Josh Conway

In Aging Cell, researchers have elucidated the relationship between intestinal aging and age-related changes to the gut microbiome. Two interdependent biologies The human gut works through the interaction of two entirely different sets of cells. The first is the body's actual cells, including the intestinal barrier between the gut and the rest of the body,...

Aging is a multifaceted topic, and it's becoming more and more clear that the only way to deal with it is piece by piece. Here's what pieces our industry has put together in April. Advocacy and Analysis It's Springtime and the Rejuvenation Field Is Flourishing: For those of us in the Northern Hemisphere, spring is...

A perspective published in Aging Cell details the replacement-based approaches being investigated by several research organizations. Repair versus replacement This perspective begins by noting the inherent difficulty of rejuvenating the human body because of the vast variety of interventions that need to be performed at multiple levels, from the molecular to the whole-body. It defines...

A team of scientists has examined how younger and older mice heal from wounds and found that more robust senescent cell activation in younger animals helps them heal faster. A double-edged sword Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they...

A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying together two well-known aspects of aging Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious...

In Aging Cell, researchers have described how suppressing the ghrelin receptor improves muscle function and fights sarcopenia in older mice. An appetite hormone with negative effects Ghrelin has been well-documented as stimulating both appetite and growth [1]. However, this hormone, which increases with aging [2], has negative effects in older organisms; deleting ghrelin has been...