Matthew O'Connor

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T cells attacking cancer
Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune system Modern cancer immunotherapies only work for a minority of patients. The reason, broadly, is that many tumors are immunologically “cold”: they do not trigger, and/or actively suppress, the...
Matthew O'Connor
Most cardiovascular trials focus on lowering LDL cholesterol or reducing inflammation to slow disease progression. UDP-003 targets the root cause: toxic 7-ketocholesterol (7KC) inside macrophages and soft plaques. It is designed to convert bloated foam cells back into healthy macrophages that can actively clear the hard plaque. This clinical trial took place at CMAX, a...
Cyclarity
Cyclarity Therapeutics, Inc., a clinical stage biopharmaceutical company engineering cyclodextrin molecules into simple, scalable, and affordable therapies that bind and remove toxic targets to address root causes of age-related disease, has just unveiled data from a clinical trial of its lead candidate, UDP-003, at the American Heart Association Vascular Discovery Scientific Sessions. Data from a study...
This month, a group of researchers published an annual report on the clinical trials that are testing drugs for Alzheimer’s disease. Overall, they reported an increase in the number of trials, with 158 drugs investigated across 192 trials [1]. A growing problem The projections regarding the prevalence of Alzheimer’s disease are merciless. While in 2017,...
AI for Practical Longevity
We are super excited to share with you that today we released AI4L - "AI for Practical Longevity", an open-source system that enables anyone to produce rigorous, evidence-based reviews of health and longevity interventions using frontier AI models. Our novel "Audit-Driven Prompting" method enables iterative self-auditing and eliminates hallucinations with live citation verification and zero-tolerance...
Muscle and fat
A new study suggests that GLP-1 receptor agonists do not affect muscle mass any more than weight loss caused by caloric restriction, and this appears to be true for strength as well [1]. What do we lose when we lose weight? GLP-1-based drugs, such as semaglutide and tirzepatide, have transformed obesity treatment. People on these...