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Combining Senolytics and Stem Cells Shows Promise in Mice
A new study associated with Immorta Bio suggests that combining a senolytic vaccine with mesenchymal stem cells might create a synergistic impact. However, the findings rest on acute, artificially induced injury models rather than
An Experimental Proposal for Blocking Ambient Radiation
A perspective published in Aging and Disease has recommended the use of underground laboratory space in order to remove the effects of surface radiation on biological clocks. A question of entropy The cascading failure
Optimizing Guidelines Toward Optimal Health Outcomes
In a recently published perspective paper, the author argues that the UK’s official health guidelines on physical activity and protein intake should be revised to recommend levels necessary to achieve optimal health, rather than
Rescuing Calcium Ion Homeostasis Extends Mouse Lifespan
Scientists have linked disrupted Ca²⁺ homeostasis to aging in both progeroid and naturally aging mice. Rescuing it with a well-known antidepressant significantly increased the animals’ median and maximum lifespan [1]. Calcium ions in progeria
How Muscle Loss and Bone Loss Are Related
Researchers have elucidated some of the links between the age-related loss of muscle (sarcopenia) and the age-related loss of bone (osteoporosis). Related in multiple ways Substantial previous research has described the relationship between muscle
Intermittent Fasting Increases Lifespan in Male Mice
Restricting food access to an 8-hour window increased median lifespan in male mice by 12%. However, that might be due to voluntary caloric restriction induced by the regimen [1]. You are when you eat
Rejuvenation Roundup June 2026
Doing something about aging seems to require action at the most basic genomic level. Here’s what’s been done there and in other areas in June. Interviews The Thalion Initiative: A New Non-Profit With Big
Study Maps Existing Drugs to the Hallmarks of Aging
A new study suggests a way to predict whether existing drugs can extend human lifespan. This method uses a network approach that detects longevity signals in protein interactions [1]. Slowing aging with existing drugs?
How a Primate-Specific RNA Strand Worsens Senescence
Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes senescence worse. The packing matters While non-coding RNA strands (ncRNAs) do not themselves produce proteins, they serve crucial
Cell Type-Specific Aging Predicts Disease Onset
A new study has used aging trajectories of various cell types to predict diseases such as Alzheimer’s and lung cancer [1]. This expands on previous research into organ-specific aging. Age is more than one
Upregulating a Key Cartilage Factor Leads to Osteoarthritis
Researchers have found that sustained expression of excess hypoxia-inducible factor (HIF)-1α leads to unwanted formation of blood vessels (angiogenesis) that destroys cartilage and causes osteoarthritis. A necessary but destructive factor Being required for extracellular
NeuroAge Therapeutics Launches Younger 2027
NeuroAge Therapeutics announced Younger 2027, a six-month biological aging contest in which competitors are measured on a clinical-grade aging panel and retested six months later. Baseline testing kits begin shipping September 1, 2026, with
Glycosylation’s Role in Alzheimer’s Disease
A recent study suggests that hyperglycosylation in brain tissue can be a hallmark of Alzheimer’s disease [1]. Lesser-known Alzheimer’s molecular features Pathological deposits of amyloid-β plaques and tau tangles in the brain are probably
Biological Aging May Be Driving Increased Early-Onset Cancer
A new study links accelerated aging to early-onset solid cancers, while showing that this gap is becoming wider with each new generation [1]. Why do more young people get cancer? While life expectancy has
A Transcriptional Failure Leads to Systemic Inflammation
Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets sticky As part of the transcription process that
Epigenetic Drug Targets Fat, Improving Blood Vessel Health
Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. When vessels can’t “just relax” Cardiometabolic disease (CMD) – characterized, among other things, by
How Antioxidants Can Selectively Remove Some Senescent Cells
In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering mTOR signaling. Senescent cells don’t sense nutrients properly Oxidative stress and mTOR signaling, which determines how
Late-Life Gene Therapy Boosts Lifespan in Mice by 20%
In a new study, muscle-targeted viral-vector-based delivery of the protein FGF21 significantly increased median lifespan in male mice and improved many healthspan markers [1]. Control your energy Metabolic dysregulation is a core cause of
How Senescent Cells Grow the Homes of Cancerous Tumors
A team of reviewers has taken a look at the relationship between cancer, cellular senescence, and vascular overgrowth and published this information in Aging Cell. Different gut cancers form through different pathways The authors
Inducing NREM-Like Neuronal Patterns Mimics Sleep Benefits
Scientists have “faked” sleep in mice by artificially creating the on/off neuronal firing pattern similar to that seen in non-REM sleep. This produced sleep-like effects, including improved learning memory [1]. Can sleep be emulated?
The Immune System Maintains the Microbiome
In a recent paper, researchers have proposed that the immune system and immune surveillance play a central role in maintaining microbial composition throughout life by suppressing microbial proliferation and that aging weakens these processes
How Gut Bacteria Affect Lung Fibrosis
In Aging Cell, researchers have described how a strain of Lactobacillus gut bacteria sends chemical signals that enter the bloodstream and decrease fibrosis in the lungs. The gut-lung axis The gut-brain axis, the term
TimePie Longevity Forum Spotlights Evidence-Based Medicine
As longevity moves from laboratory promise toward clinical validation, China is emerging as one of the largest demand bases shaping the field’s next phase. On September 12–13, 2026, the 7th TimePie Longevity Forum will
Fighting Parkinson’s by Restoring Protein Degradation
Researchers have explained how a protein found in both yeast and humans facilitates the destruction of the core protein responsible for Parkinson’s disease. An aggregate that impairs clearance The loss of proteostasis involves the
Neurons’ Protein Disposal Trick Offers Alzheimer’s Insights
According to a new study, a special protein disposal system, currently found only in neurons, is linked to central hallmarks of Alzheimer’s disease [1]. The membranal proteasome Alzheimer’s disease is defined in part by
Preventing Load-Induced Arthritis at the Cellular Level
Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. Backbreaking labor is exactly that It has been long-held
Forever Healthy Foundation Launches Evipedia.ai
The Forever Healthy Foundation today publicly launched evipedia.ai, an open online encyclopedia of in-depth evidence reviews covering more than 500 health and longevity interventions, including first-generation rejuvenation therapies, supplements, botanicals, lifestyle protocols, and more.
The Thalion Initiative: A New Non-Profit With Big Ambitions
The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With VCs looking for clinical
Rejuvenation Roundup May 2026
Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next few years. Here’s how the field has advanced
Harvard Publishes a Longevity Report for the General Public
The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream. People do want to