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How Inflammaging Is Linked to Epigenetic Aging
A paper in Cell Genomics has described how age-related systemic inflammation (inflammaging) is related to epigenetic aging as measured by four established clocks. Tying
Engineered Stem Cells Become Lifelong Protein Factories
Researchers have genetically engineered blood stem cells to produce B cells that can churn out rare broad-action antibodies to fight HIV, malaria, and flu.
Targeting an Appetite Hormone Receptor for Stronger Muscles
In Aging Cell, researchers have described how suppressing the ghrelin receptor improves muscle function and fights sarcopenia in older mice. An appetite hormone with
Vitamin C Alleviates Aging in Cynomolgus Monkeys
A recent study described a process called ferro-aging, in which iron accumulation leads to oxidative damage and cellular senescence. This process can be delayed
A Single Sauna Session Causes White Blood Cell Mobilization
A new study shows that hitting a sauna for 30 minutes causes a transient spike in the number of circulating white blood cells. The
Why Fast-Cycling Skin Cells Decrease With Age
In Aging Cell, researchers have described how one dermal protein is related to maintaining the populations of fast-cycling skin cells and preserving skin integrity.
APLMS and Kitalys to Host Healthy Longevity in Hong Kong
The Asia-Pacific Longevity Medicine Society (APLMS), in partnership with The Kitalys Institute, announced that the 2026 Asia-Pacific Healthy Longevity International Summit (APAC-LMIS) will be
Affecting a Signaling Pathway Alleviates Alzheimer’s in Mice
A new study shows that the overexpression of somatostatin (SST), a neuropeptide produced in neurons and acting mostly on microglia, lowers inflammation and amyloid
A Combination NAD+ Treatment Has Benefits for Mice
Researchers have found that simultaneously supplying NAD+ through NMN and reducing its loss through apigenin restores muscle function and bone structure to aged mice.
Life Bio’s Trial: Is the FDA Warming to Rejuvenation?
The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials
The Timing of Meals Matters for Biological Aging
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of
APOE4 Increases Neurons’ Excitability Before Symptoms Appear
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by
A Target for Ameliorating Post-Operative Delirium
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a
Insilico and Eli Lilly Announce a Major Collaboration
Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from
How an Enzyme’s Depletion Makes Fat Worse
In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat
Becoming Well-Fed and Sedentary Accelerates Penguin Aging
A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle,
Rejuvenation Roundup March 2026
For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let’s see what’s been done last month to rejuvenate animals and
Modified Immune Cells Target Cancer’s Metabolic Signature
Arming NK and T cells with metabolite-sensing receptors enhances their ability to infiltrate tumors and improves cancer outcomes in mice in a new study
How a Growth Factor and SIRT1 Might Combat Disc Degeneration
Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A
Rubedo Announces Positive Preliminary Results for RLS-1496
Rubedo Life Sciences, Inc. (Rubedo), an AI-driven, clinical-stage biotech focused on discovering and rapidly developing selective cellular rejuvenation medicines targeting aging cells, today announced preliminary
Mitochondria Delivery Method Rescues Parkinson’s in Mice
Scientists used red blood cells as membrane donors to encapsulate healthy mitochondria and send them into diseased cells, achieving improvements across multiple models and
Cellular Senescence and Senotherapeutics: The Expert Roundup
Cellular senescence, a state in which cells stop dividing but resist dying, accumulating in tissues over time, has emerged as one of the most
Two Polyunsaturated Lipids Demonstrate Senolytic Activity
A new study identified two polyunsaturated fatty acids, α-eleostearic acid (α-ESA) and α-ESA methyl ester (α-ESA-me), that showed senolytic activity in cell cultures and
BioAge Labs Provides Business Updates
BioAge Labs, Inc. (“BioAge”, “the Company”), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging,
In Vivo Created CAR T Cells Eliminate Tumors in Mice
In a new study, an ingenious CRISPR-based tool was used to create CAR T cells in vivo instead of the usual in vitro approach.
Buck Institute Launches Healthspan Horizons
The Buck Institute for Research on Aging today announced the launch of Healthspan Horizons, a new initiative designed to address one of the most urgent
Neuroscience of Vitality and Aging Conference in Boston
For the first time, the Neuroscience of Vitality and Aging (NOVA) Conference is bringing together leaders from across neuroscience, biotechnology, policy, and investment to
When Doctors Prescribe Horoscopes: The Trouble With Biological Age Tests
Imagine this pitch: a simple cheek swab or blood spot mailed from home tells you not your birthday but your “true” biological age –
Meat Consumption May Benefit APOE4 Carriers
A new study has found a negative association between unprocessed meat consumption and cognitive decline in carriers of the “pro-Alzheimer’s” APOE ε4 allele. This
Using mRNA to Fight Tau Aggregation in Alzheimer’s
Researchers publishing in Cell Reports Medicine have described the development of a lipid nanoparticle (LNP) that delivers mRNA to neurons in order to stop