July 07, 2026
Scientists have linked disrupted Ca²⁺ homeostasis to aging in both progeroid and naturally aging mice. Rescuing it with a well-known antidepressant significantly increased the animals’ median and maximum lifespan [1]. Calcium ions in progeria and natural aging Cells use calcium ions (Ca²⁺) for signaling, and a rise or fall in cytoplasmic Ca²⁺ switches many pathways...
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where it doesn't belong Calcification is not the same as 'hardening' of blood vessel walls (atherosclerosis), which occurs due to plaque deposits. Calcification occurs when phosphates...
August 03, 2023
Scientists have reported in Nature Aging that impaired mitochondrial uptake of calcium ions leads to changes in inflammatory responses that resemble what happens in aging [1]. Inflammation and aging Inflammation is an essential, evolutionarily conserved process and a fundamental part of the immune response, providing immediate defense against infections by pathogens such as bacteria, viruses,...