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A Transcriptional Failure Leads to Systemic Inflammation
Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets
Epigenetic Drug Targets Fat, Improving Blood Vessel Health
Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. When vessels can’t “just relax” Cardiometabolic
How Antioxidants Can Selectively Remove Some Senescent Cells
In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering mTOR signaling. Senescent cells don’t sense nutrients properly
Late-Life Gene Therapy Boosts Lifespan in Mice by 20%
In a new study, muscle-targeted viral-vector-based delivery of the protein FGF21 significantly increased median lifespan in male mice and improved many healthspan markers [1]. Control your
How Senescent Cells Grow the Homes of Cancerous Tumors
A team of reviewers has taken a look at the relationship between cancer, cellular senescence, and vascular overgrowth and published this information in Aging Cell. Different
Inducing NREM-Like Neuronal Patterns Mimics Sleep Benefits
Scientists have “faked” sleep in mice by artificially creating the on/off neuronal firing pattern similar to that seen in non-REM sleep. This produced sleep-like effects, including
The Immune System Maintains the Microbiome
In a recent paper, researchers have proposed that the immune system and immune surveillance play a central role in maintaining microbial composition throughout life by suppressing
How Gut Bacteria Affect Lung Fibrosis
In Aging Cell, researchers have described how a strain of Lactobacillus gut bacteria sends chemical signals that enter the bloodstream and decrease fibrosis in the lungs.
TimePie Longevity Forum Spotlights Evidence-Based Medicine
As longevity moves from laboratory promise toward clinical validation, China is emerging as one of the largest demand bases shaping the field’s next phase. On September
Fighting Parkinson’s by Restoring Protein Degradation
Researchers have explained how a protein found in both yeast and humans facilitates the destruction of the core protein responsible for Parkinson’s disease. An aggregate that
Neurons’ Protein Disposal Trick Offers Alzheimer’s Insights
According to a new study, a special protein disposal system, currently found only in neurons, is linked to central hallmarks of Alzheimer’s disease [1]. The membranal
Preventing Load-Induced Arthritis at the Cellular Level
Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. Backbreaking
Forever Healthy Foundation Launches Evipedia.ai
The Forever Healthy Foundation today publicly launched evipedia.ai, an open online encyclopedia of in-depth evidence reviews covering more than 500 health and longevity interventions, including first-generation
The Thalion Initiative: A New Non-Profit With Big Ambitions
The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires
Rejuvenation Roundup May 2026
Approaches that modify the processes of aging at their roots have gone well beyond basic research and into therapies intended for the clinic within the next
Harvard Publishes a Longevity Report for the General Public
The report, titled “Pathways to Longevity”, introduces several important longevity concepts to the general reader and is another sign that the field is coming of age
A Better Algorithm for Predicting How Cells Behave
In a preprint published in arXiv, researchers from Altos Labs have described a machine learning algorithm that performs end-to-end prediction of how cells’ gene expression will
Early Cancer Cells Change Their Surroundings to Form Tumors
Scientists have demonstrated how cancer cells influence neighboring cells to create a favorable niche for the tumor to grow. This can inform future early-stage cancer therapies
Cardiovascular Health During the Menopausal Transition
A recent study compared premenopausal, perimenopausal, and postmenopausal women’s cardiovascular health. Perimenopausal women had about twice the odds of having a poor overall score when compared
Tau Protein Is Crucial for Encoding Long-Term Memory
Scientists have uncovered an unexpected function of the tau protein, which is mostly known for its role in Alzheimer’s and related disorders: helping encode long-term memory.
How Omega-3 Fatty Acids May Alleviate Kidney Disease
Researchers have discovered the role of cellular senescence in the interaction between omega-3 polyunsaturated fatty acids (PUFAs) and chronic kidney disease (CKD). Previous mixed results Several
Mitochondrial Aging Linked to Losing Crucial Membrane Lipid
Scientists have found that the levels of phosphatidylcholine, the most abundant lipid in mitochondrial membranes, decline with age, driving mitochondrial aging in worms and possibly humans.
How an Oxidative Stress Regulator Makes Cataracts Worse
Researchers have outlined a key receptor and protein involved in the formation of cataracts, paving the way for potential treatments targeting them. Oxidative stress and cataracts
Untangling Cellular Senescence at Its Roots
In Aging Cell, researchers have described the differences between primary and secondary senescent cells, comparing radiation-induced senescence to senescence induced by the senescence-associated secretory phenotype (SASP).
China Launches Standardized Physician Education in Longevity
Beijing, China — In response to the growing healthcare demands of a rapidly ageing population, China has launched its first national competency-based education programme in longevity
CRISPR-Based System Targets RNA and Kills Cells on Demand
Scientists have devised a CRISPR-based tool that can kill cells carrying a specific strand of RNA. The tested targets include cancerous and virus-infected cells [1]. Targeted
Developing a Drug To Reverse Heart Disease
We have spoken with Reason from Repair Biotechnologies about his company’s lead candidate, REP-0004, a drug targeting the liver to reduce excess intracellular free cholesterol. The
New mRNA Therapy Destroys Cancer by Improving T Cell Priming
Scientists have found a way to drastically ramp up mouse immune responses to cancer along with flu and COVID-19 [1]. How to wake up the immune
Matthew O’Connor on Cyclarity’s Successful Phase 1 Trial
Most cardiovascular trials focus on lowering LDL cholesterol or reducing inflammation to slow disease progression. UDP-003 targets the root cause: toxic 7-ketocholesterol (7KC) inside macrophages and
Cyclarity Unveils Oxidized Cholesterol Excretion Data
Cyclarity Therapeutics, Inc., a clinical stage biopharmaceutical company engineering cyclodextrin molecules into simple, scalable, and affordable therapies that bind and remove toxic targets to address root