Josh Conway

Researchers have established how a protein that is nearly absent in the literature, PTCHD4, is linked to cellular senescence. Very little previous work In most papers, after a customary discussion of the mechanics of cellular senescence and current methods of handling it and its repercussions, the researchers go on to discuss previous work relating to...

A team of researchers has discovered that mitochondrial health and location may be critical to why cognitive plasticity decreases with age. Old mammals and new tricks The adage 'you can't teach an old dog new tricks' is true across a wide variety of organisms; neural plasticity decreases with age in rodents, non-human primates, and people...

Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Calcium is not just for bones Skeletal muscle cells use calcium ions to control how and when they contract. This activity is modulated by CaMKII, a protein kinase that also regulates muscle adaptations in response to...

Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice. Growth but diabetes Growth hormone affects the metabolism of fats (lipids), increasing the levels of circulating fatty acids while increasing insulin-like growth factor 1 (IGF-1) and impairing the function of insulin itself [1]. Growth...

Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. When DNA modifies itself Long interspersed elements-1 (LINE-1) have existed in organisms' genomes, including our own, for well over a billion years [1]. They are the only autonomous elements...

Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has found that, like with many other injuries, tendon injuries have an age-related component. The tendons of the biceps and rotator cuffs are more commonly injured...