Category: Artificial Intelligence
Young Brain Cells Outcompete Old Cells in a Mouse Model
July 28, 2023
In a mouse model of Huntington’s disease, scientists showed that injected young healthy brain cells can outcompete and eventually replace old, diseased ones. The results might be relevant for other
Neil Riordan on the Rising Tide of Stem Cell Therapies
July 27, 2023
“Stem Cell Therapy: A Rising Tide” by Neil Riordan is a comprehensive exploration of stem cell therapy along with its potential benefits, limitations, and prospects. The father of mesenchymal stem
Psychedelic Drugs for Alzheimer’s Treatment
July 27, 2023
A review article published in European Neuropsychopharmacology has described how and why psychedelic compounds may be useful in treating neurodegenerative diseases such as Alzheimer’s. A question of neuroplasticity Neuroplasticity refers
Some Age-Related Gene Expression Changes May Extend Life
July 26, 2023
In a recent paper published in Nucleic Acids Research, researchers analyzed the organs of several mammalian species, exploring gene expression patterns associated with maximum lifespan and finding surprising correlations [1].
Review Links Statins to Insulin Resistance and Diabetes
July 25, 2023
A new systematic review lends support to the idea that statins, which are life-saving cholesterol-lowering drugs, are associated with an increased risk of insulin resistance and type 2 diabetes [1].
Metformin Protects Against Muscle Atrophy in Clinical Trial
July 24, 2023
Researchers publishing in Aging Cell have documented a human clinical trial showing that metformin reduces atrophy caused by long periods of bed rest. A common problem and a well-known diabetes
New System-Specific Epigenetic Clocks Revealed
July 21, 2023
A group of researchers led by Morgan Levine of Altos Labs has created a set of methylation clocks that can detect various aging patterns [1]. The less-than-perfect revolution The discovery
Repairing the Long-Term Damage of Smoking
July 20, 2023
Researchers publishing in Aging Cell have described how treating the increased senescent cell burden that comes with cigarette smoke exposure can repair some of the damage. Senescent cells and COPD
Finding The Genes for Longevity in Mammals
July 19, 2023
Researchers have analyzed the activity of genes in the livers, kidneys, and brains of over a hundred mammals and found genes that are consistently associated with longevity [1]. The search
Rejuvenating Cells Using A New Small Molecule Approach
July 18, 2023
A team led by renowned Harvard geroscientists David Sinclair and Vadim Gladyshev has reported successful chemically induced partial cellular reprogramming in vitro. The researchers have also developed a novel cellular
Making Genetically Engineered Stem Cells Viable
July 17, 2023
Researchers publishing in Cell Stem Cell have announced a new method of accurately and rapidly cloning genetically engineered stem cells. CRISPR is still imperfect While the accuracy of genetic modification
Senolytics Restore Regeneration in Killifish
July 13, 2023
Researchers publishing in npj regenerative medicine have found that destroying senescent cells through a well-known senolytic combination gives older killifish back some of their regenerative abilities. Regeneration, for a while
Editing Mitochondrial DNA
July 12, 2023
The Journal Club returns on 25th July at 12:00 Eastern time to the lifespan.io Facebook channel. Editing mitochondrial DNA (mtDNA) has long been a challenge and systems such as CRISPR,
Using Proteins and RNA to Determine How Old You Are
July 10, 2023
A paper published in Aging goes into detail about the proteins and RNA pieces that increase and decrease with aging, suggesting a multiple-clock approach to biomarkers. Blood proteins change with
The Longevity Factor Klotho Improves Memory in Monkeys
July 9, 2023
Researchers have explained in Nature Aging how klotho, a factor associated with longevity, improves the cognitive abilities of rhesus macaques. Moving on from mice This paper begins with a discussion
Young Brain Cells Outcompete Old Cells in a Mouse Model
July 28, 2023
In a mouse model of Huntington’s disease, scientists showed that injected young healthy brain cells can outcompete and eventually replace old, diseased ones. The results might be relevant for other neurodegenerative diseases [1]. When neurons’ helpers fail The non-neuronal cells in the brain are collectively known
Neil Riordan on the Rising Tide of Stem Cell Therapies
July 27, 2023
“Stem Cell Therapy: A Rising Tide” by Neil Riordan is a comprehensive exploration of stem cell therapy along with its potential benefits, limitations, and prospects. The father of mesenchymal stem cell research, Arnold Caplan, dubbed Riordan as a pioneering figure in stem cell research and application.
