The human cytomegalovirus (CMV) is
Walking Pace Correlated with Increased Telomere Length
May 11, 2022
Publishing in Nature Communications, Dr. Tom Yate, Dr. Neliesh J. Samani, and colleagues used data from approximately 400,000 people in the UK Biobank in order to examine the relationship between walking pace and telomere length. Previous evidence suggests that increased physical activity and cardiorespiratory fitness is
Drug Cocktail Delays Aging in Mice
May 10, 2022
Scientists have shown that a combination of rapamycin, acarbose, and phenylbutyrate has a synergetic rejuvenation effect when administered to 20-month-old mice for three months [1]. Fighting on multiple fronts In this paper, the authors argue that to tackle such a multifaced process as aging, it might