Tag: mTORC1

A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue. Protein composition matters The debates around how much protein people should consume to maximize their healthspan and...

In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering mTOR signaling. Senescent cells don't sense nutrients properly Deregulated Nutrient SensingThe four pathways of nutrient-sensing regulate metabolism and influence aging. The four associated key protein groups are IGF-1, mTOR, sirtuins, and AMPK. We call these proteins “nutrient-sensing”...

According to a new study, rapamycin probably interferes with exercise, blunting its effects in older human subjects. This result, however, might be specific to the particular protocol. Can they work together? Physical activity is one of the most potent pro-longevity interventions currently available [2]. Rapamycin is the undisputed champion of small molecules for extending lifespan...

A new study from the Universities of Oxford and Nottingham has uncovered a potential new mechanism by which rapamycin counters immunosenescence. Rather than increasing autophagy or reducing protein synthesis, the effect appears to involve directly reducing DNA damage burden in immune cells [1]. How can this work? Rapamycin, a powerful inhibitor of the nutrient-sensing mTOR...

A team of scientists has reviewed the clinical data regarding low-dose rapamycin therapy in healthy adults. They concluded that, while there is plenty of preclinical data regarding the impact of rapamycin, there is no sufficient evidence that low-dose rapamycin use can extend healthspan and lifespan in healthy humans [1]. An old friend Rapamycin is a...

In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by lifespan.io. Crowdfunded research bears fruit Rapamycin: Benefits, Side Effects, and ResearchRapamycin is a macrolide, a class of antibiotic and it exhibits potent antitumor...