Category: Research
Gene Therapy to Delay Reproductive Senescence
November 7, 2022
A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through
Protecting Memory Through Gut Bacteria
November 3, 2022
Researchers publishing in Nutrients have shown that adding a strain of lactic acid bacteria to the gut flora of older, memory-impaired people partially alleviates their memory problems. A specific anti-inflammatory
Klotho Reduces Arterial Calcification Through Autophagy
November 2, 2022
In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition
Cellular Reprogramming Extends Lifespan, Healthspan in Mice
November 1, 2022
Scientists have shown that continuous low-dose induction of reprogramming factors and a single early life reprogramming treatment both significantly increase lifespan and healthspan in progeroid mice while altering their
Vitamin D Combats Oxidative Stress in Gingival Cells
October 31, 2022
A cellular study published in the Journal of Dental Sciences has shown that Vitamin D alleviates inflammaging related to the oxidative stress brought on by advanced glycation end-products (AGEs). Diabetes
Turn.bio Announces Preliminary Results of a CAR-T Cell Study
October 28, 2022
Turn.bio has announced that its proprietary cellular reprogramming technology was able to significantly increase the proliferative and cytotoxic potential of premanufactured CAR-T cells in vitro. Turn.bio, a developer of mRNA-based
New Compounds Beat Resveratrol in Sirtuin Activation
October 27, 2022
A recent study published in Molecules has tested multiple thiazole-based derivatives that appear to activate the sirtuin SIRT1 more than resveratrol [1]. Sirtuins Resveratrol, commonly found in grape skins and
Pain Is Associated with Increased Risk of Falls in Adults
October 26, 2022
In a new longitudinal study published in European Geriatric Medicine, the researchers have shown that people experiencing moderate to severe pain in multiple sites have an increased risk of falls,
HIIT and Intermittent Fasting Show Cumulative Effect
October 21, 2022
Scientists have shown that both high-intensity interval training (HIIT) and time-restricted eating improve metabolism in healthy overweight women, with their combination providing the biggest effect [1]. Which one is better?
Bowhead Whale’s Longevity May Be Due to Twin Genes
October 20, 2022
A preprint published in bioRxiv has partially explained the lifespan of the bowhead whale through its duplication of CDKN2C, which regulates how cells divide. Peto’s paradox It would be logical
Senescent Cells Can Be Good or Bad According to New Study
October 19, 2022
New research has scientists reconsidering the role of ‘zombie’ cells that drive some aspects of aging and whether they should be eliminated using senolytic drugs. It turns out that not
Air Pollution Impairs Lung Function
October 19, 2022
In a new study published in Ecotoxicology and Environmental Safety, the researchers have shown that air pollution leads to lung function decline accompanied by lung and intestinal microbiome disbalances [1].
The Impact of Genetic Risk Factors on Healthspan
October 18, 2022
A research paper published in Nature Medicine has shown the results of a broad investigation into gene variants associated with healthspan [1]. Genome-wide association studies A genome-wide association study is
T Cells Acquire Telomeres from Antigen-Presenting Cells
October 18, 2022
Scientists have found that when T cells are activated by antigen-presenting cells, the activating cells donate chunks of their telomeres to the T cells, preventing senescence [1]. Imperfect protection Telomeres
Older Immune Cells Kill Cancer Cells More Quickly
October 13, 2022
In Aging Cell, researchers have published the surprising and counterintuitive finding that older immune cells are able to kill cancer cells more quickly than their younger counterparts. The aging of
Gene Therapy to Delay Reproductive Senescence
November 7, 2022
A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through gene therapy. A well-studied approach IGF-1 is a well-known anti-inflammatory compound, having shown positive effects in
Protecting Memory Through Gut Bacteria
November 3, 2022
Researchers publishing in Nutrients have shown that adding a strain of lactic acid bacteria to the gut flora of older, memory-impaired people partially alleviates their memory problems. A specific anti-inflammatory bacterium The researchers begin their paper by noting that mild cognitive impairment (MCI) is associated with
Klotho Reduces Arterial Calcification Through Autophagy
November 2, 2022
In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition of minerals in the cardiovascular system, is a complex pathological process that accompanies aging. It is
