Category: Biology of Aging
Remembering Where We Are in Alzheimer’s Research
October 22, 2023
A pair of neurologists have published a review in Cell discussing the current state of Alzheimer’s therapies, including drugs in early development, treatments in clinical trials, and therapies that are
DNA Damage And Aging Of The Blood Vessels
October 19, 2023
In a paper published in Aging, researchers have explored the relationship between DNA damage and aging of the blood vessels. How arteries age This paper begins with some well-known facts
Treating Hypertension May Reduce Dementia Risk
October 18, 2023
Research published in JAMA Geriatrics analyzed the link between blood pressure, hypertension, and the risk of dementia [1]. Inconsistent research Published research is inconsistent regarding the link between hypertension and
The Longevity World Meets in Dublin for a Second Time
October 17, 2023
Last year’s inaugural Longevity Summit Dublin conference was a good start. Its second iteration, held in August this year, was universally acclaimed for being even bigger and better. Just like
Spermidine May Improve Egg Health and Fertility
October 16, 2023
Reporters publishing in Nature Aging have identified a metabolite that appears to restore the age-related loss of quality of egg cells (oocytes) in mice. Spermidine is not just for sperm
Study Suggests a New Mechanism of Cellular Senescence
October 13, 2023
Scientists have found that leakage of mitochondrial DNA in senescent cells is a major cause of their pro-inflammatory activity, and it can be targeted without clearing those cells out [1].
Why Long-Lived Animals Are Needed for Life Extension Studies
October 12, 2023
A team of researchers, including Matt Kaeberlein and Brian Kennedy, has published a preprint discussing the necessity of using long-lived animals in life extension research. The Interventions Testing Program (ITP)
SIRT2 Works Against Cardiac Aging in Mice and Monkeys
October 10, 2023
Working with non-human primates, scientists have discovered that the protein SIRT2, a member of the sirtuin family, might play an important role in slowing cardiac aging [1]. The heart of
A Mutation Rejuvenates Memory in Worms and Mice
October 9, 2023
A study published in Cell Reports has shown how the activation of a common protein in neurons improves memory in both worms and mammals. Common between animals This paper begins
Improving Quality and Length of Life with Stem Cells
October 5, 2023
A review article published in Stem Cell Research & Therapy has described the ways in which mesenchymal stromal cells (MSCs) are being developed to treat diseases, including age-related diseases. A
Nobel Prize in Medicine Goes to Two mRNA Vaccine Researchers
October 3, 2023
Katalin Karikó and Drew Weissman received this year’s Nobel Prize in Physiology or Medicine for a groundbreaking discovery that facilitated the development of mRNA vaccines and can be relevant to
NMN Reduces Systolic Blood Pressure in Clinical Trial
October 2, 2023
Combining human clinical trial research, cellular analysis, and mouse studies, researchers publishing in the Nature journal Signal Transduction and Targeted Therapy have discovered a relationship between NAD+, hypertension, and the
Study: Waist-to-Hip Ratio Predicts Mortality Better Than BMI
September 29, 2023
A new study suggests that waist-to-hip ratio (WHR) has a more linear correlation with all-cause mortality than either body mass index (BMI) or fat mass index (FMI) and might replace
Restoring Heart Regeneration With a Metabolic Switch
September 28, 2023
In a recent article in Nature, researchers have restored cardiac regeneration to adult mice by disabling fatty acid oxidation, discovering a potential pathway for human treatments. A question of metabolism
Human Clinical Trials of NMN for Safety and Effectiveness
September 27, 2023
In a recent paper, researchers reviewed the literature for human clinical trials that address NMN’s safety and anti-aging effects [1]. The roles of NAD+ and NMN in aging NAD+ (nicotinamide
Remembering Where We Are in Alzheimer’s Research
October 22, 2023
A pair of neurologists have published a review in Cell discussing the current state of Alzheimer’s therapies, including drugs in early development, treatments in clinical trials, and therapies that are prescribed today. The -mab drugs Monoclonal antibodies, drugs whose names end in -mab, have become the
DNA Damage And Aging Of The Blood Vessels
October 19, 2023
In a paper published in Aging, researchers have explored the relationship between DNA damage and aging of the blood vessels. How arteries age This paper begins with some well-known facts about aging and cardiovascular risk. Cardiovascular disease is the single most common cause of death in
Treating Hypertension May Reduce Dementia Risk
