Josh Conway

Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. Backbreaking labor is exactly that It has been long-held conventional wisdom that a lifetime of heavy physical labor leads to the early development of arthritis. This has been backed up...

In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells' gene expression will respond to interventions. The need for prediction Simulating biological processes on a computer is an incredibly difficult task. While advanced algorithms such as Google's AlphaFold have revolutionized protein folding,...

Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several clinical trials have found that taking omega-3 PUFAs has benefits for older people. One study found that it reduces the rate of aging according to epigenetic clocks [1], while...

Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts are closely related Cataracts, which cloud the lenses of the eye, are one of the most common sources of age-related vision loss [1]. While they are treatable through surgery...

In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced by the senescence-associated secretory phenotype (SASP). Heterogeneity on top of heterogeneity Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...

In Aging Cell, researchers have elucidated the relationship between intestinal aging and age-related changes to the gut microbiome. Two interdependent biologies The human gut works through the interaction of two entirely different sets of cells. The first is the body's actual cells, including the intestinal barrier between the gut and the rest of the body,...