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Rejuvenation Roundup May 2026
Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next few years. Here’s how the field has advanced in May. Team
Harvard Publishes a Longevity Report for the General Public
The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age and entering the mainstream. People do want to live longer From
A Better Algorithm for Predicting How Cells Behave
In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells’ gene expression will respond to interventions. The need for prediction Simulating biological processes on
Early Cancer Cells Change Their Surroundings to Form Tumors
Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. This can inform future early-stage cancer therapies [1]. Cancer is a disease of aging. With the exception of
Cardiovascular Health During the Menopausal Transition
A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared with premenopausal women, after adjusting for age [1]. Menopausal health decline
Tau Protein Is Crucial for Encoding Long-Term Memory
Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer’s and related disorders: helping encode long-term memory. This can inform novel approaches that target tau [1]. In sickness
How Omega-3 Fatty Acids May Alleviate Kidney Disease
Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several clinical trials have found that taking omega-3 PUFAs has benefits for
Mitochondrial Aging Linked to Losing Crucial Membrane Lipid
Scientists have found that the levels of phosphatidylcholine, the most abundant lipid in mitochondrial membranes, decline with age, driving mitochondrial aging in worms and possibly humans. Supplementing the lipid helped in an in vitro experiment [1]. What
How an Oxidative Stress Regulator Makes Cataracts Worse
Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts are closely related Cataracts, which cloud the lenses of the eye,
Untangling Cellular Senescence at Its Roots
In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced by the senescence-associated secretory phenotype (SASP). Heterogeneity on top of heterogeneity It is well-known that senescent cells
China Launches Standardized Physician Education in Longevity
Beijing, China — In response to the growing healthcare demands of a rapidly ageing population, China has launched its first national competency-based education programme in longevity medicine, marking a significant step toward integrating healthy longevity and preventive
CRISPR-Based System Targets RNA and Kills Cells on Demand
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted assassination of cells CRISPR-based systems work by cutting or changing DNA
Developing a Drug To Reverse Heart Disease
We have spoken with Reason from Repair Biotechnologies about his company’s lead candidate, REP-0004, a drug targeting the liver to reduce excess intracellular free cholesterol. The FDA has granted Repair Bio an orphan drug indication, and the
New mRNA Therapy Destroys Cancer by Improving T Cell Priming
Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune system Modern cancer immunotherapies only work for a minority of patients.
Matthew O’Connor on Cyclarity’s Successful Phase 1 Trial
Most cardiovascular trials focus on lowering LDL cholesterol or reducing inflammation to slow disease progression. UDP-003 targets the root cause: toxic 7-ketocholesterol (7KC) inside macrophages and soft plaques. It is designed to convert bloated foam cells back
Cyclarity Unveils Oxidized Cholesterol Excretion Data
Cyclarity Therapeutics, Inc., a clinical stage biopharmaceutical company engineering cyclodextrin molecules into simple, scalable, and affordable therapies that bind and remove toxic targets to address root causes of age-related disease, has just unveiled data from a clinical
Current Clinical Trials of Alzheimer’s Drugs
This month, a group of researchers published an annual report on the clinical trials that are testing drugs for Alzheimer’s disease. Overall, they reported an increase in the number of trials, with 158 drugs investigated across 192
Forever Healthy Releases AI4L 1.0 for Practical Longevity
We are super excited to share with you that today we released AI4L – “AI for Practical Longevity”, an open-source system that enables anyone to produce rigorous, evidence-based reviews of health and longevity interventions using frontier AI
GLP-1 Drugs’ Muscle Effects Similar to Ordinary Weight Loss
A new study suggests that GLP-1 receptor agonists do not affect muscle mass any more than weight loss caused by caloric restriction, and this appears to be true for strength as well [1]. What do we lose
Junyue Cao on How the Body Ages, Cell by Cell
Dr. Junyue Cao is a professor at the Rockefeller University, and his lab develops ultra-high-throughput single-cell technologies and applies them to the biology of aging. In a recent paper published in Science, his team used a technique
How Intestinal Aging Encourages Harmful Bacteria
In Aging Cell, researchers have elucidated the relationship between intestinal aging and age-related changes to the gut microbiome. Two interdependent biologies The human gut works through the interaction of two entirely different sets of cells. The first
Creatine Shows Synergy With Exercise in Older Adults
In a new study, the popular supplement creatine seemed to add to some of the beneficial effects of power training [1]. Trying the combination in older people Exercise might be the most potent anti-aging intervention known to
“Thinking” AI Outperforms Human Doctors on Real-Life Data
A new study has pit an advanced large language model against human physicians in tasks involving complex reasoning, treatment recommendations, and messy real-world patient records [1]. Testing a “thinking” model The dream of a ‘computer doctor’ has
The Longevity Investor Network Looks Back at 2025
The Longevity Investor Network (LIN) was created to help bridge the gap between promising longevity startups and the investors capable of helping them scale. Through curated monthly pitch sessions, educational seminars, collaborative diligence, and ecosystem-building events, LIN
Rejuvenation Roundup April 2026
Aging is a multifaceted topic, and it’s becoming more and more clear that the only way to deal with it is piece by piece. Here’s what pieces our industry has put together in April. Advocacy and Analysis
Some Researchers Choose Replacement Over Repair in Aging
A perspective published in Aging Cell details the replacement-based approaches being investigated by several research organizations. Repair versus replacement This perspective begins by noting the inherent difficulty of rejuvenating the human body because of the vast variety
Daytime Napping and Mortality Association in Older Adults
A recent study found an association between longer and more frequent daytime napping and higher mortality risk. The authors suggest using napping frequency and duration as behavioral markers of increased mortality risk [1]. Common activity with a
A Popular Senolytic Treatment Causes Brain Damage in Mice
A new study calls for caution in using the well-known senolytic treatment of dasatinib and quercetin (D+Q), showing that it causes damage in certain regions of the brain, similar to what is observed in multiple sclerosis [1].
Obesity’s Effects on the Immune System May Linger for Years
A new study has suggested that T cells might retain a pro-inflammatory phenotype long after normal weight is regained following a period of obesity. In mice, the effect lasts for weeks, while its existence and duration in
A Robust Senescence Response Helps Wounds Heal
A team of scientists has examined how younger and older mice heal from wounds and found that more robust senescent cell activation in younger animals helps them heal faster. A double-edged sword Multiple experiments have found that