Josh Conway

A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different...

A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to...

In Aging Cell, researchers have published an explanation of how neutrophil extracellular traps (NETs) worsen UVB damage and how inhibiting them alleviated this damage in a mouse model. When defenders just make things worse Immune activation is a common response to damage, as the immune system often perceives such damage as a pathogenic attack. Activation...

Autophagy, which increases in younger mice under toxic stress, does not increase in older mice and leaves them susceptible to acute kidney injury (AKI). Increasing autophagic flux by targeting a key molecule, transcription factor EB (TFEB), alleviates some of this damage. An acute disease with lasting effects AKI is a rapidly developing condition that causes...

Researchers have described a method of using exosomes derived from mesenchymal stem cells (MSCs) to fight harmful metabolic changes in the liver. Another look at exosomes This is far from the first attempt at using MSC-derived exosomes, particularly exosomes derived from MSCs originally taken from human umbilical cord tissue (HucMDEs derived from HucMSCs), to treat...

Publishing in Aging Cell, researchers have devised a way to delay the aging of the thymus by targeting GPR40, a key receptor in its epithelial cells. The organ that involutes The thymus trains a certain subset of immune cells, which are named T cells due to their relationship with it. As the thymus ages, its...