Cellular Reprogramming Extends Lifespan, Healthspan in Mice
November 1, 2022
Scientists have shown that continuous low-dose induction of reprogramming factors and a single early life reprogramming treatment both significantly increase lifespan and healthspan in progeroid mice while altering their epigenetic landscape [1]. In vivo reprogramming Cellular reprogramming is the process of treating cells with compounds
Vitamin D Combats Oxidative Stress in Gingival Cells
October 31, 2022
A cellular study published in the Journal of Dental Sciences has shown that Vitamin D alleviates inflammaging related to the oxidative stress brought on by advanced glycation end-products (AGEs). Diabetes and AGEs Previous research has shown that the uncontrolled blood sugars associated with Type 2 diabetes
Turn.bio Announces Preliminary Results of a CAR-T Cell Study
October 28, 2022
Turn.bio has announced that its proprietary cellular reprogramming technology was able to significantly increase the proliferative and cytotoxic potential of premanufactured CAR-T cells in vitro. Turn.bio, a developer of mRNA-based cellular reprogramming technologies, has announced preliminary results from its current trial. The announcement was made by
New Compounds Beat Resveratrol in Sirtuin Activation
October 27, 2022
A recent study published in Molecules has tested multiple thiazole-based derivatives that appear to activate the sirtuin SIRT1 more than resveratrol [1]. Sirtuins Resveratrol, commonly found in grape skins and red wine, generated some of the initial interest in sirtuin activators after initial studies showing many
Pain Is Associated with Increased Risk of Falls in Adults
October 26, 2022
In a new longitudinal study published in European Geriatric Medicine, the researchers have shown that people experiencing moderate to severe pain in multiple sites have an increased risk of falls, particularly in middle age [1]. Aging and falls In one’s youth, falling doesn’t seem dangerous and
HIIT and Intermittent Fasting Show Cumulative Effect
October 21, 2022
Scientists have shown that both high-intensity interval training (HIIT) and time-restricted eating improve metabolism in healthy overweight women, with their combination providing the biggest effect [1]. Which one is better? Good dietary habits and physical activity are currently our best options for living longer and healthier
Bowhead Whale’s Longevity May Be Due to Twin Genes
October 20, 2022
A preprint published in bioRxiv has partially explained the lifespan of the bowhead whale through its duplication of CDKN2C, which regulates how cells divide. Peto’s paradox It would be logical for longer-lived animals to be more susceptible to cancer than shorter-lived animals over time, as they
Senescent Cells Can Be Good or Bad According to New Study
October 19, 2022
New research has scientists reconsidering the role of ‘zombie’ cells that drive some aspects of aging and whether they should be eliminated using senolytic drugs. It turns out that not all senescent cells are necessarily bad and that some may be helpful. Introducing zombie cells As
Air Pollution Impairs Lung Function
October 19, 2022
In a new study published in Ecotoxicology and Environmental Safety, the researchers have shown that air pollution leads to lung function decline accompanied by lung and intestinal microbiome disbalances [1]. Air quality and longevity It is widely accepted that both intrinsic and extrinsic factors influence lifespan.
The Impact of Genetic Risk Factors on Healthspan
October 18, 2022
A research paper published in Nature Medicine has shown the results of a broad investigation into gene variants associated with healthspan [1]. Genome-wide association studies A genome-wide association study is an effort to use enormous databases and computational analysis to examine the genetic causes of disease
T Cells Acquire Telomeres from Antigen-Presenting Cells
October 18, 2022
Scientists have found that when T cells are activated by antigen-presenting cells, the activating cells donate chunks of their telomeres to the T cells, preventing senescence [1]. Imperfect protection Telomeres are sequences of TTAGGG repeats at the ends of our chromosomes that protect their integrity. Because
Older Immune Cells Kill Cancer Cells More Quickly
October 13, 2022
In Aging Cell, researchers have published the surprising and counterintuitive finding that older immune cells are able to kill cancer cells more quickly than their younger counterparts. The aging of CD8+ T cells The researchers introduce their subject by discussing CD8+ T cells in the context