Category: Biology of Aging
One Drug to Fight Both Sarcopenia and Osteoporosis
September 21, 2022
In a new study published in Bone Research, Japanese researchers established a novel drug screening system and identified a promising compound to treat age-associated muscle and bone frailty [1]. Musculoskeletal
Early-Onset Cancer Cases Are Rising
September 20, 2022
In a review paper published in Nature, scientists discuss the problem of the rising burden of early-onset cancer [1]. Not just a disease of aging We tend to think of
Inflammation Linked To Alzheimer’s and Parkinson’s
September 19, 2022
In the Journal of Inflammation, researchers from Johns Hopkins University have published a detailed review of the relationship between brain inflammation and the principal diseases of dementia. A focus on
Stem Cell Activity Regulated By Mitochondrial Protein
September 15, 2022
Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells
Removing Senescent Cells to Alleviate Muscular Dystrophy
September 14, 2022
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with
Neuromodulation Improves Memory in Older Adults
September 14, 2022
A new study published in Nature Neuroscience has shown that neuromodulation of low-frequency neuronal activity in the parietal cortex improved working memory, while high-frequency modulation in the prefrontal cortex improved
Injectable Cytokine Factories Eradicate Cancer in Mice
September 13, 2022
Researchers have succeeded in beating a type of cancer previously considered incurable by using microcapsules that contained live cytokine-producing cells [1]. IL-2 is potent but toxic Interleukin-2 (IL-2) therapy was
Lactate Inhibits Tumor Growth in Mice
September 9, 2022
Publishing in Nature, scientists have found that sodium lactate boosts the T cell-mediated anti-cancer immune response, leading to significant inhibition of tumor growth [1]. A double-edged sword As a means
Senescence-Associated Protein Promotes Skin Aging in Mice
September 8, 2022
Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice. The spread of
Brief Rapamycin Treatment in Early Adulthood Combats Aging
September 7, 2022
A study published in Nature Aging has shown that short-term rapamycin treatment in early adulthood extends lifespan in flies and improves gut health in both flies and mice [1]. A
Mitochondrial Division Promotes Muscle Regeneration
September 7, 2022
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This
Umbilical Plasma Injections Reduce Biological Age in Humans
September 6, 2022
Researchers have found that intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people [1]. Old blood, young
Canagliflozin Alleviates Several Aging Pathologies in Mice
September 5, 2022
Scientists have found that canagliflozin, an anti-diabetes drug that is known to extend lifespan in mice, alleviates an array of age-related pathologies, albeit in males only [1]. Anti-diabetes and anti-aging
Two Small Molecules May Provide Partial Reprogramming
September 5, 2022
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This
NAD+ Ameliorates Age-Related Hearing Loss in Mice
August 31, 2022
In a preprint published in bioRxiv, scientists have shown that long-term supplementation of nicotinamide riboside (NR), a NAD+ precursor, alleviates the progression of age-related hearing loss in a mouse model
One Drug to Fight Both Sarcopenia and Osteoporosis
September 21, 2022
In a new study published in Bone Research, Japanese researchers established a novel drug screening system and identified a promising compound to treat age-associated muscle and bone frailty [1]. Musculoskeletal system Muscle health and bone health are tightly interconnected. Various muscular dystrophies are a great example:
Early-Onset Cancer Cases Are Rising
September 20, 2022
In a review paper published in Nature, scientists discuss the problem of the rising burden of early-onset cancer [1]. Not just a disease of aging We tend to think of cancer of a disease of aging, and for a good reason: cancer is indeed highly correlated
Inflammation Linked To Alzheimer’s and Parkinson’s
September 19, 2022
In the Journal of Inflammation, researchers from Johns Hopkins University have published a detailed review of the relationship between brain inflammation and the principal diseases of dementia. A focus on genetics and environment One out of twenty Americans over 85 have Parkinson’s disease [1], and seven
Stem Cell Activity Regulated By Mitochondrial Protein
September 15, 2022
Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis) [1]. Another piece of the puzzle We have recently
Removing Senescent Cells to Alleviate Muscular Dystrophy
September 14, 2022
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with hallmarks of aging Duchenne muscular dystrophy is caused by a mutation that gradually destroys the muscles,
Neuromodulation Improves Memory in Older Adults
September 14, 2022
A new study published in Nature Neuroscience has shown that neuromodulation of low-frequency neuronal activity in the parietal cortex improved working memory, while high-frequency modulation in the prefrontal cortex improved long-term memory in older adults [1]. As people age, their cognitive abilities get worse. This includes
Injectable Cytokine Factories Eradicate Cancer in Mice
September 13, 2022
Researchers have succeeded in beating a type of cancer previously considered incurable by using microcapsules that contained live cytokine-producing cells [1]. IL-2 is potent but toxic Interleukin-2 (IL-2) therapy was the first anti-cancer immunotherapy approved decades ago. It is based on the ability of this inflammatory
Lactate Inhibits Tumor Growth in Mice
September 9, 2022
Publishing in Nature, scientists have found that sodium lactate boosts the T cell-mediated anti-cancer immune response, leading to significant inhibition of tumor growth [1]. A double-edged sword As a means of energy production, the Krebs cycle is preferred by most cells in most conditions. However, there
Senescence-Associated Protein Promotes Skin Aging in Mice
September 8, 2022
Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice. The spread of the SASP The authors of this paper introduce this topic with a familiar discussion of the
Brief Rapamycin Treatment in Early Adulthood Combats Aging
September 7, 2022
A study published in Nature Aging has shown that short-term rapamycin treatment in early adulthood extends lifespan in flies and improves gut health in both flies and mice [1]. A well-studied drug Rapamycin, an inhibitor of mTOR signaling, is capable of extending the lifespan of several
Mitochondrial Division Promotes Muscle Regeneration
September 7, 2022
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This paper begins with a discussion of quiescent muscle stem cells, which are held in reserve until
Umbilical Plasma Injections Reduce Biological Age in Humans
September 6, 2022
Researchers have found that intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people [1]. Old blood, young blood Circulating proteins have a significant impact on our health, and blood plasma transfusion is increasingly
Canagliflozin Alleviates Several Aging Pathologies in Mice
September 5, 2022
Scientists have found that canagliflozin, an anti-diabetes drug that is known to extend lifespan in mice, alleviates an array of age-related pathologies, albeit in males only [1]. Anti-diabetes and anti-aging Canagliflozin, a widely used anti-diabetes drug, belongs to the class of sodium glucose cotransporter 2 (SGLT2)
Two Small Molecules May Provide Partial Reprogramming
September 5, 2022
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells
NAD+ Ameliorates Age-Related Hearing Loss in Mice
August 31, 2022
In a preprint published in bioRxiv, scientists have shown that long-term supplementation of nicotinamide riboside (NR), a NAD+ precursor, alleviates the progression of age-related hearing loss in a mouse model [1]. An overlooked hearing impairment Globally, age-related hearing loss (ARHL) is the most common sensory deficit