Josh Conway

Researchers have discovered key biomarkers that are strongly linked to all-cause mortality and identified four measurements with independent predictive power. Biological versus chronological This paper opens with a discussion of a familiar fact for people interested in living longer: one's biological age is not the same as one's chronological age [1]. Biological age gives a...

Researchers have created a deep learning-based biomarker, SASP Score, that evaluates the combined effects of the senescence-associated secretory phenotype (SASP) circulating in the bloodstream. Measuring an overall burden Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart's ability to process energy. Mitochondrial transplantation was found to be effective against this increase in a mouse model. The heart needs energy Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and...

Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced skin aging (photoaging) in mice by restoring their cells' ability to get rid of their own damaged mitochondria (mitophagy). Wrinkles are only a small part of the problem Chronic exposure to...

Researchers have established how a protein that is nearly absent in the literature, PTCHD4, is linked to cellular senescence. Very little previous work In most papers, after a customary discussion of the mechanics of cellular senescence and current methods of handling it and its repercussions, the researchers go on to discuss previous work relating to...

A team of researchers has discovered that mitochondrial health and location may be critical to why cognitive plasticity decreases with age. Old mammals and new tricks The adage 'you can't teach an old dog new tricks' is true across a wide variety of organisms; neural plasticity decreases with age in rodents, non-human primates, and people...