Psychedelic Drugs for Alzheimer’s Treatment
July 27, 2023
A review article published in European Neuropsychopharmacology has described how and why psychedelic compounds may be useful in treating neurodegenerative diseases such as Alzheimer’s. A question of neuroplasticity Neuroplasticity refers to the ability of neurons to remodel themselves, forming new connections in response to stimuli. Many
Some Age-Related Gene Expression Changes May Extend Life
July 26, 2023
In a recent paper published in Nucleic Acids Research, researchers analyzed the organs of several mammalian species, exploring gene expression patterns associated with maximum lifespan and finding surprising correlations [1]. How and why gene expression changes As organisms age, their gene activity patterns change. To understand
Review Links Statins to Insulin Resistance and Diabetes
July 25, 2023
A new systematic review lends support to the idea that statins, which are life-saving cholesterol-lowering drugs, are associated with an increased risk of insulin resistance and type 2 diabetes [1]. Statins’ dark side Statins, drugs that improve the lipid profile by reducing harmful LDL cholesterol, are
Metformin Protects Against Muscle Atrophy in Clinical Trial
July 24, 2023
Researchers publishing in Aging Cell have documented a human clinical trial showing that metformin reduces atrophy caused by long periods of bed rest. A common problem and a well-known diabetes drug Long periods of disuse cause muscles to atrophy and accelerate the age-related muscle wasting known
New System-Specific Epigenetic Clocks Revealed
July 21, 2023
A group of researchers led by Morgan Levine of Altos Labs has created a set of methylation clocks that can detect various aging patterns [1]. The less-than-perfect revolution The discovery that genome methylation patterns correlate with various processes of aging led to the development of methylation
Repairing the Long-Term Damage of Smoking
July 20, 2023
Researchers publishing in Aging Cell have described how treating the increased senescent cell burden that comes with cigarette smoke exposure can repair some of the damage. Senescent cells and COPD Chronic obstructive pulmonary disorder (COPD) and idiopathic pulmonary fibrosis (IPF), both of which are well-known consequences
Finding The Genes for Longevity in Mammals
July 19, 2023
Researchers have analyzed the activity of genes in the livers, kidneys, and brains of over a hundred mammals and found genes that are consistently associated with longevity [1]. The search for longevity-associated genes Between the shortest-living and the longest-living mammal, there is a more than 100-fold
Rejuvenating Cells Using A New Small Molecule Approach
July 18, 2023
A team led by renowned Harvard geroscientists David Sinclair and Vadim Gladyshev has reported successful chemically induced partial cellular reprogramming in vitro. The researchers have also developed a novel cellular rejuvenation assay [1]. Smaller than proteins Complete cellular reprogramming using the Yamanaka factors was first accomplished
Making Genetically Engineered Stem Cells Viable
July 17, 2023
Researchers publishing in Cell Stem Cell have announced a new method of accurately and rapidly cloning genetically engineered stem cells. CRISPR is still imperfect While the accuracy of genetic modification through the well-known CRISPR/Cas9 system continues to improve, the technology remains imperfect. Small mistakes were initially
Senolytics Restore Regeneration in Killifish
July 13, 2023
Researchers publishing in npj regenerative medicine have found that destroying senescent cells through a well-known senolytic combination gives older killifish back some of their regenerative abilities. Regeneration, for a while Killifish, like starfish and salamanders, are some of the most well-known regenerators of the animal kingdom,
Editing Mitochondrial DNA
July 12, 2023
The Journal Club returns on 25th July at 12:00 Eastern time to the lifespan.io Facebook channel. Editing mitochondrial DNA (mtDNA) has long been a challenge and systems such as CRISPR, which make editing regular DNA faster and easier, are very difficult to use when it comes
Using Proteins and RNA to Determine How Old You Are
July 10, 2023
A paper published in Aging goes into detail about the proteins and RNA pieces that increase and decrease with aging, suggesting a multiple-clock approach to biomarkers. Blood proteins change with age The researchers start out by discussing existing clocks based on such measurements as imaging [1]
The Longevity Factor Klotho Improves Memory in Monkeys
July 9, 2023
Researchers have explained in Nature Aging how klotho, a factor associated with longevity, improves the cognitive abilities of rhesus macaques. Moving on from mice This paper begins with a discussion of klotho and how it relates to aging. In mice, klotho has been found to improve