Matthew O'Connor

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Aggressive cancer
A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Some blocking techniques are temporary Many cancers depend heavily on a particular oncogenic signal to maintain their growth. Drugs that block these drivers can, therefore, produce dramatic tumor shrinkage. A major clinical problem, however,...
Bicycle racers
A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. long and moderate Exercise is a well-known lifestyle factor that can positively impact health. Exercise benefits multiple cells,...
Rat tendons
Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has found that, like with many other injuries, tendon injuries have an age-related component. The tendons of the biceps and rotator cuffs are more commonly injured...
Microglia attacking a neuron
A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. The living dead Amyotrophic lateral sclerosis (ALS), an age-related neurodegenerative disease, is characterized by the progressive loss of motor neurons. Historically, much of ALS...
Fat cells
Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too much of a regulator leads to dysregulation Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles...
This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to successive perturbations, potentially transforming biological research. Living in a simulation Simulating a living organism on a computer (in silico) has been a dream of both...