Matthew O'Connor

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Pasta
A team of researchers has developed Pasta, a transcriptomic clock that accurately predicts the age-related effects of various compounds and gene expressions. Epigenetics versus transcriptomics What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different...
Ships together
The cost of the broken sickcare system Modern medicine is effectively based on a reactive management approach. It typically waits for an acute organ failure, such as a heart attack, and then it deploys high-cost, non-curative interventions to manage the fallout. This is a flawed and extremely costly approach for both the patient and healthcare...
No Valine Mouse
A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue. Protein composition matters The debates around how much protein people should consume to maximize their healthspan and...
The fight for longevity treatments that measurably improve and lengthen quality of life is ongoing in research, treatment, and policy, with promising successes and a horrifying failure. Here's what's happened in July. Interviews Gabriel Cian on Building the 2060 Longevity Ecosystem: In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem...
Jose Pedro Castro Interview
For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its crucial role in aging and disease. Earlier this month, he received the Rising...
Clock precision
A team of researchers has concluded that while methylation-based epigenetic clocks generally give reliable outputs when given the same inputs, short-term biological fluctuations can drastically change their results. Technical and biological reliability What Are Epigenetic ClocksAn epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to...