October 18, 2023
Research published in JAMA Geriatrics analyzed the link between blood pressure, hypertension, and the risk of dementia [1]. Inconsistent research Published research is inconsistent regarding the link between hypertension and dementia. Some studies suggest an association between midlife hypertension and increased dementia risk. Other studies have
The Longevity World Meets in Dublin for a Second Time
October 17, 2023
Last year’s inaugural Longevity Summit Dublin conference was a good start. Its second iteration, held in August this year, was universally acclaimed for being even bigger and better. Just like the last time, this conference was marked by a considerable presence of longevity advocates alongside scientists
Spermidine May Improve Egg Health and Fertility
October 16, 2023
Reporters publishing in Nature Aging have identified a metabolite that appears to restore the age-related loss of quality of egg cells (oocytes) in mice. Spermidine is not just for sperm While it was originally found in semen, the metabolite spermidine has been found in many different
Study Suggests a New Mechanism of Cellular Senescence
October 13, 2023
Scientists have found that leakage of mitochondrial DNA in senescent cells is a major cause of their pro-inflammatory activity, and it can be targeted without clearing those cells out [1]. A new aspect of senescence Clearing senescent cells with drugs called senolytics is one of the
Why Long-Lived Animals Are Needed for Life Extension Studies
October 12, 2023
A team of researchers, including Matt Kaeberlein and Brian Kennedy, has published a preprint discussing the necessity of using long-lived animals in life extension research. The Interventions Testing Program (ITP) uncovers weaknesses The ITP is run by the National Institutes of Aging and described by these
SIRT2 Works Against Cardiac Aging in Mice and Monkeys
October 10, 2023
Working with non-human primates, scientists have discovered that the protein SIRT2, a member of the sirtuin family, might play an important role in slowing cardiac aging [1]. The heart of the matter The heart is arguably the hardest worker among the organs, constantly pumping enormous amounts
A Mutation Rejuvenates Memory in Worms and Mice
October 9, 2023
A study published in Cell Reports has shown how the activation of a common protein in neurons improves memory in both worms and mammals. Common between animals This paper begins with a striking fact: C.elegans worms, mice, and people all lose memory with age [1] and
Improving Quality and Length of Life with Stem Cells
October 5, 2023
A review article published in Stem Cell Research & Therapy has described the ways in which mesenchymal stromal cells (MSCs) are being developed to treat diseases, including age-related diseases. A lack of clinical treatments The reviewers begin their paper by discussing the most common age-related diseases.
Nobel Prize in Medicine Goes to Two mRNA Vaccine Researchers
October 3, 2023
Katalin Karikó and Drew Weissman received this year’s Nobel Prize in Physiology or Medicine for a groundbreaking discovery that facilitated the development of mRNA vaccines and can be relevant to future anti-aging therapies. A crucial discovery The COVID-19 pandemic was one of the biggest health challenges
NMN Reduces Systolic Blood Pressure in Clinical Trial
October 2, 2023
Combining human clinical trial research, cellular analysis, and mouse studies, researchers publishing in the Nature journal Signal Transduction and Targeted Therapy have discovered a relationship between NAD+, hypertension, and the immune signal CD38. A vital component in metabolic function This research begins with a discussion of
Study: Waist-to-Hip Ratio Predicts Mortality Better Than BMI
September 29, 2023
A new study suggests that waist-to-hip ratio (WHR) has a more linear correlation with all-cause mortality than either body mass index (BMI) or fat mass index (FMI) and might replace BMI as a metric of choice [1]. Is BMI good enough? Comparing total mass to height,
Restoring Heart Regeneration With a Metabolic Switch
September 28, 2023
In a recent article in Nature, researchers have restored cardiac regeneration to adult mice by disabling fatty acid oxidation, discovering a potential pathway for human treatments. A question of metabolism As heart muscle cells (myocytes) mature, they make a metabolic switch from glycolysis to the oxidation
Human Clinical Trials of NMN for Safety and Effectiveness
September 27, 2023
In a recent paper, researchers reviewed the literature for human clinical trials that address NMN’s safety and anti-aging effects [1]. The roles of NAD+ and NMN in aging NAD+ (nicotinamide adenine dinucleotide) is a molecule essential in such processes as metabolism, cell death, aging, DNA repair,